Prevalence and correlates of suicidal thoughts in patients with neuropsychiatric lupus

Hajduk, Adam; Nowicka-Sauer, Katarzyna; Smoleńska, Żaneta; Czuszyńska, Zenobia; Zdrojewski, Zbigniew

doi:10.1177/0961203315603136

Cited by 17 publications

(14 citation statements)

References 37 publications

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“…Our finding emphasized the role of anxiety, which, according to the literature review, was a mostly ignored phenomenon in studies on SLE 39,40 despite the fact that anxiety symptoms seem to be more severe than depression in SLE sufferers and coexist with suicidal ideation. 11,41,42 Consistent with other authors, we suggest that many patients may not meet the diagnostic criteria of a particular anxiety disorder; 39 however, they may suffer from an increased level of anxiety and routine assessment of anxiety in patients with SLE seems vital. 8,39,40…”

Section: Discussionsupporting

confidence: 86%

Illness perception is significantly determined by depression and anxiety in systemic lupus erythematosus

Nowicka-Sauer

Hajduk

Kujawska-Danecka

et al. 2018

Lupus

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Objectives Illness perception is a cognitive representation influencing physical and psychological functioning and adherence in patients with rheumatic disease. Studies exploring illness perception in systemic lupus erythematosus (SLE) are still scarce and none of them have investigated factors determining illness perception. We aimed to assess illness perception and to identify psychological, clinical and sociodemographic factors that might influence illness perception in SLE. Methods The study involved 80 patients with SLE (87.5% women, mean age 41.56 years). The Brief Illness Perception Questionnaire, State Trait Anxiety Inventory, Beck Depression Inventory, Pittsburgh Sleep Quality Index, Visual Analogue Scale-Pain and Fatigue Severity Scale were used. Clinical and sociodemographic data were collected via structured interview and medical files review. Results Illness perception was significantly positively correlated with anxiety, depression, sleep quality, fatigue and pain while it was not related to age, education, steroid treatment, disease duration and activity (SLEDAI) or organ damage (SLICC/ACR). Regression analysis revealed that state anxiety and depression explained 43% of illness perception variance. Cluster analysis identified three patient groups among which the middle-aged group had the most negative illness perception, the highest levels of anxiety, depression, pain and fatigue, and the poorest sleep quality. Conclusions The study has proved a significant relationship between negative illness perception and anxiety and depression. Patients reporting fatigue, poor sleep and pain might have special needs in terms of psychological intervention focused on negative illness perception and distress symptoms. Multidisciplinary care in managing SLE seems to be of great importance.

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Section: Discussionsupporting

confidence: 86%

Illness perception is significantly determined by depression and anxiety in systemic lupus erythematosus

Nowicka-Sauer

Hajduk

Kujawska-Danecka

et al. 2018

Lupus

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“…This results in direct and indirect costs related to disease development, with the indirect costs often being higher [17]. The literature also presents the data confirming that patients with SLE often have suicidal tendencies as compared to the general population [18]. This may be associated with a direct impact of this disease on the Central nervous system (the neuropsychiatric lupus); however, this may also be significantly affected by the patient awareness of the impact of the disease on their common daily and occupational routine activities, inability to find a permanent job, and problems in their families caused by this disease.…”

Section: Discussionmentioning

confidence: 92%

Living with Systemic Lupus Erythematosus: A Profile of Young Female Patients

Macejová

Gecková

Husárová

et al. 2020

IJERPH

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The aim is to describe a profile of systemic lupus erythematosus (SLE) patient (socio-demographic data, course of disease, health status, and health care utilization, SLE impact on their life, SLE awareness) and to explore the association of patient’s perspective with clinical indicators. Adult patients diagnosed by SLE were recruited in outpatient clinics (n = 76, 88% female, data collected in 2012–2016, Slovakia). The association of patients’ perspective (SLE status, health complaints during remission, SLE impact, hospitalizations) with clinical activity (European Consensus Lupus Activity Measurement Index—ECLAM) and inflammatory marker (erythrocyte sedimentation rate—ESR) was assessed by t-test for independent variables and one-way ANOVA. Almost 17.9% of patients reported relapse. During remission, they mostly suffered fatigue and pain. Nearly all patients were on chronic pharmacological treatment. Most of the patients assessed SLE impact on their life as restrictive (56.9%) or very restrictive (23.1%). The most frequent source of information was their physician, and 67.2% reported that they have sufficient information about the disease and its treatment. Only the association of SLE status and hospitalization with clinical activity (ECLAM) and inflammatory marker (ESR) were confirmed. With recent improvements in diagnostics and therapy options, the prognosis for patients with SLE has improved. Nevertheless, the impact of this disease on all areas of a patient’s life is extensive.

