Prevalence and clinical characteristics of rotavirus diarrhea in Mataram, Lombok, Indonesia

Parwata, Wayan Sulaksmana Sandhi; Sukardi, Wayan; Wahab, Abdul; Soenarto, Yati

doi:10.14238/pi56.2.2016.118-23

Cited by 9 publications

(11 citation statements)

References 8 publications

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“…20 A hospital based surveillance in Mataram (2010) revealed positive rate of 63.8%. 25 Similarly, a hospital based study in Riau (2015) reported detection rate of 62%. 31 During outbreak period in Lampung (2016 and 2018), positive rate of 74 samples collected from hospital and community was 74.3%.…”

Section: The Detection Rate Of Rotavirus Infection In Indonesiamentioning

confidence: 97%

“…The G genotypes of rotavirus found among children with rotavirus diarrhoea and their percentage in Indonesia during 2003-2018. Data generated from 18 studies, *: denotes the same origin of study (3 separated data from one study conducted by Nirwati et al, in the year of 2006, 2009, and 2010) 3,7,15,16,17,18,19,20,21,22,24,25,29,31,32,33,34,35.…”

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confidence: 99%

“…The frequent clinical features (diarrhoea, vomiting and fever) observed in rotavirus patient in Indonesia from various studies conducted during 1984-2018. Each study indicates percentage of clinical features among rotavirus patients and the year of study period(The year of study conducted is indicated in the brackets) 8,10,13,15,16,17,18,20,21,23,25,28,29,30,32,33,35. FIGURE 4.…”

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confidence: 99%

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The rotavirus causing acute gastroenteritis in children of under 5-year of age in Indonesia 1972-2018: a review

Aman

2021

JMedScie

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The reason of this review is the absence of thorough information of rotavirus infection that had been the major cause of severe diarrhea in children of under 5-years of age in Indonesia, despite numerous publications elaborating rotavirus infection in some geographic areas of Indonesia. A review was conducted towards 52 published articles covering rotavirus research in Indonesia during period of 1972-2018.A thirty three selected articles were match with review criteria which comprises rotavirus positive rate, clinical features, and severity of rotavirus infection, as well as genotypes of the rotavirus. Rotavirus has been known as the major cause of severe diarrhea among children under 5 years of age world wide including in Indonesia. The rotavirus positive rates were range from 31.1 to 90.9%, which variably to different subject's population, study criteria and methods, and time. Rotavirus can cause severe diarrhea with majority of infected children suffered from dehydration, vomiting, and fever. The first genotyping conducted in Indonesia in the early 1980s revealed the predominant genotypes were G3 and G4, followed by G2, and small proportion of G1 and mixed genotypes. However the following decades G1 and G2 were on the raise with G3 predominantly re-appeared on 2015. G9 was first identified in 2004, and occasionally detected until 2015. The P genotyping revealed P[4], P[6], and P[8] were the common genotypes detected. Mixed and untyped genotypes were also detected in various proportion. Rotavirus diarrhea is a vaccination preventable disease, after natural infection, the immune system will produce protective antibodies that will protect from infection of both homotypic and heterotypic, however homotypic infection will protect stronger. Therefore this review recommends continuous rotavirus genotypes surveillance in Indonesia. ABSTRAKReview ini untuk menjawab ketiadaan informasi yang komprehensif tentang infeksi rotavirus penyebab diare berat pada anak-anak berusia kurang dari 5 tahun di Indonesia, meskipun berbagai publikasi memberikan informasi mengenai infeksi rotavirus di beberapa wilayah di Indonesia. Review dilakukan pada 52 artikel tentang penelitian rotavirus di Indonesia periode tahun 1972-2018. Sebanyak 33 naskah sesuai dengan kriteria yang mencakup rotavirus positive rate, manifestasi klinis, derajat keparahan infeksi rotavirus, dan genotipe rotavirus. Rotavirus diketahui sebagai penyebab utama diare pada anak di dunia termasuk di Indonesia. Rotavirus positive rate berkisar antara 31,1 sampai 90,9%, bervariasi tergantung populasi subyek penelitian, waktu, metode dan kriteria penelitian. Rotavirus dapat menyebabkan diare berat, dengan mayoritas anak yang terinfeksi mengalami dehidrasi, muntah, dan demam. Genotyping yang pertama dilakukan di Indonesia pada awal 1980 menunjukkan adanya genotipe yang predominan adalah G3 dan G4, kemudian diikuti oleh G2, dengan sedikit proporsi genotipe G1 dan campuran. Meskipun demikian, studi pada dekade berikutnya menunjukkan naiknya proporsi G1 dan G2, dengan G3 yang k...

