Prevalence and Correlates of Depressive Symptoms Within 6 Months After First-Time Mild Traumatic Brain Injury

Roy, Durga; Ghosh, Anjik; Yan, Hui; Leoutsakos, Jeannie‐Marie; Rao, Vani; Peters, Matthew E.; Meter, Timothy E. Van; Sair, Haris I.; Falk, Hayley; Korley, Frederick K.; Bechtold, Kathleen T.

doi:10.1176/appi.neuropsych.21080207

Cited by 7 publications

(4 citation statements)

References 66 publications

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“…The categories of sex, family history of migraine, depression, and contact/non-contact sport all appeared to be significant factors in determining mood and anxiety symptom burden post-injury in this study. As stated by previous research, athletes recovering from mTBI are more likely to have depression symptoms compared to healthy controls [21]. There is a prospective study that details a prediction model for major depressive episodes following mTBI [22].…”

Section: Discussionmentioning

confidence: 98%

Anxiety and Mood Disruption in Collegiate Athletes Acutely Following Mild Traumatic Brain Injury

Zhang,

Martyna,

Cornwell

et al. 2024

Diagnostics

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Objective: To report the symptom burden of anxiety and mood-related indicators following mTBI in collegiate student-athletes. Study Design: Retrospective cohort study of varsity collegiate athletes. Setting: University sports medicine at a tertiary care center. Patients: Division I college varsity athletes diagnosed with mTBI at a single institution between 2016 and 2019. Independent Variables: Pre- and post-injury. Main Outcome Measures: Comparisons between baseline testing and post-mTBI symptom scale assessments were made to determine changes in scores at the individual and group levels. The primary outcome was the prevalence of post-mTBI symptoms from within 72 h of injury through return to play. Associations with sport, sex, age, and return-to-play time were included. Results: Compared to baseline, mood and anxiety symptom scores were significantly higher acutely following mTBI (2.1 ± 3.3 vs. 14.3 ± 12.2; p < 0.001). A family history of migraine was significantly associated with higher mood and anxiety symptom scores (20.0 ± 14.9 with history vs. 13.3 ± 11.3 without history; p = 0.042). Mood and anxiety symptom scores were highly correlated with non-mood and anxiety symptom scores for all athletes, including the subgroup with prolonged symptoms (r = 0.769; p < 0.001). Conclusions: Symptoms of anxiety or mood disruption are common during the acute period post-injury in varsity college athletes. Risk factors for higher symptom reports immediately following mTBI and for prolonged symptoms (>10 days) included female sex, those with a family history of migraine, and those with an overall higher symptom burden post-injury.

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Section: Discussionmentioning

confidence: 98%

Anxiety and Mood Disruption in Collegiate Athletes Acutely Following Mild Traumatic Brain Injury

Zhang,

Martyna,

Cornwell

et al. 2024

Diagnostics

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“…Additionally, depression post-TBI is associated with reduced quality of life (Bombardier et al, 2010; Lin et al, 2010). Factors such as TBI severity (Ouellet et al, 2018; van der Horn et al, 2013) and demographics (e.g., age: Hart et al, 2011; Levin et al, 2005; Passler et al, 2022; race: D. Roy et al, 2022; Seel et al, 2003) may influence associations between mTBI and depression or suicidality; however, given a lack of large data sets with heterogeneous samples, it is difficult to draw firm conclusions from the extant literature.…”

Section: Post-tbi Depressionmentioning

confidence: 99%

Harmonizing federal interagency traumatic brain injury research data to examine depression and suicide-related outcomes.

