Prevalence and Associated Factors of Silent Brain Infarcts in a Mediterranean Cohort of Hypertensives

Delgado, Pilar; Riba‐Llena, Iolanda; Tovar, J.L.; Jarca, Carmen Ioana; Mundet, Xavier; López-Rueda, Antonio; Orfila, Francesc; Llussà, Judit; Manresa, Josep María; Álvarez-Sabín, José; Nafría, Cristina; Fernández, José Luis Fernández; Maisterra, Olga; Montaner, Joan

doi:10.1161/hypertensionaha.114.03563

Cited by 36 publications

(32 citation statements)

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“…From all participants with valid data on serum N‐glycome, 98 subjects presented 1 or more SBIs on MRI (10.1%). Among all factors associated with SBIs in the univariate analysis (Table ) and as reported before, age, male sex, and the presence of microalbuminuria were independent predictors of SBIs in our sample.…”

Section: Resultssupporting

confidence: 81%

“…A stratified randomization method was used to control for age, sex, and the center from which the subjects were recruited. Additional details on subject selection and baseline procedures have been published elsewhere …”

Section: Methodsmentioning

confidence: 99%

“…We have previously shown that urine albumin‐to‐creatinine ratio (or microalbuminuria) and lipoprotein‐associated phospholipase A 2 (Lp‐PLA 2 ) are associated with the risk of SBIs in hypertensive individuals. Subjects with microalbuminuria had twice the odds of SBIs, while Lp‐PLA 2 activity was also associated with the presence of SBIs, but only in women …”

Section: Introductionmentioning

confidence: 97%

“…Subjects with microalbuminuria had twice the odds of SBIs, while Lp-PLA 2 activity was also associated with the presence of SBIs, but only in women. 3,4 Other potentially interesting candidate biomarkers would be N-glycans. N-glycans are oligosaccharide structures covalently linked (sugar-amino acid linkage) to an asparagine residue of a protein in a consensus sequence (GlcNAc-b-Asn).…”

mentioning

confidence: 99%

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N‐glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives

Vilar-Bergua

Riba‐Llena

Vanhooren

et al. 2015

JAHA

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BackgroundSilent brain infarcts (SBIs) are highly prevalent in the aged population and relate to the occurrence of further stroke and dementia. Serum N‐glycome levels have been previously associated with aging and they might be related as well to the presence of SBIs and age‐related white matter hyperintensities.Methods and ResultsWe determined the serum N‐glycome profile in a cohort study comprising 972 subjects and evaluated the relationship between N‐glycome levels and the presence and number of SBIs and with age‐related white matter hyperintensities grades, assessed by brain magnetic resonance imaging. Decreasing concentrations of bigalacto core‐α‐1,6‐fucosylated biantennary glycan and increasing concentrations of branching α‐1,3‐fucosylated triantennary glycan remained as independent predictors of SBIs (odds ratio 0.4, 95% CI 0.3–0.7 and odds ratio 1.8, 95% CI 1–3.2, respectively), after controlling for the presence of age and classic vascular risk factors. A similar pattern was found to be related to an increasing number of SBIs and white matter hyperintensities grade.ConclusionsN‐glycome levels might be potentially useful as biomarkers for the presence of silent cerebrovascular disease.

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Section: Resultssupporting

confidence: 81%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

mentioning

confidence: 99%

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N‐glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives

Vilar-Bergua

Riba‐Llena

Vanhooren

et al. 2015

JAHA

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“…These risk factors include: age, systolic blood pressure, the use of antihypertensive therapy, diabetes mellitus, cigarette smoking, prior cardiovascular disease (coronary heart disease, cardiac failure, or intermittent claudication), atrial fibrillation, and left ventricular hypertrophy by electrocardiogram. Studies have also shown that FSRP associated with the extent of WML, with silent cerebral infarcts or microbleeds' performance in several cognitive domains and global cognitive decline . This is not surprising when taking into account the above‐mentioned association between subcortical lesions and dysfunctional cognitive domains.…”

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confidence: 86%

Searching cerebrovascular risk indicators for hypertensive patients: Is Framingham Stroke Risk Profile “the magic bullet”?

Semplicini

2018

J of Clinical Hypertension

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Arterial hypertension is one of the main risk factors for cerebrovascular diseases; even a 10% reduction of diastolic pressure offers a 40% reduction of death from cerebrovascular diseases.1 However, morbidity has not been reduced to a similar extent and an increasing number of patients suffer from recurring strokes and develop progressive cognitive impairment and dementia. Longitudinal studies have shown that arterial hypertension in adult life is a predictive factor for both vascular and degenerative dementia in the elderly and the prevention of cognitive decline and dementia is one of the main goals of antihypertensive therapy. 5 Arterial hypertension causes cognitive impairment and dementia by affecting both the large and small cerebral vessels as well as the heart. The macrovascular atherosclerotic disease causes atherothrombotic brain infarcts that can be either silent or clinically evident as stroke. The microvascular disease results in chronic ischemic changes affecting, to a large extent, the white matter, also known as white matter lesions (WML).

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Fiabilidad de la retinografía para la detección de retinopatía hipertensiva en Atención Primaria

et al. 2020

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Prevalence and Associated Factors of Silent Brain Infarcts in a Mediterranean Cohort of Hypertensives

Abstract: Abstract-Silent

Cited by 36 publications

References 44 publications

N‐glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives

N‐glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives

Searching cerebrovascular risk indicators for hypertensive patients: Is Framingham Stroke Risk Profile “the magic bullet”?

Fiabilidad de la retinografía para la detección de retinopatía hipertensiva en Atención Primaria

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