Prevalence and antibiotic resistance profiles of cerebrospinal fluid pathogens in children with acute bacterial meningitis in Yunnan province, China, 2012-2015

Jiang, Hongchao; Su, Min; Kui, Liyue; Huang, Haozhang; Qiu, Lijuan; Li, Li; Ma, Jing; Du, Tingyi; Fan, Mingwu; Sun, Qiangming; Liu, Xiaomei

doi:10.1371/journal.pone.0180161

Cited by 32 publications

(86 citation statements)

References 32 publications

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“…One isolates of H. influenzae b showed lower rate of resistance to ciprofloxacin and ceftriaxone. This is in line with study in china that reported lower rate resistance to ciprofloxacin and ceftriaxone (35).…”

Section: Discussionsupporting

confidence: 92%

“…In the present study the predominant cause of bacterial meningitis among under-five children was S. pneumoniae (34.2%), this is similar with study conducted in China where S. pneumoniae was reported to be the predominant isolate (35). This finding of the present study could be supported by study conducted in Gonder, in Addis Ababa and in Jimma which reported that the predominant isolates was S. pneumoniae 70%, 35.3% and 50% respectively (28,36,37).…”

Section: Discussionsupporting

confidence: 91%

“…Haemophilus influenzae b was isolated in 4 (10.5%) of children with meningitis. This finding is comparable with study conducted in china that reported a prevalence rate of H. influenzae b (9.5%) (35) and…”

Section: Discussionsupporting

confidence: 88%

“…pneumoniae was 68.8% (35). This high rate of penicillin resistance in all reported studies indicates that the need for continued monitoring for penicillin resistance in pneumococcal isolates due to frequent use of the drug.…”

Section: Discussionmentioning

confidence: 72%

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Bacterial isolates from CSF sample and their antimicrobial resistance patters in among under-five children suspected for meningitis in Dilla University Referral Hospital

Awulachew

Diriba

Awoke

2020

Preprint

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Introduction: Bacterial meningitis is medical emergency that requires immediate medical attention. It is a cause of an estimated 288, 649 deaths worldwide per year, of which 94 883 death occur among Under-five children. Up to 24% of the survivors suffer from long-term sequelae such as epilepsy, mental retardation, or sensorineural deafness especially when the disease is contracted during early childhood.Objective: the aim of this study was to assess bacterial isolates of CSF sample and their antimicrobial resistance patterns among under-five children in Dilla University Referral Hospital. Material and Methods:Hospital based cross-sectional study design was used to collect clinical data and CSF sample from under-five children who was suspected for meningitis. Sediment of CSF sample was inoculated to Blood Agar plate, Chocolate Agar plate and Mackonkey Agar for bacterial isolation and identification. Chemical analysis and cytological analysis was also conducted based on standard operating procedures.Results: From a total of 287 CSF sample cultured, causative bacteria were detected in 38 (13.2%). From culture positive cases the most frequent isolate was Streptococcus pneumoniae 13 (34.2%) followed by Staphylococcus aureas 7 (18.4%), Neisseria meningitidis 6 (16%) and Escherichia coli 6 (16%). Haemophilus influenzae b was isolated in 4 (10.5%) of children with meningitis. The other cause of meningitis was Streptococcus agalactiae which accounted (10.5%). Cryptococcus neoformans have been detected in 4 (1.9%) cases of meningitis. Of all bacterial isolates about 42.1% (16/38) bacterial isolates were multidrug resistant. About 38.5% of S. pneumoniae was multidrug resistance while about 33.3% N. meningitis, 50% of H. influenzae, 57.1% of S. aureas and 40% of E. coli showed multidrug resistance Conclusions: High prevalence of bacterial meningitis and high rate of drug resistance were observed. S. pneumoniae was the leading cause of bacterial meningitis among under-five children.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 72%

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Bacterial isolates from CSF sample and their antimicrobial resistance patters in among under-five children suspected for meningitis in Dilla University Referral Hospital

Awulachew

Diriba

Awoke

2020

Preprint

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“…are showed (50.8%) acute bacterial meningitis in pediatric caused GPB infections. 25 Zhu et.al. are found GPB predominant pathogen in pediatric patients caused purulent meningitis were E. coli and Staphylococcus spp.…”

mentioning

confidence: 99%

Microbial Pattern and Antibiotic Susceptibility in Pediatric Intensive Care Unit Dr. Soetomo Hospital, Surabaya

A.A.W.

