Prevalence and Genotype Distribution of HPV among Women Attending a Cervical Cancer Screening Mobile Unit in Lampang, Thailand

Abstract

A growing body of literature is evidence that identifying subtypes of high-risk human papillomavirus (HR-HPV) has impacted on various steps of cervical cancer prevention.Thus, it is mandatory to determine the background prevalence and distribution of HPV subtypes for designing and implementing area-specific management. The present study was conducted to evaluate prevalence and distribution of HPV subtypes among women aged 30-70 years living in Lampang, an area with a high incidence of cervical cancer, through use of a mobile screening unit. Of 2,000 women recruited in this study, 108 (5.40%, 95%CI: 4.45-6.48) were found to have HR-HPV infection. Risk was significantly correlated with age and number of partners. Singly or in combination, the most common genotype was HPV 52 (17.6%), followed by HPV 16 (14.81%), HPV 58 (13.89%), HPV 33 (11.11%), HPV 51 (11.11%), and HPV 56 (9.26%). HPV 18 was found in only 5.6% of cases. Together, HPV 16/18 were noted in approximately 20.4% of cases. Eighteen(16.67%) women were positive with multiple subtypes of HR-HPV. Co-infection most frequently involved HPV 16 or HPV 58. These findings have obvious implications for vaccine policy.

Overview: Epidemiological Characteristics of HPV in Uzbekistan.

“…The highest prevalence (occurrence) of the HPV virus was found in the age group of 30-34 years -31.5%. This contrasts with published data around the world, which indicates that all the same, the majority of cases of HPV detection occur in the age of 25 years [9,10,13,16]. This shows the country feature of the manifestation of the epidemiology of HPV in Uzbekistan.…”

National and Subnational Population-Based Incidence of Cancer in Thailand: Assessing Cancers with the Highest Burdens

“…Prevalence of HPV by population is 6% in the north, 8.7% in Bangkok, 14.1% in the northeast and 3% in the south [ 51 , 52 , 53 , 54 ]. Although HPV16 and HPV18 are the most common types, HPV52 and HPV58 also have high prevalence in the Thai population [ 51 , 54 , 55 , 56 , 57 ]. Information over time is limited on other risk factors for cervical cancer, however reports indicate that age at first intercourse has dropped sharply in the past two decades.…”

Mobile Screening Units for the Early Detection of Cancer: A Systematic Review

“…All 10 multiphasic programs reported screening for cervical cancer. Notably, many of the cervical cancer screening studies were in low-resource settings in Brazil, Peru, South Africa, India, Thailand, and Taiwan (15,20,21,(24)(25)(26)(27). The studies report diverse outcomes of detection of precancerous cervical lesions and invasive cancer, as described in Table 3.…”