Prevalence and associated factors of obesity and overweight in Chinese patients with bipolar disorder

Yi, Wenying; Wu, Haibo; Li, Ruikeng; Li, Haijing; Song, Zhen; She, Shenglin; Zheng, Youdou

doi:10.3389/fpsyt.2022.984829

Cited by 2 publications

(2 citation statements)

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“…In China, one study found that the prevalence of obesity in patients with BD was 21%. 24 In other countries, studies have explored the prevalence of obesity in patients who were administered medication for BD. 9 Nevertheless, few studies have explored the prevalence of obesity and its risk factors in untreated BD patients.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence and Risk Factors of Comorbid Obesity in Chinese Patients with Bipolar Disorder

Wu¹,

Zhang²,

Liu³

et al. 2023

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Purpose Bipolar disorder (BD) predisposes patients to comorbid obesity and increases the risk of metabolic syndrome and cardiovascular disease. In this study, we investigated the prevalence of comorbid obesity and its risk factors in patients with BD in China. Patients and Methods We conducted a cross-sectional retrospective survey of 642 patients with BD. Demographic data were collected, physical examinations were performed, and biochemical indexes, including fasting blood glucose, alanine aminotransferase (ALT), aspartate aminotransferase, and triglycerides (TG) levels, were measured. Height and weight were measured on an electronic scale at admission, and body mass index (BMI) was in kg/m 2 . Pearson’s correlation analysis was used to analyze the correlation between BMI and variable indicators. Multiple linear regression analysis was used to analyze the risk factors for comorbid obesity in patients with BD. Results The prevalence of comorbid obesity in Chinese patients with BD was 21.3%. Obese patients had high levels of blood glucose, ALT, glutamyl transferase, cholesterol, apolipoprotein B (Apo B), TG, and uric acid in the plasma; however, the levels of high-density lipoprotein and apolipoprotein A1 were lower than those in non-obese patients. Partial correlation analysis showed that BMI was associated with ApoB, TG, uric acid, blood glucose, GGT, TC, ApoA1, HDL, and ALT levels. Multiple linear regression showed that ALT, blood glucose, uric acid, TG, and Apo B levels were important risk factors of BMI. Conclusion The prevalence of obesity is higher in patients with BD in China, and TG, blood glucose, liver enzymes, and uric acid are closely related to obesity. Therefore, more attention should be paid to patients with comorbid obesity. Patients should be encouraged to increase their physical activity, control sugar and fat intake, and reduce the prevalence of comorbid obesity and risk of serious complications.

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Section: Discussionmentioning

confidence: 99%

“… 9 In China, one study found that the prevalence of obesity in patients with BD was 21%. 24 Nevertheless, few studies have explored the prevalence of obesity and its risk factors in untreated BD patients. The prevalence and risk factors for BD with obesity differ significantly between regions and ethnic populations.…”

Section: Introductionmentioning

confidence: 99%