Prevalence and clinical significance of totally occluded infarct-related arteries in patients with non-ST-segment elevation acute coronary syndromes

Almendro‐Delia, Manuel; Garcia, T Seoane; Calle, Pablo Villar; Garcia-Gonzalez, N; López, Beatriz; Cortés, Felipe; Río, Manuel García del; García, María del Pilar Ruiz; Urbano, Rafael; Garcı́a-Rubira, Juan C.

doi:10.1016/j.ijcard.2020.09.040

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…The overall long-term mortality was low and did not differ between study groups. A similar result, albeit based on much shorter follow-up, was recently reported based on registry analyses 35 . Nevertheless, not surprisingly, patients with pre-PPCI TIMI flow grade 3 showed a strong trend towards better survival which demonstrated the clinical difference between NSTEMI and a complete coronary flow restoration.…”

Section: Discussionsupporting

confidence: 86%

Primary percutaneous coronary intervention is appropriate in transient ST-elevation myocardial infarction

Koc¹,

Mikolášková²,

Novotný³

et al. 2022

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Introduction.Reperfusion therapy by primary percutaneous coronary intervention (PPCI) is generally indicated in patients suffering from acute myocardial infarction (MI) with ST-segment elevation (STEMI). Prior to hospital admission, full ST-segment resolution (fSTR) may occur. Optimal management of such patients with transient STEMI (TSTEMI) is potentially challenging. Our aim was to evaluate the hypothesis that in TSTEMI patients, patency of infarct related artery (IRA) is achieved before PPCI, and to compare the outcome of TSTEMI and STEMI patients during a prolonged follow-up. Material and Methods. Three hundred consecutive adult STEMI patients were referred to catheterization laboratory. In all patients, standard 12 lead ECGs were obtained both at the time of the first medical contact, and on catheterization laboratory admission. Results. TSTEMI occurred in 20 patients (6.7%). Despite fSTR (isoelectric ST segment), occluded IRA was found in 5 of these patients (25%). Pre-PPCI TIMI flow grade 2 was found in 6 TSTEMI patients (30%). Troponin T value at 24 h after symptom onset was lower in the TSTEMI group (1.8±2.5 mg/L vs. 3.6±3.5 mg/L, P=0.008). These patients also had a lower value of brain natriuretic peptide (156.3±119.5 ng/L vs. 438.5±429.0 ng/L, P<0.001) and higher left ventricular ejection fraction (59.9±6.3% vs. 51.6±10.2%, P<0.001). All patients were followed for a median of 5.6 years during which the overall survival did not differ between the TSTEMI and STEMI groups. Conclusion. Primary PCI is strongly recommended in TSTEMI patients because of a relatively high incidence of occluded infarct related arteries. The rate of patients with TSTEMI is relatively low.

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Section: Discussionsupporting

confidence: 86%

Primary percutaneous coronary intervention is appropriate in transient ST-elevation myocardial infarction

Koc¹,

Mikolášková²,

Novotný³

et al. 2022

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Single-vessel disease was defined as at least 50% stenosis in one major coronary artery [ 23 ]. Multivessel disease was defined as at least two major vessels (≥ 2 mm diameter) from different territories with lesions deemed angiographically significant (≥ 50% stenosis) [ 4 , 24 ]. A 50% or more reduction in the internal diameter of the left main coronary artery was considered to be three-vessel disease [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Association between triglyceride glucose index, coronary artery calcification and multivessel coronary disease in Chinese patients with acute coronary syndrome

