The Clinical Neuropsychiatry of Stroke, 2nd edn

Starkstein, S.

doi:10.1136/jnnp.2006.093278

Cited by 4 publications

(2 citation statements)

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“…Recently, several studies have paid solicitous attention to the risk factors of PSD, pertaining to functional and cognitive impairment, 5 lesion location, 6 gender, 7 and social support 2 . However, the mechanisms underlying PSD have not been fully explored.…”

Section: Introductionmentioning

confidence: 99%

Comparison of poststroke depression between acute ischemic and hemorrhagic stroke patients

Zeng

Cheng

et al. 2020

Int J Geriat Psychiatry

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Objectives Depression is the most common mental complication in stroke survivors with about one‐third of patients suffering from poststroke depression (PSD). This was the first prospective study aimed to compare the prevalence of PSD and its symptoms between two cohorts of patients with acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH). Methods Both AIS and ICH patients were simultaneously enrolled in the study. Depression symptoms were measured using the 17‐item Hamilton Depression Rating Scale (HAMD‐17) after a 1‐month follow‐up. Patients were diagnosed with PSD according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition and the HAMD‐17 (HAMD scores >7). Results The prevalence of PSD (42.3%) in the ICH group was significantly higher than that (22.9%) in the AIS group (p < 0.001). After adjustment for conventional confounding factors, the odds ratio of PSD was 2.65 (95% CI, 1.34–5.24, p = 0.005) for ICH compared to AIS. Depressive symptoms consisting of anxiety, loss of interest, insomnia, and fatigue were more frequent in patients with ICH than in AIS patients. Conclusions PSD was more prevalent, and the risk was over twofold higher in patients with ICH than AIS.

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Section: Introductionmentioning

confidence: 99%

Comparison of poststroke depression between acute ischemic and hemorrhagic stroke patients

Zeng

Cheng

et al. 2020

Int J Geriat Psychiatry

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“…[ 3 4 5 6 ] Depression after stroke, though recognized for more than a century, had never received the attention that has been devoted to other stroke complications, such as motor impairment, language problems, or cognitive deficits. [ 7 ] PSD not only leads to poor involvement in rehabilitation and delays functional recovery but results in limited social activity and increased disability. [ 8 9 ] Moreover, 12.3–73.2% of stroke survivors suffer from concurrent depression and anxiety which further delays recovery from stroke.…”

Section: Introductionmentioning

confidence: 99%

Depression impedes neuroplasticity and quality of life after stroke

Chaturvedi

Tiwari

Singh

et al. 2020

J Family Med Prim Care

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Background and Purpose: Depression following a stroke/poststroke depression (PSD) has been newly recognized as one of the most common complications after stroke. PSD may affect neuroplasticity and quality of life. The purpose of present study was to find out effects of depression on functional recovery, quality of life and neuroplasticity in patients with acute stroke. Methods: A total of 76 cases were recruited for the study and out of which 44 were available for the analysis after six months. Patients were divided into three groups according to severity of depression: Group A (without depression), Group B (mild-to-moderate depression), and Group C (severe depression) on the basis of Patient Health Questionnaire-9 (PHQ-9) scale scores. All patients were assessed for depression by PHQ-9, and for quality of life by Stroke Specific Quality of Life (SSQOL) scale. Neuroplasticity was assessed by measuring levels of serum brain-derived neurotrophic factor. Results: Quality of life was observed to be significantly affected by depression ( P ≤ 0.05). The most commonly affected characteristics were energy, family roles, mobility, self-care, social roles, upper extremity function, and work productivity. Serum BDNF levels were also affected significantly by depression ( P ≤ 0.05). Conclusion: PSD is a serious complication, affecting quality of life and neuroplasticity (BDNF) in patients. Decreased neuroplasticity further may affect functional improvement.

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