Prevalence and antibiotic susceptibility of ear pathogens isolated from patients in Tripoli, north of Lebanon

Hamzé, Monzer; Osman, Marwan; Mallat, Hassan; Achkar, Marcel

doi:10.3823/801

Cited by 3 publications

(5 citation statements)

References 5 publications

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“…Surprisingly, two studies conducted in Ethiopia and Pakistan showed high level of resistance to ciprofloxacin, with 16.2% and 59% respectively [13,20]. Indeed, our generated data are in accordance with recent national studies reporting an increased level of antimicrobial resistance among infectious bacterial agents, a striking low level of antibiotic awareness among Lebanese population, a spread of counterfeit medicines, and a misuse of antibiotics in Lebanon [6][7][8][9][10][11][26][27][28][29][30][31][32]. Even if this study provides useful information for physicians to develop effective empirical antibiotic treatment for M. catarrhalis infections, we advise to pay attention to this prominent issue and we recommend the implementation of reliable identification and antibiotic susceptibility testing in routine laboratory diagnostics to guide appropriate treatment.…”

Section: Discussionsupporting

confidence: 84%

First data on antimicrobial susceptibility patterns of Moraxella catarrhalis isolates in Lebanon

Hamzé

Osman²,

Mallat³

et al. 2019

int. arab. j antimicrob. agents

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Background. Moraxella catarrhalis is an important bacterial pathogen. Although national data have shown an increase in the levels of antimicrobial resistance in clinical settings in Lebanon, there is a lack of data regarding this human pathogen. This study aimed to determine for the first time the antimicrobial susceptibility profiles of M. catarrhalis isolates in Lebanon. Methods. A total of 34 M. catarrhalis strains were isolated from clinical specimens during the period from November 2010 to March 2019. Bacterial identification was carried out using matrix assisted laser desorption ionization–time of flight mass spectrometry. Antibiotic susceptibility of all isolates was performed according the recommendations of the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Results. A total of 34 non-duplicated M. catarrhalis strains were isolated from nose (n=19), ear (n=7), sputum (n=5), blood (n=1), eye (n=1), and throat (n=1) of patients referred to Nini Hospital in Tripoli, North governorate of Lebanon. Regarding antibiotic susceptibility rates, the percent susceptibility is 100% to the majority of antibiotics, except ampicillin (7.4%), trimethoprim-sulfamethoxazole (85.3%), nalidixic acid (85.3%), and ciprofloxacin (97.1%). Conclusion. To our knowledge, this study is the first investigation regarding the antimicrobial susceptibility patterns of M. catarrhalis isolates in Lebanon. In addition to the high level of resistance to ampicillin, our findings showed the emergence of resistance to trimethoprim-sulfamethoxazole, nalidixic acid and ciprofloxacin. Even if this study provides useful information to develop effective empirical treatment, we recommend the implementation of reliable diagnostic tools to guide appropriate treatment.

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Section: Discussionsupporting

confidence: 84%

First data on antimicrobial susceptibility patterns of Moraxella catarrhalis isolates in Lebanon

Hamzé

Osman²,

Mallat³

et al. 2019

int. arab. j antimicrob. agents

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“…Tetracycline was only active against 15.2% and 26.3% of carbapenem-resistant Enterobacteriaceae and A. baumannii, respectively. This study indicates a very low rate of tigecycline resistance against carbapenem-resistant isolates in Lebanon as it has been observed in previous reports [8,12,14,27].…”

supporting

confidence: 85%

“…The present study shows that quinolones, levofloxacin was the most active among the tested compounds. Levofloxacin and ciprofloxacin resistance rates among Enterobacteriaceae and P. aeruginosa isolates were higher than other tested antibiotic families, but they were within the range of previous Lebanese studies [8,11,12,14]. Surprisingly, no A. baumannii strain was susceptible to fluoroquinolones.…”

supporting

confidence: 53%

“…In Lebanon, as the majority of developing countries, antibiotic resistance remains responsible for significant morbidity and mortality. Numerous epidemiological investigations have reported high levels of antibiotic resistance among Gram-negative bacteria in our country in the last decade [5][6][7][8][9][10][11][12][13][14][15]. Recent studies reported the spread of carbapenemresistant strains in North Lebanon, mainly by OXA-48 production [6,7,[16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology and Antibiotic Susceptibility Patterns of Carbapenem Resistant Gram Negative Bacteria Isolated from Two Tertiary Care Hospitals in North Lebanon