Wang

Sheng

et al. 2022

Cardiovasc Diabetol

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Background Multivessel coronary disease (MVCD) is the common type of coronary artery disease in acute coronary syndrome (ACS). Coronary artery calcification (CAC) has been confirmed the strong predictor of major adverse cardiovascular events (MACEs). Several studies have validated that triglyceride glucose (TyG) index can reflect the degree of coronary calcification or predict MACEs. However, no evidence to date has elucidated and compared the predictive intensity of TyG index or/and coronary artery calcification score (CACS) on multi-vascular disease and MACEs in ACS patients. Methods A total of 935 patients, diagnosed with ACS and experienced coronary computed tomography angiography (CCTA) from August 2015 to March 2022 in the Second Hospital of Shandong University, were selected for retrospective analysis. The subjects were divided into TyG index quartile 1–4 groups (Q1-Q4 groups), non-multivessel coronary disease (non-MVCD) and multivessel coronary disease (MVCD) groups, respectively. The general data, past medical or medication history, laboratory indicators, cardiac color Doppler ultrasound, CACS, and TyG indexes were respectively compared among these groups. The ROC curve preliminarily calculated and analyzed the diagnostic value of TyG index, CACS, and the combination of the two indicators for MVCD. Univariate and multivariate logistic regression analysis discriminated the independent hazard factors for forecasting MVCD. Results Compared with the lower TyG index and non-MVCD groups, the higher TyG index and MVCD groups had higher values of age, smoking history, waist circumference, systolic blood pressure, low-density lipoprotein cholesterol(LDL-C), fasting blood glucose and glycosylated hemoglobin, and CACS, but lower values of high-density lipoprotein cholesterol(HDL-C) (all P < 0.01). Coronary artery calcification is more common in the left anterior descending artery. Compared with non-MVCD, each unit increase in TyG index was associated with a 1.213-fold increased risk of MVCD. Logistic regression analysis adjusted for potential confounders indicated that TyG index is an independent risk factor for MVCD. With the increase of TyG index, the incidence of MACEs, apart from all-cause death, cardiac death, unexpected re-hospitalization of heart failure, recurrent ACS or unplanned revascularization, and non-fatal stroke in coronary artery increased ( P log-rank < 0.001). Conclusion TyG index could completely substitute for CACS as a reliable, practical, and independent indicator for predicting the severity and prognosis of MVCD in patients with ACS.

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“…There has been concern that a significant portion of patients not presenting with STEMI ECGs show an acute coronary occlusion in coronary angiography [ 37 , 38 , 39 , 40 ]. A recent study compared STEMI ECGs and non-STEMI ECGs for patients with acute coronary occlusion on coronary angiography and found that ED arrival to catheterization time is significantly delayed in patients with non-STEMI ECGs, while adverse outcomes are similar between the two groups [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Comparing Door-To-Balloon Time between ST-Elevation Myocardial Infarction Electrocardiogram and Its Equivalents

Choi

Kim

et al. 2022

JCM

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Background: In patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary interventions (pPCI), longer door-to-balloon (DTB) time is known to be associated with an unfavorable outcome. A percentage of patients with acute coronary occlusion present with atypical electrocardiographic (ECG) findings, known as STEMI-equivalents. We investigated whether DTB time for STEMI-equivalent patients was delayed. Methods: This is a retrospective study including patients arriving at an emergency department with the acute coronary syndrome in whom emergent pPCI was performed. ECGs were classified into STEMI and STEMI-equivalent groups. We compared DTB time, with its components, between the groups. We also investigated whether STEMI-equivalent ECG was an independent predictor of DTB time delayed for more than 90 min. Results: A total of 180 patients were included in the present study, and 23 patients (12.8%) presented with STEMI-equivalent ECGs. DTB time was significantly delayed in patients with STEMI-equivalent ECGs (89 (80–122) vs. 81 (70–88) min, p = 0.001). Multivariable logistic regression analysis showed that STEMI-equivalent ECG was an independent predictor of delayed DTB time (odds ratio: 4.692; 95% confidence interval: 1.632–13.490, p = 0.004). Conclusions: DTB time was significantly delayed in patients presenting with STEMI-equivalent ECGs. Prompt recognition of STEMI-equivalent ECGs by emergency physicians and interventional cardiologists might reduce DTB time and lead to a better clinical outcome.

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Prevalence and clinical significance of totally occluded infarct-related arteries in patients with non-ST-segment elevation acute coronary syndromes

Cited by 4 publications

References 28 publications

Primary percutaneous coronary intervention is appropriate in transient ST-elevation myocardial infarction

Primary percutaneous coronary intervention is appropriate in transient ST-elevation myocardial infarction

Association between triglyceride glucose index, coronary artery calcification and multivessel coronary disease in Chinese patients with acute coronary syndrome

Comparing Door-To-Balloon Time between ST-Elevation Myocardial Infarction Electrocardiogram and Its Equivalents

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