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“…45 Se ha evidenciado también que las manifestaciones neuropsiquiatrícas ocurren tanto en niños como en adultos. 46 En esta muestra no utilizamos escalas de evaluación para el LES del tipo Lupus Erythematous Activity Index (SLEDAI) para medir actividad y establecer relación de casos con afecciones neuropsiquiátricas; por lo tanto, no es posible hacer inferencias al respecto. 47 De acuerdo con los hallazgos clínicos observamos en los niños mayor actividad de la enfermedad y que en ellos se emplean más fár-macos inmunosupresores en comparación con los adultos; esto coincide con otros reportes.…”

Section: Discussionunclassified

Características clínicas y comorbilidades de pacientes con lupus eritematoso sistémico en niños y adultos

Alvarado¹,

Saiz²,

Cruz³

2018

Acta Pediatr Mex

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Este artículo debe citarse comoCoronado-Alvarado CD, Gámez-Saiz IL, SoteloCruz N. Características clínicas y comorbilidades de pacientes con lupus eritematoso sistémico en niños y adultos. Acta Pediatr Mex. 2018;39(1):1-12. Recibido: 20 de octubre del 2016 Aceptado: 4 de abril del 2017Resumen INTRODUCCIÓN: el lupus eritematoso sistémico es una enfermedad autoinmune crónica; se presenta mayormente en mujeres en etapa reproductiva y es menos frecuente en niños.OBJETIVO: comparar las manifestaciones clínicas, comorbilidades y farmacoterapia en niños y adultos con lupus eritematoso sistémico (LES). MATERIAL Y MÉTODOS:se seleccionaron 127 expedientes clínicos de pacientes con diagnóstico de LES; 36 menores de edad de un hospital pediátrico (grupo A) y 91 adultos de un hospital general (grupo B). Recolectamos información respecto a las manifestaciones clínicas al diagnóstico en los niños y adultos, así como las comorbilidades relacionadas y mortalidad, atendiendo los criterios de la American College of Rheumatology, también del tipo de medicamentos empleados. Estadísticas utilizadas: cálculo de frecuencias, porcentajes, la prueba de ji cuadrada, prueba exacta de Fisher, razón de momios e intervalos de confianza.RESULTADOS: en niños predominaron: eritema malar (p = < 0.01), vasculitis (p < 0.01), fotosensibilidad (p < 0.01), síndrome nefrítico (p < 0.01), alteraciones leucocitarias (p < 0.01), derrame pleural, anemia, derrame pericárdico, sepsis y hepatopatía; además, el número de medicamentos empleados fue mayor. En adultos predominaron: artralgia (p < 0.01), pancitopenia (p = 0.025), alopecia (p < 0.01), sinovitis (p = 0.044) y falla renal crónica (p = 0.04). Los fármacos usados en el grupo A fueron: hidroxicloroquina (p < 0.01), glucocorticoides (p = 0.14) y micofenolato (p = 0.28), la mortalidad en niños fue de 25% y en 91 adultos ocurrió en 5 (0.05%).CONCLUSIONES: las manifestaciones clínicas en niños muestran mayor lesión cutánea inicial y vasculitis, daño renal, cardiovascular, pulmonar e infecciones; en los adultos predominan afecciones articulares y falla renal crónica. Los niños reciben mayor número de fármacos y su mortalidad es mayor.PALABRAS CLAVE: lupus eritematoso sistémico, manifestaciones clínicas, niños, adultos.

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Prevalence and correlates of suicidal thoughts in patients with neuropsychiatric lupus

Abstract: Suicidal thoughts are common in patients with NPSLE. Neuropsychiatric manifestation per se, depression, anxiety and patients' subjective complaints can be risk factors for suicidal ideation. Screening for suicidal thoughts is vital in routine care of SLE patients.

Cited by 17 publications

References 37 publications

Illness perception is significantly determined by depression and anxiety in systemic lupus erythematosus

Illness perception is significantly determined by depression and anxiety in systemic lupus erythematosus

Living with Systemic Lupus Erythematosus: A Profile of Young Female Patients

Características clínicas y comorbilidades de pacientes con lupus eritematoso sistémico en niños y adultos

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