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SUMMARY Seven patients with Parkinson's disease and severe motor fluctuations were studied with event-related potentials, reaction and movement times and neuropsychological tests while in "off' and "on" phases. While there was a significant decrement in the P300 latency of the event-related potentials and in the duration ofmovement time in the "on" phase, no significant differences between on and off phases were observed in reaction time and neuropsychological tasks.

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