Prevalence and characterization of opportunistic candidal infections among patients with pulmonary tuberculosis

Astekar, Madhusudan; Bhatiya, Priyanka Sharma; Sowmya, G V

doi:10.4103/0973-029x.185913

Cited by 17 publications

(21 citation statements)

References 6 publications

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“…18 The previous study reported that pulmonary mycosis was more common in women compared to men. 21 Another study reported that more than 60% fungal culture were positive among men, 22 which is similar to our study where more number of Candida were isolated from male patients (Table 5 ). Malnutrition and long term usage of antibiotics serves as an important risk factor for fungal infection as it reduces the normal flora.…”

Section: Discussionsupporting

confidence: 88%

A bacterial and fungal profile of sputum samples in a tertiary care hospital in Puducherry

G¹,

Prabha²,

Pramodhini³

et al. 2021

IJMR

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The microscopic examination of gram stained sputum sample aids in diagnosis of patients with lower respiratory tract infections. Gram stain plays the key role in deciding the appropriateness of the quality of the sputum sample received in the laboratory for culture. It helps to determine the represent ativeness of the sample for the site of collection intended. Aim: This study was done to correlate gram stain findings with culture and to assess the use of Gram stain in sputum examination in diagnostic microbiology. Materials and Methods: During 2017 (July to December) a total of 133 sputum samples were quality assessed using Bartlett's grading system. The total scoring was done and sample showing score of 1 and above were cultured and identified based on colony characteristics, gram staining morphology and biochemical reactions. Results: One hundred and thirty-three sputum samples were collected from patients with suspected lower respiratory tract infection. Of the 133 samples, 110(79%) were accepted and 23 (21%) were found to be unacceptable by Bartlett criteria. Potential pathogens were grown in 84 samples in the acceptable category. Normal respiratory flora were grown in 26 samples. Out of 84 samples, 63 samples were positive for bacterial growth and 21 showed fungal growth. Out of 63 bacterial growth, 44 were from in-patients and 19 were from out-patients. Among these bacterial isolates, 23 isolates were Pseudomonas aeruginosa followed by 16 isolates were Klebsiella pneumoniae, 10 isolates were E.coli, 6 isolates were Staphylococcus aureus, 2 isolates were Streptococcus species, 3 isolates were Proteus mirabilis and 3 isolates were Serratia marcesens. Conclusions: All the sputum samples should be subjected to gram staining before culture to differentiate true pathogens from contaminating flora on culture.

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Section: Discussionsupporting

confidence: 88%

A bacterial and fungal profile of sputum samples in a tertiary care hospital in Puducherry

G¹,

Prabha²,

Pramodhini³

et al. 2021

IJMR

View full text Add to dashboard Cite

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“…In Asia and Africa, the co-infection rate of Aspergillus and tuberculosis is 15.4%, and it is higher in individuals above 40 years old [25]. Male tuberculosis patients are more likely to be infected with fungi, which may be related to high exposure to the surrounding environment [26]. In our study, the rate of dyspnea had a trend higher in TDL group than TDL ?…”

Section: Discussionmentioning

confidence: 44%

The Efficacy and Safety of Surgical Treatment for Patients With Tuberculosis Destroyed Lung With or Without Chronic Pulmonary Aspergillosis

2021

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Background To evaluate the efficacy and safety of surgical treatment of tuberculosis destroyed lung (TDL), and the influence of chronic pulmonary aspergillosis (CPA) on the outcomes of surgical treatment of TDL. Methods We performed a retrospective analysis of 113 patients with TDL who underwent surgical treatment from January 2005 to December 2019. Among them, 30 of these cases were complicated with CPA. The patients were divided into two groups: TDL group and TDL + CPA group. We analyzed the effectiveness and safety of surgical treatment of TDL, and further compared the effectiveness and safety of surgical treatment of TDL with or withoutthe presence of CPA. Results The TDL + CPA group had a significantly higher age (P=0.003), symptoms of hemoptysis (P=0.000), and a higher proportion of patients with preoperative serum albumin <30 g/L (P=0.014) as compared with TDL group. For all enrolled patients, the incidence of severe postoperative complications was 12.4% (14/113) and the postoperative mortality within 30 days after discharge was 4.4% (5/113). 86.7% (98/113) of the patients recovered and discharged, the incidence of severe postoperative complications in the TDA + CPA group was higher than that of TDL group (23.3% vs 8.4%, P = 0.034), although there was no difference in mortality between the two groups (P = 1.000). A binary logistic regression analysis showed that the independent risk factors for severe postoperative complications were male (OR 25.24, 95% CI 2.31–275.64; P = 0.008) and age ≥ 40 years (OR 10.34, 95% CI 1.56–68.65; P = 0.016). Conclusion Surgical treatment for patients with TDL is effective with an acceptable mortality rate whether or not the disease is complicated with CPA. The independent risk factors identified for severe postoperative complications in patients with TDL were male and ≥ 40 years old. It implies that when treating patients with TDA + CPA, particular attention should be paid to these patients who have these independent risk factors to avoid a poor outcome.

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“…Despite maintenance of overall gut microbiota diversity, studies in both, mice and men, revealed standard anti-TB therapy induced long lasting microbiota alterations including reduction of Clostridiales, Bifidobacterium and Lactobacillus amongst others [179,180]. Thus, dysbiosis, either caused by M. tuberculosis infection or antibiotic treatment, could potentially affect immune functions, enhance susceptibility to secondary infections [181][182][183][184][185][186][187] and subsequent exacerbated pathology [188,189].…”

Section: Microbiome Guided Treatment Perspectivesmentioning

confidence: 99%

Perspectives for personalized therapy for patients with multidrug‐resistant tuberculosis

et al. 2018

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According to the World Health Organization (WHO), tuberculosis is the leading cause of death attributed to a single microbial pathogen worldwide. In addition to the large number of patients affected by tuberculosis, the emergence of Mycobacterium tuberculosis drug-resistance is complicating tuberculosis control in many high-burden countries. During the past 5 years, the global number of patients identified with multidrug-resistant tuberculosis (MDR-TB), defined as bacillary resistance at least against rifampicin and isoniazid, the two most active drugs in a treatment regimen, has increased by more than 20% annually. Today we experience a historical peak in the number of patients affected by MDR-TB. The management of MDR-TB is characterized by delayed diagnosis, uncertainty of the extent of bacillary drug-resistance, imprecise standardized drug regimens and dosages, very long duration of therapy and high frequency of adverse events which all translate into a poor prognosis for many of the affected patients. Major scientific and technological advances in recent years provide new perspectives through treatment regimens tailor-made to individual needs. Where available, such personalized treatment has major implications on the treatment outcomes of patients with MDR-TB. The challenge now is to bring these adances to those patients that need them most.

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Prevalence and characterization of opportunistic candidal infections among patients with pulmonary tuberculosis

Cited by 17 publications

References 6 publications

A bacterial and fungal profile of sputum samples in a tertiary care hospital in Puducherry

A bacterial and fungal profile of sputum samples in a tertiary care hospital in Puducherry

The Efficacy and Safety of Surgical Treatment for Patients With Tuberculosis Destroyed Lung With or Without Chronic Pulmonary Aspergillosis

Perspectives for personalized therapy for patients with multidrug‐resistant tuberculosis

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