Prevalence and determinants of carotid atherosclerosis in a general population.

Prati, Patrizio; Vanuzzo, Diego; Casaroli, M.; Achangwa, Chiara; Biasi, Fiorella; Feruglio, G A; Touboul, Pierre‐Jean

doi:10.1161/01.str.23.12.1705

Cited by 259 publications

(194 citation statements)

References 49 publications

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“…Jungquist et al 14 found stenosis of 60% or greater in 4.5% of men aged 69 examined in his study. Prati et al 12 reported a very low prevalence of stenotic plaque (>40%) in subjects aged 80 years or older (7.1% in men and 12.1% in women). These data, derived from cross-sectional studies, do not allow speculation as to the natural history of atherosclerotic disease in elderly subjects.…”

Section: Discussionmentioning

confidence: 99%

Carotid plaque, aging, and risk factors. A study of 457 subjects.

Fabris

Zanocchi

et al. 1994

Stroke

155

103

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Background and Purpose The aim of this study was to assess the prevalence of extracranial carotid artery atherosclerosis and its relation to principal cardiovascular risk factors at different ages in a sample of the general population.Methods B-mode ultrasonography was used to investigate the carotid district in 457 subjects (231 men and 226 women; mean age, 55.4±18.7 years; range, 18 to 97 years) in the metropolitan area. The ultrasonographic findings were then related to risk factors.Results Carotid plaques were found in 178 subjects (38.9%). The prevalence of atherosclerosis, number of plaques, and severity of stenosis were observed to increase with age. Age (P<.0Q01), cigarette smoking (P<.0001), male sex (P<.001), total cholesterol (P<.05), and, inversely, the ratio of high-density lipoprotein cholesterol to total cholesterol (P<.05) were found to be independently associated with

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Section: Discussionmentioning

confidence: 99%

Carotid plaque, aging, and risk factors. A study of 457 subjects.

Fabris

Zanocchi

et al. 1994

Stroke

155

103

View full text Add to dashboard Cite

show abstract

“…11,12 any vascular bed (Table 1). 6,9,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Progression of carotid atherosclerosis also is influenced by concomitant risk factors (Table 2). [31][32][33][34][35][36][37] Carotid atherosclerosis is commonly found in association with coronary and peripheral atherosclerosis.…”

Section: Methodsmentioning

confidence: 99%

Surrogate Markers for Cardiovascular Disease

2004

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“…27 This can be explained by the fact that at older age, BMI is not such an important determinant of common CIMT. Several studies [37][38][39][40][41] showed that in middle-aged and elderly subjects, only age, hypertension, dyslipidemia and current smoking were important independent determinants of increased common CIMT. In these studies, the association between BMI and CIMT was probably mediated through a number of these risk factors and lost its significance when adjusted for them.…”

Section: Change In Body Mass Index and Increased Cimt A Oren Et Almentioning

confidence: 99%

Change in body mass index from adolescence to young adulthood and increased carotid intima-media thickness at 28 years of age: The Atherosclerosis Risk in Young Adults study

et al. 2003

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Obesity has become a major health problem in Western societies by increasing the risk of atherosclerosis and cardiovascular disease. Although data on tracking of body mass index (BMI) are available, little is known about the impact of weight change over time on the development of vascular damage. OBJECTIVE: To evaluate the relationship between adolescent BMI as well as change in BMI from adolescence into young adulthood and cardiovascular risk, as estimated by common carotid intima-media thickness (CIMT). DESIGN: Cohort study. SUBJECTS: A total of 750 healthy young adults, aged 27-30 y, who attended secondary school in Utrecht, the Netherlands. MEASUREMENTS: Data on adolescent weight, height, blood pressure and puberty stage were available from the original school health records of the Municipal Health Service. At young adulthood, a questionnaire on cardiovascular risk factors was completed and fasting blood sample was drawn and common CIMT was measured. RESULTS: One standard deviation (s.d.) increase in adolescent BMI was associated with 2.3 mm [95% confidence interval (CI): 1.3; 3.3] increase in mean common CIMT in young adults after adjustment for gender, adolescent age, adolescent blood pressure, puberty stage and lumen diameter. Further adjustment for adult cardiovascular risk factors did not change the relationship (linear regression coefficient ¼ 2.1 mm/s.d.; 95% CI: 1.0; 3.1). Adjustment for adult BMI attenuated the association (linear regression coefficient ¼ 0.9 mm/s.d.; 95% CI: À0.3; 2.2) as the majority of overweight and obese adolescents remained overweight or became obese young adults. Subjects who remained in the upper BMI distribution from adolescence into young adulthood had a significantly higher common CIMT compared to those who showed relative weight loss over time (mean difference 14.7 mm; Po0.001). These latter showed similar CIMT values as individuals with constant low BMI. CONCLUSION: Adolescent BMI predicts cardiovascular risk, as estimated by common CIMT in young adulthood. Individuals who experience the largest increase in BMI and those who remain overweight over time have the thickest common CIMT.

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Prevalence and determinants of carotid atherosclerosis in a general population.

Cited by 259 publications

References 49 publications

Carotid plaque, aging, and risk factors. A study of 457 subjects.

Carotid plaque, aging, and risk factors. A study of 457 subjects.

Surrogate Markers for Cardiovascular Disease

Change in body mass index from adolescence to young adulthood and increased carotid intima-media thickness at 28 years of age: The Atherosclerosis Risk in Young Adults study

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