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Section: The Detection Rate Of Rotavirus Infection In Indonesiamentioning

confidence: 97%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The rotavirus causing acute gastroenteritis in children of under 5-year of age in Indonesia 1972-2018: a review

Aman

2021

JMedScie

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“…RVA infection causes severe acute gastroenteritis among children and is responsible for approximately 60% of inpatients and 41% of outpatients in pediatric hospitals, respectively ( Nirwati et al, 2017 ; Utsumi et al, 2018 ). RVA is responsible for 2% mortality of all causes in children under 5 years old in Indonesia ( Parwata et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Distribution of Rotavirus Genotypes Among Children With Acute Gastroenteritis in Areas Other Than Java Island, Indonesia, 2016–2018

et al. 2021

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Group A rotaviruses (RVAs) are the leading cause of acute gastroenteritis, which is often associated with severe symptoms in children under 5 years old. Genetic reassortments and interspecies transmission commonly occur, resulting in a great diversity of RVA circulating in the world. The aim of this study is to determine the prevalence and distribution of RVA genotypes among children in Indonesia over the years 2016–2018 across representative areas of the country. Stool samples were collected from 202 pediatric patients with acute gastroenteritis in three regions of Indonesia (West Nusa Tenggara, South Sumatra, and West Papua) in 2016–2018. Rotavirus G and P genotypes were determined by reverse transcription PCR (RT-PCR) and direct sequencing analysis. The prevalences of RVA in South Sumatra (55.4%) and West Papua (54.0%) were significantly higher than that in East Java (31.7%) as determined in our previous study. The prevalence in West Nusa Tenggara (42.6%) was the lowest among three regions, but higher than that in East Java. Interestingly, equine-like G3 rotavirus strains were found as predominant strains in South Sumatra in 2016 and in West Papua in 2017–2018. Moreover, the equine-like G3 strains in South Sumatra detected in 2016 were completely replaced by human G1 and G2 in 2018. In conclusion, RVA infection in South Sumatra and West Papua was highly endemic. Equine-like G3 strains were also spread to South Sumatra (West Indonesia) and West Papua (East Indonesia), as well as Java Island. Dynamic change in rotavirus genotypes from equine-like G3 to human genotypes was also observed. Continuous monitoring may be warranted in isolated areas in Indonesia.

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“…A large proportion, 55% in Asia, and 32% in Africa, of acute watery diarrhea hospitalizations and 28% of watery diarrhea deaths are due to rotavirus [3]. The Indonesian Rotavirus Surveillance Network (IRSN) conducted hospital-based surveillance studies across Indonesia from 1978 -2015 and found 38% -62% of watery diarrhea was caused by rotavirus [4], [5], [6], [7]. The estimated total direct medical costs of rotavirus outpatient and inpatient hospitalizations in Indonesia amount to US$16.7million per year [8].…”

Section: Introductionmentioning

confidence: 99%

Knowledge and Attitudes Towards Rotavirus Diarrhea and the Acceptance of Rotavirus Vaccination Amongst Primary Caregivers in Yogyakarta, Indonesia: A Qualitative Study

Sitaresmi

Holly

Heywood

et al. 2021

Preprint

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Background: Rotavirus is the leading cause of hospitalized diarrhea in Indonesia. Rotavirus vaccine has not been included on the Indonesian National Immunization Program (NIP). There are some key issues must be considered before introducing a new vaccine into a NIP. Our study aimed to explore the knowledge and attitudes of rotavirus diarrhea and barriers to the acceptance of the vaccine. Methods: We conducted 26 in-depth interviews in two districts (rural and urban areas) of Yogyakarta Province, Indonesia. Participants included pregnant women in their third trimester and mothers of infants aged less than 14 weeks. We conducted a thematic analysis. Results: Participants did not perceive diarrhea as being a priority health problem. Very few had heard of rotavirus diarrhea or were aware of the availability of the vaccine. While participants would accept a vaccine their children against rotavirus, some key barriers impacted the use of the vaccine. As the rotavirus vaccine is not included in the Indonesian National Immunisation Program (NIP), parents perceived it as not essential. Parents were concerned regarding the safety and benefit of the vaccine due to the perceived newness of the vaccine. Other concerns were the vaccine was too costly and the halal issue. Participants expressed a need for more information on the vaccine's effectiveness and safety, with their primary health care providers (HCPs) nominated as playing an important role in vaccine acceptance. Conclusions: There was low awareness of rotavirus being a serious disease and the availability of the rotavirus vaccine in Indonesia. The vaccine is not on the Indonesian NIP, the newness, the safety and efficacy, the cost, and the halal status of vaccine were barriers to vaccine acceptance. Information and recommendation by HCPs play an essential role in vaccine acceptance

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Prevalence and clinical characteristics of rotavirus diarrhea in Mataram, Lombok, Indonesia

Abstract: Background Rotavirus is the most common cause of severe

Cited by 9 publications

References 8 publications

The rotavirus causing acute gastroenteritis in children of under 5-year of age in Indonesia 1972-2018: a review

The rotavirus causing acute gastroenteritis in children of under 5-year of age in Indonesia 1972-2018: a review

Prevalence and Distribution of Rotavirus Genotypes Among Children With Acute Gastroenteritis in Areas Other Than Java Island, Indonesia, 2016–2018

Knowledge and Attitudes Towards Rotavirus Diarrhea and the Acceptance of Rotavirus Vaccination Amongst Primary Caregivers in Yogyakarta, Indonesia: A Qualitative Study

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