Prevalence and Clinical Disease Severity of Respiratory Coinfections During the Coronavirus Disease 2019 Pandemic

Weidmann, Maxwell D.; Berry, Gregory J.; Green, Daniel A.; Wu, Fann

doi:10.1016/j.yamp.2022.07.003

Cited by 3 publications

(2 citation statements)

References 65 publications

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“…Among cases of coinfections, 80% involved dual infections, while 20% involved triple infections. The pathogenic mechanisms of coinfections are often facilitated by a synergistic viral effect, and in some cases, coinfections may increase the risk of complications and severe clinical features [35,36]. It is noteworthy that coinfections are commonly observed in respiratory tract infections, especially in children [37,38].…”

Section: Discussionmentioning

confidence: 99%

Acute Respiratory Tract Infections (ARTIs) in Children after COVID-19-Related Social Distancing: An Epidemiological Study in a Single Center of Southern Italy

Falsaperla,

Sortino,

La Cognata

et al. 2024

Diagnostics

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In Sicily (Italy), respiratory syncytial virus (RSV), rhinovirus (HRV), and influenza virus triggered epidemics among children, resulting in an increase in acute respiratory tract infections (ARTIs). Our objective was to capture the epidemiology of respiratory infections in children, determining which pathogens were associated with respiratory infections following the lockdown and whether there were changes in the epidemiological landscape during the post-SARS-CoV-2 pandemic era. Materials and Methods: We analyzed multiplex respiratory viral PCR data (BioFire® FilmArray® Respiratory Panel 2.1 Plus) from 204 children presenting with respiratory symptoms and/or fever to our Unit of Pediatrics and Pediatric Emergency. Results: Viruses were predominantly responsible for ARTIs (99%), with RSV emerging as the most common agent involved in respiratory infections, followed by human rhinovirus/enterovirus and influenza A. RSV and rhinovirus were also the primary agents in coinfections. RSV predominated during winter months, while HRV/EV exhibited greater prevalence than RSV during the fall. Some viruses spread exclusively in coinfections (human coronavirus NL63, adenovirus, metapneumovirus, and parainfluenza viruses 1–3), while others primarily caused mono-infections (influenza A and B). SARS-CoV-2 was detected equally in both mono-infections (41%) and coinfections (59%). Conclusions: Our analysis underlines the predominance of RSV and the importance of implementing preventive strategies for RSV.

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Section: Discussionmentioning

confidence: 99%

Acute Respiratory Tract Infections (ARTIs) in Children after COVID-19-Related Social Distancing: An Epidemiological Study in a Single Center of Southern Italy

Falsaperla,

Sortino,

La Cognata

et al. 2024

Diagnostics

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“…It is expected that as countries decrease the implementation of restricting measures, SARS-CoV-2 will circulate with other respiratory viruses, increasing the probability of co-infections especially during the next winter seasons. Indeed, the actual co-infection rates may already be higher than believed [ 35 , 36 ]. The severity of these co-infections is difficult to predict but recent data suggest cautiousness (including vaccinations and syndromic testing) mostly for influenza/SARS-CoV-2 co-infections [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Performance Evaluation of the NeuMoDx Flu A-B/RSV/SARS-CoV-2 Vantage Assay

et al. 2022

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SARS-CoV-2 infections may present with various symptoms that are similar to those of other respiratory diseases. For this reason, the need for simultaneous detection of at least RSV and influenza viruses together with SARS-CoV-2 was evident from the early stages of the pandemic. In the present study, we evaluated the clinical performance of the NeuMoDx™ Flu A-B/RSV/SARS-CoV-2 Vantage Assay against the conventional low-plex PCR utilized to detect influenza A-B, RSV, and SARS-CoV-2. There were 115 known positive clinical samples and 35 negative controls obtained from asymptomatic health-care workers included in the study; 25 samples were positive for influenza viruses, 46 for RSV, and 44 for SARS-CoV-2. The sensitivity, specificity, positive predictive value, and negative predictive value of the evaluated method for influenza and SARS-CoV-2 were 100%. The Spearman correlation coefficient was 0.586 (p < 0.05) for influenza and 0.893 (p < 0.05) for SARS-CoV-2. The sensitivity of the aforementioned assay for RSV was 93.47%; the specificity and the positive predictive value were 100%, and the negative predictive value was 92.10%, while the Spearman correlation coefficient was not applicable for the RSV. Overall, the assay under evaluation was shown to be a reliable alternative for the simultaneous detection of influenza viruses, RSV and SARS-CoV-2.

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Respiratory tract infections: an update on the complexity of bacterial diversity, therapeutic interventions and breakthroughs

Panickar,

Manoharan,

Anbarasu

et al. 2024

Arch Microbiol

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Prevalence and Clinical Disease Severity of Respiratory Coinfections During the Coronavirus Disease 2019 Pandemic

Cited by 3 publications

References 65 publications

Acute Respiratory Tract Infections (ARTIs) in Children after COVID-19-Related Social Distancing: An Epidemiological Study in a Single Center of Southern Italy

Acute Respiratory Tract Infections (ARTIs) in Children after COVID-19-Related Social Distancing: An Epidemiological Study in a Single Center of Southern Italy

Clinical Performance Evaluation of the NeuMoDx Flu A-B/RSV/SARS-CoV-2 Vantage Assay

Respiratory tract infections: an update on the complexity of bacterial diversity, therapeutic interventions and breakthroughs

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