Prevalence and Cluster of Cardiometabolic Biomarkers in Overweight and Obese Schoolchildren: Results from a Large Survey in Southwest Germany

Abstract

BACKGROUND:Obesity is associated with substantial metabolic changes and subclinical inflammation. We explored associations between body mass index (BMI) and cardiometabolic biomarkers and their clustering in overweight and obese schoolchildren.

Independent associations between cardiorespiratory fitness, waist circumference, BMI, and clustered cardiometabolic risk in adolescents

“…However, this was not apparent in this study. Previous studies have been contradictory in their findings concerning the levels of IL-6 in the presence of obesity with some demonstrating elevated levels (Balagopal et al, 2005;Nagel et al, 2008) whilst others have not (Caballero et al, 2008;Valle Jimenez et al, 2007). Given these contradictory findings it is difficult to establish the associations between IL-6 and adiposity in youth Model 1 is adjusted for sex, age, physical activity and maturation status.…”

Sociocultural Influence on Obesity and Lifestyle in Children: A Study of Daily Activities, Leisure Time Behavior, Motor Skills, and Weight Status

“…Also, there is a rising prevalence of the metabolic syndrome in the pediatric population [12]. Additionally, excess weight in children and adolescents has been shown to be associated with patterns of unfavorable metabolic markers during adolescence [13], suggesting that it might not only promote cardiovascular disease later in life but could also be associated with an early initiation of atherosclerosis. …”

Elevated glucose level at 30 minutes during an oral glucose tolerance test in obese adolescents: a new disorder of glucose tolerance

“…We did not compare obese patients to healthy subjects. Despite lack of knowledge of effects of Lp-PLA 2 in obesity, a large number of prospective studies conducted in initially healthy subjects and on patients with manifest atherosclerosis have documented, Lp-PLA 2 activity was associated with increased cardiovascular risk, suggesting a proatherogenic activity [16,36]. We found elevated Lp-PLA 2 levels and a positive relationship with the degree of obesity in participants with the elevated glucose levels at 30 min.…”

“…Moreover, in adults, elevated Lp-PLA 2 is accepted as a cardiovascular risk marker independent of traditional risk factors such as increased low density lipoprotein cholesterol (LDL-C) and CRP [15]. However, studies in obese children regarding neopterin and Lp-PLA 2 levels are few in numbers [16,17]. Persistent inflammation in obese children may increase the risks of metabolic and cardiovascular events later in life [11].…”