Prevalence and genotype distribution of human papillomavirus in 961,029 screening tests in southeastern China (Zhejiang Province) between 2011 and 2015

Chen, Xiao; Xu, Haidong; Xu, Wanwan; Zhang, Wenjie; Liu, Jinwei; Wu, Qing; Zhao, Xiaofeng; Tang, Jian

doi:10.1038/s41598-017-13299-y

Cited by 35 publications

(38 citation statements)

References 29 publications

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“…A large amount of clinical data has shown that high‐risk HPV infections are significantly age‐specific . High‐risk HPV infections have a very high positive rate, approaching 30%, in young women, especially those aged <25 years, but most are transient infections.…”

Section: Discussionmentioning

confidence: 99%

The distribution and prevalence of human papillomavirus in women in mainland China

Song

et al. 2019

Cancer

145

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We conducted a systematic review of the epidemiology of high-risk human papillomavirus (HPV) infections in mainland Chinese women to provide a general profile for the application and subsequent effectiveness evaluation of HPV vaccines. The PubMed, Web of Science, Medline (Ovid), China National Knowledge Infrastructure, and Wanfang databases were used for the literature search. The epidemiological studies published from January 2000 to June 2018 on high-risk HPVs in mainland Chinese women were investigated to systematically evaluate their epidemiological status. A total of 198 eligible studies were included. The results of metaanalysis showed that the overall infection rate of high-risk HPVs in mainland Chinese women was 19.0% (95% confidence interval [CI], 17.1%-20.9%), and the top 5 subtypes with the highest infection rates were 16, 52, 58, 53, and 18. The overall infection rates of cervical intraepithelial neoplasia I (CINI), CINII+, and cervical cancer patients were 59.6% (95% CI, 52.7%-66.4%), 84.8% (95% CI, 81.2%-88.5%), and 89.9% (95% CI, 86.6%-93.1%), respectively. The high-risk HPV infections and common subtypes in women of various ages in various regions were different, and the high-risk HPVs and subtypes in cervical cancer patients in various regions were also different. In conclusion, we systematically analyzed the HPV infections in women who live on the Chinese mainland. The epidemiology of high-risk HPVs in mainland Chinese women is basically consistent with that for the rest of the world. The HPV vaccines currently licensed in China could cover the major prevalent high-risk HPV subtypes in China, providing a basis for the development of cervical cancer screening strategy and the vaccine implementation in China.

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Section: Discussionmentioning

confidence: 99%

The distribution and prevalence of human papillomavirus in women in mainland China

Song

et al. 2019

Cancer

145

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“…Geographical differences in HPV genotype distribution may affect the effectiveness of the HPV vaccine in different populations and different age groups. 9 When evaluating the effects of current prophylactic vaccines and developing new vaccines, the limited cross-protection among HPV types 10 and the heterogeneity in HPV type-specific distributions in different regions and different populations [11][12][13] should be considered. However, existing HPV vaccines have not fully considered the heterogeneity of HPV genotypes distribution in individual regions.…”

mentioning

confidence: 99%

Cervical human papillomavirus among women in Guangdong, China 2008‐2017: Implication for screening and vaccination

Luo

Sun

et al. 2019

Journal of Medical Virology

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Our study aimed to analyze genotype‐specific, age‐specific prevalence, and year‐on‐year trend of cervical human papillomavirus (HPV) detection among women in Guangdong, China 2008 to 2017. A total of 199 963 women attending the gynecological department and 11 999 women attending the medical examination center at Guangdong Women and Children Hospital were included. Prevalent HPV detection significantly differed between these two groups of women (20.16% vs 17.25%; P < .001). HPV genotypes of these two populations have a large overlap, with HPV52, 16, 58, CP8304, and 53 being the dominant subtypes among gynecological outpatients and HPV52, CP8304, 58, 53, and 16 among women receiving physical examinations. The distribution of prevalent HPV detection showed a bimodal pattern across age groups among these two populations. However, prevalent HPV detection among these two populations exhibited different trends from 2008 to 2017. Our study demonstrated that prevalent HPV detection among women in Guangdong is associated with age and different from that among women from other regions of China. Our study may provide valuable data to inform cervical cancer screening and HPV vaccination programs for women in this province.

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“…These studies demonstrate a HR-HPV infection rate ranging approximately 10-15% in Chinese women, which is in agreement with our finding. However, the method we used in the present study is simpler and less laborious compared with those used in previous investigations [22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

“…Globally, HR-HPV prevalence varies from continent to continent [21]. In China, for the survey of HR-HPV prevalence, different methods have been used [22][23][24][25]. Wu et al employed the Hybrid Capture 2 Assay (Qiagen, Hilden, Germany) for the detection of HR-HPV of 13 pooled types (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68) in a total of 4215 women aged 17-54 years from 5 different geographical areas of China and discovered that HR-HPV prevalence was 12.4% [22].…”

Section: Discussionmentioning

confidence: 99%

“…Using the same method as Wu et al [22], Zhao et al found that 15.2% of 1274 women from a region in North China were positive for HR-HPV [23]. Chen et al employed a HPV Genotyping Kit (Yaneng Biotechnology Limited Corp., Shenzhen, China) for a total of 961,029 HPV tests for women aged 16 to 83 years from Southeastern China and revealed a HR-HPV infection rate of 16.61% [24]. Jing et al applied a mass spectrometric assay for HPV-DNA testing in 78,355 women aged 18 to 75 years from South China and reported a <7.3% HR-HPV prevalence rate [25].…”

Section: Discussionmentioning

confidence: 99%

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Application of the Cobas 4800 System for the Detection of High-Risk Human Papillomavirus in 5650 Asymptomatic Women

Wang

Meng

et al. 2020

BioMed Research International

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High-risk papillomavirus (HR-HPV) testing combined with cytology improves the detection of cervical lesions and increases length of screening intervals. For a population-based HR-HPV survey, testing automation is in great need. The Cobas 4800 HPV Test System is a fully automated assay that can simultaneously detect HPV16, HPV18, and other 12 pooled HR-HPV genotypes. This system has been employed for HR-HPV screening in a number of countries; however, such application in a large population in China has not been documented. In this study, we employed the Cobas 4800 HPV Test System to detect HR-HPV in cervical cytology specimens collected from a total of 5650 asymptomatic women from a region of South China. We reported the following: (1) the prevalence of the 14 genotypes of HR-HPV was 12.96%; (2) for those with HR-HPV infection, 2.25% were positive for HPV16, 0.50% for HPV18, 9.15% for pooled 12 HPV types, and 1.06% for multiple HPV infection; and (3) there was no significant difference in the HR-HPV prevalence among different age groups. HPV16 and HPV18 have been shown to be the predominant HPV types found in cervical cancer patients in some regions in China, indicating that a fully automated assay like the Cobas 4800 HPV Test System is especially valuable for population-based HR-HPV screening in these regions as this assay can concurrently detect HPV16 and HPV18.

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Prevalence and genotype distribution of human papillomavirus in 961,029 screening tests in southeastern China (Zhejiang Province) between 2011 and 2015

Cited by 35 publications

References 29 publications

The distribution and prevalence of human papillomavirus in women in mainland China

The distribution and prevalence of human papillomavirus in women in mainland China

Cervical human papillomavirus among women in Guangdong, China 2008‐2017: Implication for screening and vaccination

Application of the Cobas 4800 System for the Detection of High-Risk Human Papillomavirus in 5650 Asymptomatic Women

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