Prevalence and clinical characteristics of prediabetes and diabetes mellitus in young patients with ST-segment elevation myocardial infarction

Marín, Luis Alberto Mata; Schmucker, Johannes; Fach, Andreas; Osteresch, Rico; Rühle, Stephan; Garstka, Daniela; Eitel, Ingo; Hambrecht, Rainer; Wienbergen, Harm

doi:10.1007/s00392-021-01868-1

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…There are few studies demonstrating the prevalence and importance of prediabetes in young adults who underwent CAG. Among young STEMI patients, the prevalence of prediabetes was 24% [ 7 ]. In addition, the prevalence of prediabetes was significantly higher in young patients receiving CAG compared to the corresponding age group in the general population [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Marín also found that prediabetes is common in young patients with ST-elevation myocardial infarction (STEMI). As a conventional method for diagnosis of coronary artery disease (CAD), the number of people undergoing coronary artery angiography is increasing [ 7 ], with a notable increase in young adults [ 8 ]. However, there is still a lack of research on the prevalence and impact of prediabetes on young patients undergoing CAG in China.…”

Section: Introductionmentioning

confidence: 99%

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Prediabetes and all-cause mortality in young patients undergoing coronary artery angiography: a multicenter cohort study in China

Ling

et al. 2023

Cardiovasc Diabetol

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Background The prevalence of prediabetes is increasing in young adults and patients undergoing coronary angiography. However, whether prediabetes is a considerable risk factor for all-cause mortality remains undetermined in young patients undergoing coronary angiography. Methods In this study, we retrospectively included 8868 young patients (men aged < 45 years, women aged < 55 years) who underwent coronary angiography (CAG). Patients were categorized as normoglycemic, prediabetes and diabetes according to the HbA1c level or documented history of diabetes. The association of all-cause mortality with diabetes and prediabetes was detected by Cox proportional hazards regression analysis. Results A total of 3240 (36.5%) among 8868 young patients receiving CAG were prediabetes and 2218 (25.0%) were diabetes. 728 patients died during a median follow-up of 4.92 years. Compared to the normoglycemic group, prediabetes increased the risk of all-cause mortality in young CAG patients by 24%(adjusted HR: 1.24, 95% CI: 1.04–1.49, p = 0.019) and diabetes increased the risk of all-cause mortality by 46%(adjusted HR:1.46, 95% CI:1.2–1.79, p < 0.001). Subgroup analysis showed that diabetes and prediabetes increased the risk of death mainly in patients without comorbidities. Conclusion Prediabetes accounts for more than one-third of the young adults undergoing CAG and was associated with an increased risk of all-cause mortality, active prevention strategy should be considered for these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prediabetes and all-cause mortality in young patients undergoing coronary artery angiography: a multicenter cohort study in China

Ling

et al. 2023

Cardiovasc Diabetol

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“…Despite the accumulating evidence suggesting an association between elevated levels of HbA1c and DM with a poor outcome in premature AMI patients [30][31][32], the target of HbA1c in premature CAD patients undergoing PCI has not been well established. Alfredo Caturano et al [33] reviewed the potential mechanism of strict glycemic control in cardiovascular protection in patients with acute coronary syndrome, mainly including anti-apoptotic actions, anti-inflammatory effects, increasing nitric oxide, reducing plasma level of free fat acid, etc.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the accumulating evidence suggesting an association between elevated levels of HbA1c and DM with a poor outcome in premature AMI patients [ 30 , 31 , 32 ], the target of HbA1c in premature CAD patients undergoing PCI has not been well established. Alfredo Caturano et al .…”

Section: Discussionmentioning

confidence: 99%

Intermediate Hyperglycemia Increases the Risk of All-Cause Mortality in Premature Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention

Zhou,

Qiao,

Ling

et al. 2023

Rev. Cardiovasc. Med.

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Background: Hyperglycemia has been associated with an adverse prognosis in patients with premature coronary artery disease (CAD). However, whether the intermediate hyperglycemia status affects the risk of mortality in premature CAD patients treated with percutaneous coronary intervention (PCI), remains unclear. Methods: We retrospectively included 14,585 premature CAD patients undergoing PCI from 2007 to 2020. Patients were divided into normal glycemia (<6%), intermediate hyperglycemia (6%-6.5%), and hyperglycemia (≥6.5%) according to hemoglobin A1c (HbA1c) level in whole blood. Follow-up all-cause mortality was defined as a primary outcome, and Cox proportional regression analysis was used to assess the association between glycemia status and the primary outcome. Results: Among 14,585 premature CAD patients undergoing PCI (mean age 43.6 ± 7.6 years, 28.1% female), 2856 (19.6%) were diagnosed with intermediate hyperglycemia. Over a median follow-up of 4.62 years (2.72-7.19 years), patients with hyperglycemia were correlated with higher risk (hazard ratio [HR] 1.35, 95% confidence interval [CI] 1.19-1.54, p < 0.001) while patients with intermediate hyperglycemia were associated with intermediate mortality risk from all causes (HR 1.17, 95% CI 1.0-1.36, p = 0.049). Conclusions: Intermediate hyperglycemia was positively associated with all-cause mortality risk in patients with premature CAD undergoing PCI. Active glucoselowering therapy may be considered in these patients. Clinical Trial Registration: NCT05050877.

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“…Сахарный диабет, как известно, способствует прогрессированию атеросклероза коронарных артерий. Доказано, что наличие сахарного диабета и/или ожирения у молодых людей приводит к более тяжелому течению ИБС и развитию инфаркта миокарда [10].…”

Section: результаты исследования и их обсуждениеunclassified

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2024

EJNH

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The journal is based in 2005 Двухлетний импакт-фактор РИНЦ = 0,301 Пятилетний импакт-фактор РИНЦ = 0,120 Журнал ЕВРОПЕЙСКИЙ ЖУРНАЛ ЕСТЕСТВОЗНАНИЯ зарегистрирован Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций. Свидетельство ПИ № ФС 77-19917. EUROPEAN JOURNAL OF NATURAL HISTORY Журнал включен в Реферативный журнал и Базы данных ВИНИТИ. Сведения о журнале ежегодно публикуются в международной справочной системе по периодическим и продолжающимся изданиям «Ulrich's Periodicals directory» в целях информирования мировой научной общественности. Журнал представлен в ведущих библиотеках страны и является рецензируемым. Журнал представлен в НАУЧНОЙ ЭЛЕКТРОННОЙ БИБЛИОТЕКЕ (НЭБ)головном исполнителе проекта по созданию Российского индекса научного цитирования (РИНЦ) и имеет импакт-фактор Российского индекса научного цитирования (ИФ РИНЦ).

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Prevalence and clinical characteristics of prediabetes and diabetes mellitus in young patients with ST-segment elevation myocardial infarction

Cited by 5 publications

References 23 publications

Prediabetes and all-cause mortality in young patients undergoing coronary artery angiography: a multicenter cohort study in China

Prediabetes and all-cause mortality in young patients undergoing coronary artery angiography: a multicenter cohort study in China

Intermediate Hyperglycemia Increases the Risk of All-Cause Mortality in Premature Coronary Artery Disease Patients Undergoing Percutaneous Coronary Intervention

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