Prevalence and correlates of mixed-handedness in schizophrenia

Cannon, Mary; Byrne, Majella; Cassidy, Brendan; Larkin, Conall; Horgan, Richard; Sheppard, Noel; O’Callaghan, Eadbhard

doi:10.1016/0165-1781(95)02730-0

Cited by 58 publications

(38 citation statements)

References 34 publications

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“…In the only comparable study of young patients, Lishman and McMeekan (1976) found 11% mixed handedness in psychotic patients (mean ages25 years). Several reports indicate higher rates of mixed handedness in adult patients ranging from 36 to 43% (Green et al, 1989;Nelson et al, 1993;Cannon et al, 1995); however, these studies employed different handedness inventories and applied less restrictive classifications of mixed hand preference. When a similar classification was applied to the current dataset, the rate of mixed handedness in patients corresponded with these estimates.…”

Section: Discussionmentioning

confidence: 99%

Is lateral bias anomalous in early-onset schizophrenia? Selected comparisons with normal populations

Collinson

Phillips²,

James

et al. 2004

Psychiatry Research

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The aim of this study was to investigate lateral bias in patients with early-onset schizophrenia. Hand, eye, and foot preferences and relative hand skill were examined in early-onset patients (ns44) and matched controls (ns39), and were compared with population estimates. Patients demonstrated a significant excess in mixed handedness (20.5% vs. 8.5%) relative to population estimates and reduced relative hand skill on a pegboard task compared with controls. Left eye preference was significantly less common in schizophrenic patients relative to population estimates. Crossed eye-hand and eye-foot preferences were not significantly increased in the patient group as a whole but were present, respectively, in four of nine and five of nine mixed-handed patients but in none of five mixed-handed controls. These findings are consistent with the view that lateralisation is anomalous in schizophrenia early in the course of illness.

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Section: Discussionmentioning

confidence: 99%

Is lateral bias anomalous in early-onset schizophrenia? Selected comparisons with normal populations

Collinson

Phillips²,

James

et al. 2004

Psychiatry Research

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“…Schizophrenia is associated with reduced functional and structural laterality. There is robust support for mixed handedness in schizophrenia (Cannon et al, 1995;Crow et al, 1996;DeLisi et al, 2002) and in schizotypes (Chapman and Chapman, 1987;Claridge et al, 1998;Kim et al, 1992;Richardson, 1994) rather than pure left-handedness (Shaw et al, 2001). Mixed handedness is associated with decreased cerebral lateralization, schizotypy, and enhanced creativity (Claridge and Broks, 1984).…”

Section: Introductionmentioning

confidence: 98%

Verbal creativity and schizotypal personality in relation to prefrontal hemispheric laterality: A behavioral and near-infrared optical imaging study

Folley

Park

2005

Schizophrenia Research

179

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Although anecdotal and correlational results have suggested a reliable relationship between creativity and psychosis, few studies have examined this relationship using empirical methods. In addition, little is known about the neural substrates of creative thinking. We investigated the creative thinking process in relation to schizotypal personality, schizophrenia and prefrontal hemispheric laterality using behavioral and near-infrared optical spectroscopy (NIRS) methods. Schizophrenic, psychometrically ascertained schizotypal, and healthy control subjects (all right-handed) participated in a novel "alternate uses" task designed to assess divergent thinking (DT) ability. The DT task required subjects to generate "uses" for conventional and ambiguous objects. Prefrontal activity was measured using NIRS while subjects were engaged in DT vs. a cognitive control task in a subset of the subjects. Behavioral data indicated that schizotypes had enhanced DT ability compared with schizophrenic and control subjects, who showed similar performance overall. NIRS data showed that DT was associated with bilateral prefrontal cortex (PFC) activation, but the right PFC particularly contributed to the enhanced creative thinking in psychometric schizotypes compared with the other two groups. Thus, creative thinking seems to robustly recruit bilateral PFC, but it is the right PFC that is preferentially activated in schizotypes in relation to their enhanced DT.

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“…Crow 31 suggested that this abnormal brain asymmetry reflects disturbances in the expression of the gene(s) that controls the development of brain asymmetry, and that genetically determined anomalies in development are responsible for morphological abnormalities of the planum temporale 29 ' 30 , and the anomalous hand dominance frequently observed in schizophrenia 32 . Following this line of argument, one would expect abnormalities in brain asymmetry to be particularly evident in familial schizophrenics in whom genetic mechanisms can be assumed to predominate.…”

Section: Early 'Lesion' Hypothesismentioning

confidence: 99%

Imaging as a tool in exploring the neurodevelopment and genetics of schizophrenia

Frangou

Murray

1996

British Medical Bulletin

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Neuroimaging has enabled us to address questions about the timing and origin of brain abnormalities in schizophrenia. First episode and longitudinal computed tomography (CT) and magnetic resonance imaging (MRI) studies of schizophrenic patients have shown that the brain abnormalities are present at onset of psychosis and are non-progressive. Such findings support the idea that schizophrenia is a developmental rather than a degenerative condition. Furthermore, the presence of ventriculomegaly and diminished hemispheric asymmetry in familial schizophrenics and in those of their relatives who appear to be transmitting the disorder, implies involvement of the genes controlling neurodevelopment. However, genetic factors do not fully account for the development of schizophrenia; early environmental insults such as obstetric complications are also important and may interact with genetic predisposition. Brain development continues postnatally and profound maturational events also occur in adolescence and early adulthood. Magnetic resonance spectroscopy (MRS) studies allow the investigation of the developmental biochemistry of the living brain and are being used to explore the role of maturational brain events in determining the onset of psychosis. Neuroimaging methods allow for the safe in vivo study of brain development, structure and function, and provide the means to investigate hypotheses regarding the aetiology and pathophysiology of schizophrenia. In this article, we review neuroimaging studies of schizophrenia, and focus particularly on findings that provide insights into the genetic and neurodevelopmental origins of the disorder.

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Prevalence and correlates of mixed-handedness in schizophrenia

Cited by 58 publications

References 34 publications

Is lateral bias anomalous in early-onset schizophrenia? Selected comparisons with normal populations

Is lateral bias anomalous in early-onset schizophrenia? Selected comparisons with normal populations

Verbal creativity and schizotypal personality in relation to prefrontal hemispheric laterality: A behavioral and near-infrared optical imaging study

Imaging as a tool in exploring the neurodevelopment and genetics of schizophrenia

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