Irwanto

Dharmawati

et al. 2019

IJTID

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Gram-negative bacterial are known as common pathogen caused infection in Pediatric Intensive Care Unit (PICU). Microbial Pattern and Antibiotic Susceptibility are needed as clinical data for selected appropriate antibiotic therapy. In PICU Dr. Soetomo hospital until now still lacking of Microbial Pattern and Antibiotic Susceptibility data. This descriptive study is to recognized Microbial Pattern and Antibiotic Susceptibility in PICU patients from blood, urine, sputum, stool, cerebrospinal fluid, endotracheal tube, pus swab and pleural fluid culture specimens. Patients whose admitted into PICU without signs of infections were excluded from the study. The inclusion criteria are patients with sign infection as follows: fever < 36,5°C or > 37.5°C, leukocyte < 4000/mm 3 or > 10000/mm 3 , marker infections CRP >10 mg/L or PCT >0,3 ng/mL, bradycardia or tachycardia, tachypnea, infiltrates on chest X-ray, turbid urine, dysuria, thrombophlebitis, abdominal pain or tenderness, and mucous or skin lesion. Medical record data from 2011 to 2016, revealed 1138 patients had positive microbial culture result, wherein positive result came from blood 44.46%, urine 19.15%, sputum 11.59%, stool 8.96%, cerebrospinal fluid 7.50%, endotracheal tube 4.04%, pus swab 2.89%, and pleural fluid 1.41%. The microorganisms found in PICU Dr. Soetomo was dominated with gram negative bacteria. Commonest bacterial that recognized from blood was B. cepacea, urine was E. coli, sputum was P. aeruginosa, Stool was E. coli, Cerebrospinal fluid was S. cohnii, endotracheal tube was K. pneumoniae ESBL, pus swab was S. aureus, and pleural fluid was S. maltophilia. Both gram-negative bacteria and gram-positive bacteria isolates revealed multiple drug resistance to commonly used antibiotic, but still had good susceptibility for antibiotic such as; amikacin, cefoperazone-sulbactam, linezolid, vancomycin and carbapenem group. ABSTRAKBakteri gram negatif merupakan patogen tersering penyebab infeksi di ruang rawat intensif anak. Pola bakteri dan kepekaan antibiotik diperlukan sebagai data klinis dalam pemilihan terapi antibiotik yang sesuai. Di ruang rawat intensif anak RS.Dr. Soetomo hingga saat ini masih sangat kekurangan data mengenai pola bakteri dan kepekaan antibiotik. Penelitian deskriptif ini bertujuan untuk membuat pola bakteri dan kepekaan antibiotika pada pasien yang dirawat di ruang rawat intensif anak dari spesimen darah, urin, sputum, feces, cairan serebrospinal,tabung endotrakeal (ETT), pus luka dan cairan pleura. Pasien yang masuk ke PICU yang tidak menunjukkan tanda dan gejala infeksi di eklusi dari penelitian. Kriteria inklusi pada penelitian ini adalah ditemukannya tanda dan gejala infeksi, antara lain ;demam < 36,5°C or > 37.5°C, kadar leukosit darah < 4000/mm3 or > 10000/mm3, marker infeksi CRP >10 mg/L or PCT >0,3 ng/mL, bradikardi atau takikardi, takipneu, gambaran infiltrate pada radiologi paru,urine yang keruh, nyeri berkemih, tromboplebitis, nyeri perut, dan lesi pada mukosa atau kulit. Dari data rekam medis dari tahun 2011 sampai...

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Characterization and safety evaluation of two beneficial, enterocin-producing Enterococcus faecium strains isolated from kimchi, a Korean fermented cabbage

Valledor

Dioso²,

Bucheli

et al. 2022

Food Microbiology

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Prevalence and antibiotic resistance profiles of cerebrospinal fluid pathogens in children with acute bacterial meningitis in Yunnan province, China, 2012-2015

Cited by 32 publications

References 32 publications

Bacterial isolates from CSF sample and their antimicrobial resistance patters in among under-five children suspected for meningitis in Dilla University Referral Hospital

Bacterial isolates from CSF sample and their antimicrobial resistance patters in among under-five children suspected for meningitis in Dilla University Referral Hospital

Microbial Pattern and Antibiotic Susceptibility in Pediatric Intensive Care Unit Dr. Soetomo Hospital, Surabaya

Characterization and safety evaluation of two beneficial, enterocin-producing Enterococcus faecium strains isolated from kimchi, a Korean fermented cabbage

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