O'Neil,

Krushnic,

Clauss

et al. 2024

Rehabilitation Psychology

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Objective: This proof-of-concept study was conducted to establish the feasibility of compiling Federal Interagency Traumatic Brain Injury Research (FITBIR) data pertaining to depression and suicide risk, with the secondary goal of improving understanding regarding these outcomes. FITBIR is a national repository of participant-level traumatic brain injury (TBI) data designed to address methodological limitations (e.g., small sample size, heterogeneity of injuries). Method: FITBIR studies with TBI severity and measures related to depression and suicidal ideation were identified. Data were harmonized across relevant studies and grouped to identify "probable depression" and suicidal ideation, resulting in a large, combined sample. Rates of probable depression and suicidal ideation were described across the available studies, considering the influence of demographic and/or injury-related factors on outcomes. Results: Cross-sectional studies This article was published Online First March 21,

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“…Indeed, there is evidence that the presence of behavioral neuropsychiatric symptoms after head injury is associated with worse rehabilitation and long-term outcomes. 11,12 Being able to systematically identify and swiftly treat head injury-related behavioral symptoms has the potential to contribute to improved rehabilitation and long-term outcomes.…”

mentioning

confidence: 99%

“…We hypothesize this domain-based approach may also have utility when looking at noncognitive, neuropsychiatric symptoms following head injury regardless of cognitive status. Indeed, there is evidence that the presence of behavioral neuropsychiatric symptoms after head injury is associated with worse rehabilitation and long-term outcomes 11,12. Being able to systematically identify and swiftly treat head injury-related behavioral symptoms has the potential to contribute to improved rehabilitation and long-term outcomes.…”

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confidence: 99%

Associations of Prior Head Injury With Mild Behavioral Impairment Domains

Richey

Young

Bray

et al. 2024

Journal of Head Trauma Rehabilitation

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Objective: This study investigated associations of prior head injury and number of prior head injuries with mild behavioral impairment (MBI) domains. Setting: The Atherosclerosis Risk in Communities (ARIC) Study. Participants: A total of 2534 community-dwelling older adults who took part in the ARIC Neurocognitive Study stage 2 examination were included. Design: This was a prospective cohort study. Head injury was defined using self-reported and International Classification of Diseases, Ninth Revision (ICD-9) code data. MBI domains were defined using the Neuropsychiatric Inventory Questionnaire (NPI-Q) via an established algorithm mapping noncognitive neuropsychiatric symptoms to the 6 domains of decreased motivation, affective dysregulation, impulse dyscontrol, social inappropriateness, and abnormal perception/thought content. Main Measures: The primary outcome was the presence of impairment in MBI domains. Results: Participants were a mean age of 76 years, with a median time from first head injury to NPI-Q administration of 32 years. The age-adjusted prevalence of symptoms in any 1+ MBI domains was significantly higher among individuals with versus without prior head injury (31.3% vs 26.0%, P = .027). In adjusted models, a history of 2+ head injuries, but not 1 prior head injury, was associated with increased odds of impairment in affective dysregulation and impulse dyscontrol domains, compared with no history of head injury (odds ratio [OR] = 1.83, 95% CI = 1.13-2.98, and OR = 1.74, 95% CI = 1.08-2.78, respectively). Prior head injury was not associated with symptoms in MBI domains of decreased motivation, social inappropriateness, and abnormal perception/thought content (all P > .05). Conclusion: Prior head injury in older adults was associated with greater MBI domain symptoms, specifically affective dysregulation and impulse dyscontrol. Our results suggest that the construct of MBI can be used to systematically examine the noncognitive neuropsychiatric sequelae of head injury; further studies are needed to examine whether the systematic identification and rapid treatment of neuropsychiatric symptoms after head injury is associated with improved outcomes.

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Prevalence and Correlates of Depressive Symptoms Within 6 Months After First-Time Mild Traumatic Brain Injury

Cited by 7 publications

References 66 publications

Anxiety and Mood Disruption in Collegiate Athletes Acutely Following Mild Traumatic Brain Injury

Anxiety and Mood Disruption in Collegiate Athletes Acutely Following Mild Traumatic Brain Injury

Harmonizing federal interagency traumatic brain injury research data to examine depression and suicide-related outcomes.

Associations of Prior Head Injury With Mild Behavioral Impairment Domains

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