Hamzé

2018

int. arab. j antimicrob. agents

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Background. Antimicrobial resistance is a major public health problem worldwide. Numerous epidemiological studies reported that Lebanon is affected with high levels of antibiotic resistance. The aim of this study is to determine the prevalence and antibiotic susceptibility patterns of carbapenem resistant Gram negative bacteria in North Lebanon during the period 2015-2017. Methods. Carbapenem resistant Gram negative bacteria were isolated from patients referring to Nini hospital and Youssef hospital center. Identification and antibiotic susceptibility testing were performed through conventional tools according to the manufacturer’s recommended procedures and the recommendations of the European Committee on Antimicrobial Susceptibility Testing, respectively. Results. Overall, a total of 290 carbapenem resistant Gram negative bacteria were isolated. Escherichia coli was predominant and represented 39.3% of all isolates, followed by Pseudomonas aeruginosa (24.8%), Acinetobacter baumannii (22.8%), Klebsiella spp. (8.6%), Enterobacter spp. (6.6%), Pantoea spp. (1%), and Proteus vulgaris (0.3%). Our findings showed an alarming increase in the prevalence of carbapenem resistant bacteria every year. On the other hand, colistin, tigecycline, amikacin and fosfomycin remain the most effective agents against carbapenem resistant Gram negative bacteria. Conclusion. This study provided important new laboratory data that could support specialists in infectious diseases in North Lebanon to take the appropriate decision in the treatment of patients at risk for infections with carbapenem resistant Gram negative germs.

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“…Out of five isolated MRSA (13.2%), one isolate is found to be resistant to critically important antibiotics including β -lactams, aminoglycosides, tetracycline and fusidic acid. Although the level of MRSA is lower than that observed in clinical settings [ 21, 22 ], our data reported an alarming increase in the prevalence of MRSA in healthy carriers compared to the burden of MRSA in the last decade [ 8 ]. Our findings are higher than those reported previously among food handlers in developing countries.…”

Section: Full Textmentioning

confidence: 99%

Prevalence of Staphylococcus aureus methicillin-sensitive and methicillin-resistant nasal carriage in food handlers in Lebanon: a potential source of transmission of virulent strains in the community

Osman

Kamal-Dine

Omari

et al. 2019

Access Microbiology

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Purpose To determine the prevalence and virulence determinant genes of nasal colonization by Staphylococcus aureus among food handlers in Tripoli, Lebanon. Methodology Within a cross-sectional study design, nasal swab specimens were collected. Epidemiological and microbiological investigations were performed through conventional culture and MALDI-TOF-MS. Antibiotic susceptibility patterns and genetic virulence determinants including enterotoxin genes were also investigated for all isolates. Results The data herein show that S. aureus nasal carriage is highly prevalent (23.8 %), and that the rate of methicillin-resistant S. aureus (MRSA) carriage was twice as high as in our last report in 2008. Several enterotoxin genes were detected in five isolates including one MRSA and four methicillin-sensitive S. aureus . Conclusion To our knowledge, this is the first investigation in the last decade to examine the carriage prevalence of S. aureus among food handlers in Lebanon. This work reports a concerning level of MRSA, and enterotoxin-producing S. aureus nasal carriage, which could potentially act as a contamination reservoir and lead to food poisoning.

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Prevalence and antibiotic susceptibility of ear pathogens isolated from patients in Tripoli, north of Lebanon

Cited by 3 publications

References 5 publications

First data on antimicrobial susceptibility patterns of Moraxella catarrhalis isolates in Lebanon

First data on antimicrobial susceptibility patterns of Moraxella catarrhalis isolates in Lebanon

Epidemiology and Antibiotic Susceptibility Patterns of Carbapenem Resistant Gram Negative Bacteria Isolated from Two Tertiary Care Hospitals in North Lebanon

Prevalence of Staphylococcus aureus methicillin-sensitive and methicillin-resistant nasal carriage in food handlers in Lebanon: a potential source of transmission of virulent strains in the community

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