Prevalence and clinical characteristics of human metapneumovirus infections in hospitalized infants in Spain

García-García, M.L.; Calvo, Cristina; Pérez-Breña, Pilar; De, Johnstone; Acosta, Belsy; Casas, Inmaculada

doi:10.1002/ppul.20456

Cited by 97 publications

(94 citation statements)

References 40 publications

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“…8 %). A similar seasonality has been observed in studies performed in temperate regions [10,17,19,20]. An interesting finding of this study was an unusually high frequency (51 .…”

Section: Discussionsupporting

confidence: 90%

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

et al. 2008

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SUMMARYNumerous studies have been published on human metapneumovirus (HMPV) infection, but few have been population based. The main aim of this study was to estimate the incidence rate of hospitalization for community-acquired HMPV infection in infants and children aged <3 years. Between July 2004 and June 2007, 796 episodes (742 patients) of community-acquired acute respiratory infection were hospitalized. HMPV was detected in 90 episodes (11 . 3%). Fifty-nine episodes occurred in infants aged <1 year. The mean length of hospital stay was 6 . 2 days (range 2-31 days). Thirteen children required admission to the intensive care unit. Viral co-infections were detected in 46 episodes (51 . 1%). The incidence rate of hospitalization per 1000 inhabitants was 2 . 6 (95 % CI 2 . 1-3 . 2), lower than that for respiratory syncytial virus, but higher than that observed for the influenza and parainfluenza viruses. HMPV is a major respiratory pathogen that leads to a high hospitalization rate.

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“…8 %). A similar seasonality has been observed in studies performed in temperate regions [10,17,19,20]. An interesting finding of this study was an unusually high frequency (51 .…”

Section: Discussionsupporting

confidence: 90%

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

et al. 2008

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“…HBoV has also been associated with acute respiratory illnesses, predominantly among young children [131–133], and has been suggested as a potential cause of acute respiratory illnesses and recurrent wheezing episodes across several studies of preterm infants and children [134–136]. …”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased burden of viral respiratory infections is likely to have long term implications for lung health and function in individuals born preterm, particularly those with bronchopulmonary dysplasia. Several hypotheses have been put forward to explain the association between early life viral respiratory infection and development of suboptimal lung health and function later in life following preterm birth. Although preterm infants with diminished lung function, particularly small airways, might be particularly susceptible to asthma and wheezing disorders following viral infection, there is evidence that respiratory viruses can activate number of inflammatory and airway re-modelling pathways. Therefore, the aim of this review is to highlight the perinatal and early life risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants during early life and to understand how respiratory viral infection may influence the development of abnormal lung health and function later in life.

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“…Garcia-Garcia et al, 1 recently reported on their findings in a Spanish cohort of 101 pediatric patients hospitalized for HMPV-related respiratory tract infections. Although this article is highly confirmative to their previous study 2 and our matched pairs analysis, 3 it contains some interesting observations and conclusions we would like to comment on.…”

Section: Hmpv Infections Are Frequently Accompanied By Co-infectionsmentioning

confidence: 99%

HMPV infections are frequently accompanied by co‐infections

Simon

Wilkesmann

Müller

et al. 2006

Pediatric Pulmonology

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recently reported on their findings in a Spanish cohort of 101 pediatric patients hospitalized for HMPV-related respiratory tract infections. Although this article is highly confirmative to their previous study 2 and our matched pairs analysis, 3 it contains some interesting observations and conclusions we would like to comment on. As in our study, the authors have not found a significant difference in the clinical severity between HMPV and RSV-infections, although they did not used a matched pairs approach 3 but a random sample of 95 hospitalized infants-aged <2 and documented as RSV-infected. In addition, they observed a high rate (29.7%) of coinfections with at least one other viral respiratory pathogen. In earlier publications, and also in the reviewer's comments to our own publication 3 such high rates of coinfections were called 'strikingly high.' Coinfections may be detected more frequently in hospitalized patients simply as a result of a more sophisticated diagnostic approach. 5,6 In our study 3 39 patients (44.3 %) with a coinfection were observed, none of them displayed a more severe clinical course than mono-infected patients. Moreover, other studies described striking coinfection rates of up to 70% of patients, although in smaller cohorts (e.g., Ref. [4]). Most interestingly, the coinfected cohort of patients observed by Garcia-Garcia et al. also did not show a more severe clinical course. This is in contrast to earlier observations (reviewed by Kahn [5] and Schildgen et al. [6]), but in high agreement with our study. 3 This controversially discussed observation consequently has to be investigated more in detail, probably by the use of an appropriate animal model system. ACKNOWLEDGMENTS

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Prevalence and clinical characteristics of human metapneumovirus infections in hospitalized infants in Spain

Cited by 97 publications

References 40 publications

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

The impact of respiratory viruses on lung health after preterm birth

HMPV infections are frequently accompanied by co‐infections

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