Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis

Simon, Viktória; Czobor, Pál; Bálint, Sára; Mészáros, Ágnes; Bitter, István

doi:10.1192/bjp.bp.107.048827

Cited by 1,321 publications

(1,014 citation statements)

References 56 publications

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“…Attention-Deficit/Hyperactivity Disorder (ADHD) is one of the most prevalent psychiatric disorders in childhood , whichFin contrast to previous assumptionsFoften persists into adolescence and adulthood (Barkley, 1998;Simon et al, 2009). A plethora of family, adoption, and twin studies show that heritability has a major role (see references Biederman, 2005;Faraone et al, 2005;Faraone and Doyle, 2000;Martin et al, 2002) as up to 80% of the phenotypic variability can be explained by genetic influence (eg, Faraone and Doyle, 2000;Levy et al, 1997).…”

Section: Introductionmentioning

confidence: 88%

Dopamine Transporter (SLC6A3) Genotype Impacts Neurophysiological Correlates of Cognitive Response Control in an Adult Sample of Patients with ADHD

Dresler

Ehlis

Renner

et al. 2010

Neuropsychopharmacol

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Studies provide ample evidence for a dysfunction in dopaminergic neurotransmission in Attention-Deficit/Hyperactivity Disorder (ADHD). In that respect, a common variable number of tandem repeats (VNTR) polymorphism in the 3 0 untranslated region (UTR) of the dopamine transporter gene (SLC6A3) has been repeatedly associated with the disorder. Here, we examined the influence of the common 9-and 10-repeat alleles of SLC6A3 on prefrontal brain functioning and cognitive response control in a large sample of adult ADHD patients (n ¼ 161) and healthy controls (n ¼ 109). To this end, we inspected a neurophysiological marker of cognitive response control (NoGo anteriorization, NGA) elicited by means of a Go-NoGo task (continuous performance test, CPT). Within the group of ADHD patients, nine-repeat allele carriers showed significantly reduced NGA, whereas no influence of SLC6A3 genotype was observed in the control group. In contrast to previous association studies of children, the nine-repeatFnot the 10-repeatFallele was associated with functional impairments in our sample of adult ADHD patients. Our findings confirm a significant effect of the SLC6A3 genotype on the neurophysiological correlates of cognitive response control in ADHD, and indicate that still to-be-identified age-related factors are important variables modulating the effect of genetic factors on endophenotypes.

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Section: Introductionmentioning

confidence: 88%

Dopamine Transporter (SLC6A3) Genotype Impacts Neurophysiological Correlates of Cognitive Response Control in an Adult Sample of Patients with ADHD

Dresler

Ehlis

Renner

et al. 2010

Neuropsychopharmacol

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“…Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental condition behaviourally defined by patterns of persistent age inappropriate inattention, hyperactivity and impulsivity [1], affecting 3-7% of children and adults worldwide [2][3][4][5]. ADHD is also characterized by cognitive difficulties [6], and impacts significantly on management of daily routines [7], school [8], work [9] and social relationships [10].…”

Section: Introductionmentioning

confidence: 99%

An international clinical study of ability and disability in ADHD using the WHO-ICF framework

Mahdi

Ronzano

Knüppel

et al. 2018

Eur Child Adolesc Psychiatry

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This is the fourth and final study designed to develop International Classification of Functioning, Disability and Health (ICF, and children and youth version, ICF-CY) core sets for attention-deficit hyperactivity disorder (ADHD). To investigate aspects of functioning and environment of individuals with ADHD as documented by the ICF-CY in clinical practice settings. An international cross-sectional multi-centre study was applied, involving nine units from eight countries: Denmark, Germany, India, Italy, Portugal, Saudi Arabia, Sweden and Taiwan. Clinicians and clinical researchers rated the functioning level of 112 children, adolescents and adults with ADHD using the extended ICF-CY checklist version 2.1a. The ratings were based on a variety of information sources, such as medical records, medical history, clinical observations, clinical questionnaires, psychometric tests and structured interviews with participants and family members. In total, 113 ICF-CY categories were identified, of which 50 were related to the activities and participation, 33 to environmental factors and 30 to body functions. The clinical study also yielded strengths related to ADHD, which included temperament and personality functions and recreation and leisure. The study findings endorse the complex nature of ADHD, as evidenced by the many functional and contextual domains impacted in ADHD. ICF-CY based tools can serve as foundation for capturing various functional profiles and environmental facilitators and barriers. The international nature of the ICF-CY makes it possible to develop user-friendly tools that can be applied globally and in multiple settings, ranging from clinical services and policymaking to education and research.

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“…It has a prevalence of 5-8% in childhood (Bush, 2010), and persists in adulthood in 60% of the cases with an established prevalence of 2.5-4.9%, (Simon et al, 2009). Depending on the presence and severity of ADHD cardinal symptoms (i.e., hyperactivity, impulsiveness and inattention), predominantly hyperactive/impulsive, inattentive and combined subtypes have been described Fried et al, 2006;Babinski et al, 2011;Doshi et al, 2012;Chang et al, 2014;Ginsberg et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults

Hasler

Preti

Meskaldji

et al. 2017

Psychiatry Research: Neuroimaging

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A B S T R A C TAttention deficit hyperactivity disorder (ADHD) is accompanied by resting-state alterations, including abnormal activity, connectivity and asymmetry of the default-mode network (DMN). Concurrently, recent studies suggested a link between ADHD and the presence of polymorphisms within the gene BAIAP2 (i.e., brain-specific angiogenesis inhibitor 1-associated protein 2), known to be differentially expressed in brain hemispheres. The clinical and neuroimaging correlates of this polymorphism are still unknown. We investigated the association between BAIAP2 polymorphisms and DMN functional connectivity (FC) asymmetry as well as behavioral measures in ADHD adults. Resting-state fMRI was acquired from 30 ADHD and 15 healthy adults. For each subject, rs7210438 and rs8079626 within the gene BAIAP2 were genotyped. ADHD severity, impulsiveness and anger were assessed for the ADHD group. Using multivariate analysis of variance, we found that genetic features do have an impact on DMN FC asymmetry. In particular, polymorphism rs8079626 affects medial frontal gyrus and inferior parietal lobule connectivity asymmetry, lower for AA than AG/GG carriers. Further, when combining FC asymmetry and the presence of the rs8079626 variant, we successfully predicted increased externalization of anger in ADHD. In conclusion, a complex interplay between genetic vulnerability and interhemispherical DMN FC asymmetry plays a role in emotion regulation in adult ADHD.

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Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis

Abstract: Prevalence of ADHD in adults declines with age in the general population. We think, however, that the unclear validity of DSM-IV diagnostic criteria for this condition can lead to reduced prevalence rates by underestimation of the prevalence of adult ADHD.

Cited by 1,321 publications

References 56 publications

Dopamine Transporter (SLC6A3) Genotype Impacts Neurophysiological Correlates of Cognitive Response Control in an Adult Sample of Patients with ADHD

Dopamine Transporter (SLC6A3) Genotype Impacts Neurophysiological Correlates of Cognitive Response Control in an Adult Sample of Patients with ADHD

An international clinical study of ability and disability in ADHD using the WHO-ICF framework

Inter-hemispherical asymmetry in default-mode functional connectivity and BAIAP2 gene are associated with anger expression in ADHD adults

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