Prevalence and correlates of apathy and irritability in Alzheimer's disease

Migliorelli, R.; Starkstein, S.; Manes, Facundo; Tesón, A.; Petracca, Gustavo; Chemerinski, Erán; Sabe, Liliana; Leiguarda, R

doi:10.1016/0006-3223(95)94588-n

Cited by 11 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Possible biases in reports by patients and caregivers should also be considered. Several authors found that patients tend to underrate depressive symptoms [22,23], whereas caregivers may have difficulties distinguishing symptoms of dementia from those due to depression [22]. Both depression and burden in caregivers may also influence depression ratings of patients [24].…”

Section: Assessment Of Depression In Admentioning

confidence: 99%

See 1 more Smart Citation

Phenomenology of Depression in Alzheimer’s Disease

Novais

Starkstein

2015

JAD

View full text Add to dashboard Cite

Depression is among the most frequent psychiatric comorbid conditions in dementia. There is no strong consensus as to what criteria should be used to diagnose depression in AD. This is at least partially explained by the overlap between symptoms of depression and symptoms of AD. Recent studies using latent class analysis provided clarification to this diagnostic dilemma. All nine DSM-IV symptoms of major depression were found to characterize a class with a high chance (96% ) of having a clinical diagnosis of major depression, and symptoms of anxiety were also frequent. Other psychiatric symptoms may also be included under the construct of depression in AD, since both apathy and anxiety are among the most frequent comorbid conditions for major depression in AD. Subtypes of depression should also be validated in this condition. For instance, increased awareness of cognitive and functional deficits is significantly associated with dysthymia but not with major depression, suggesting that different depressive syndromes in AD may have different etiology.

show abstract

Section: Assessment Of Depression In Admentioning

confidence: 99%

“…Migliorelli et al [67] found a significant association between anosognosia and dysthymia, but not with major depression [23]. Starkstein et al [68] reported a valid diagnostic formulation for anosognosia in AD.…”

Section: Psychiatric Syndromes Associated With Depression In Admentioning

confidence: 99%

Phenomenology of Depression in Alzheimer’s Disease

Novais

Starkstein

2015

JAD

View full text Add to dashboard Cite

show abstract

“…There is a high incidence of co‐morbid depression in patients with AD [13, 14], and accumulating evidence shows that this can have profound effects on both the long‐term functioning of AD patients and the well‐being of their caregivers [15]. Its treatment represents a further challenge in the management of AD, since antidepressant medications will often be co‐administered with drugs for the treatment of AD symptoms [16, 17].…”

Section: Introductionmentioning

confidence: 99%

Concurrent administration of donepezil HCl and sertraline HCl in healthy volunteers: assessment of pharmacokinetic changes and safety following single and multiple oral doses

Nagy¹,

Kumar

Perdomo

et al. 2004

Brit J Clinical Pharma

View full text Add to dashboard Cite

AimThis study evaluated the safety and pharmacokinetics (PK) of donepezil HCl and sertraline HCl when administered separately and in combination. MethodsThis was a randomized, open-label, three-period crossover study. In consecutive dosing periods separated by washout periods of ≥ 3 weeks, healthy volunteers received either oral donepezil HCI 5 mg once daily for 15 days, oral sertraline HCl 50 mg once daily for 5 days followed by 10 days of once-daily sertraline HCl 100 mg, or the simultaneous administration of oral donepezil HCl and sertraline HCl. Plasma donepezil and sertraline concentrations were determined by high performance liquid chromatography/mass spectrometry. Safety was evaluated by physical and laboratory evaluations and the monitoring of adverse events (AEs).

show abstract

“…Migliorelli and coworkers demonstrated that major and minor depressions have different correlates among patients with AD [21]. These authors reported that major depression usually begins before the onset of dementia; it is associated with poor perfusion in specific brain areas (as assessed with single photon emission computed tomography) [22]; it is associated with more severe anosognosia than patients with minor depression [21]; and has a significantly longer duration than minor depression [23]. On the other hand, minor depression most often begins after the onset of cognitive decline; it is most frequent in the early stages of dementia, and is related to better awareness and less cognitive impairment than major depression.…”

Section: Subtypes Of Depression In Admentioning

confidence: 99%

The diagnosis of depression in Alzheimer’s disease: review of the current literature

Brockman¹,

Jayawardena²,

Starkstein³

2011

Neuropsychiatry

View full text Add to dashboard Cite

Depression is among the most common psychiatric disorders in Alzheimer's disease (AD). Nevertheless, given the overlap between the symptoms of depression and the symptoms of dementia, diagnosing depression is still problematic. Several depression rating scales have been validated for use in AD. Both the Hamilton Depression Rating Scale and the Montgomery-Asberg Depression Rating Scale have been used for screening purposes, to measure the severity of depression, and for assessing response to treatment. The recommendation to diagnose depression in AD is by using structured psychiatric interviews, such as the Structured Clinical Diagnostic Interview for DSM-IV or the Mini International Neuropsychiatric Interview. Based on information obtained from the structured interviews, depression is diagnosed using DSM-IV criteria. Consensus groups suggested specific changes to the diagnostic criteria to account for the overlap of symptoms between depression and dementia, and recent studies validated the DSM-IV criteria for major depression for use in AD.

show abstract

Prevalence and correlates of apathy and irritability in Alzheimer's disease

Cited by 11 publications

References 0 publications

Phenomenology of Depression in Alzheimer’s Disease

Phenomenology of Depression in Alzheimer’s Disease

Concurrent administration of donepezil HCl and sertraline HCl in healthy volunteers: assessment of pharmacokinetic changes and safety following single and multiple oral doses

The diagnosis of depression in Alzheimer’s disease: review of the current literature

Contact Info

Product

Resources

About