Prevalence and genotype distribution of HPV infection among women in Ningbo, China

Hong, Hang; He, Tianfeng; Ni, Hongxia; Shu, Zhang; Xu, Guozhang

doi:10.1016/j.ijgo.2015.04.027

Cited by 25 publications

(27 citation statements)

References 22 publications

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“…However, these issues are outside the scope of this epidemiological study. Further comparative analysis showed that HPV16, 52, and 58 are the three most dominant high-risk HPV strains in five Chinese reports, although the order of prevalence rates from high to low varied widely and other genotype distributions also differed regionally in China [21][22][23][24][25]. Other data from India, Northern Ireland, the USA and integrated data varied except for HPV16, which remained a dominant strain worldwide [26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 98%

“…Both the quadrivalent and bivalent vaccines protect against HPV types 16 and 18, which cause 70% of cervical cancers; the quadrivalent vaccine also protects against HPV types 6 and 11, which cause 90% of genital wart cases [33]. Although it is difficult to map the HPV genotype distribution and prevalence, large amounts of data indicate that HPV genotype distribution varies largely across regions [21][22][23][24][25][26][27][28][29][30]. Thus, regional HPV surveillance is essential for effective vaccination and HPV-related cancer control and prevention.…”

Section: Discussionmentioning

confidence: 99%

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Genotype distribution characteristics of high-risk human papillomaviruses in women from Shanghai, China

Gu¹,

Yi²,

Xu³

et al. 2015

Epidemiol. Infect.

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High-risk human papillomaviruses (HPVs) are highly prevalent worldwide, and HPV genotype distribution varies regionally. Molecular surveys of HPVs are important for effective HPV control and prevention. Fifteen high-risk HPV strains (16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68) and six low-risk HPV strains (HPV6, 11, 42, 43, 44, CP8304) were detected by cervical cytology from 10 501 subjects. High-risk HPVs, low-risk HPVs, and both high- and low-risk HPVs were detected in 14·5%, 2·8%, and 2·4% of cases, respectively. Of 1782 subjects with high-risk HPV infection, 75·5%, 18·1%, and 6·4% were infected with one, two, and ⩾3 strains of high-risk HPVs, respectively. HPV52, HPV16, and HPV58 were the top three most dominant high-risk HPV genotypes in our population with positivity rates of 23·0%, 17·7% and 16·9%, respectively. Multiple infection was common, with significantly higher co-infection rates of HPV58/HPV33 (12·9%) and HPV58/HPV52 (11·3%). Further data comparisons showed that HPV genotype distribution varied markedly between domestic and international regions. In conclusion, a monolithic vaccination strategy is obviously impractical, and regional HPV surveillance is essential to optimize current HPV control and prevention.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Genotype distribution characteristics of high-risk human papillomaviruses in women from Shanghai, China

Gu¹,

Yi²,

Xu³

et al. 2015

Epidemiol. Infect.

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“…These last interventions are most important, particularly in HIV-positive women, where the HPV-vaccination yet must be shown to be efficacious in HIV-infected individuals (20) particularly in the group with a CD4 count inferior to 500 cell/mm 3 . Secondly, another interesting aspect about vaccines issues from our study: the currently marketed vaccines do not provide total coverage against HPV infections; in fact, for the great variability of HPV circulating genotypes, not all most frequently circulating genotypes are included in 2-or 4-valent HPV vaccines (22)(23)(24) such as genotypes 31, more frequent in HIV-positive women, and 52/58, more frequent in healthy women. This variability may be particularly dangerous in HIV-positive women where there is an increased risk of H-SIL and invasive cervical cancer related also to other HPV-genotypes different from HPV-16 and -18.…”

Section: Group 1 (Hiv Negative) Group 2 (Hiv Positive) --------------mentioning

confidence: 97%

Prevalence of HPV infection among HIV‑positive and HIV‑negative women in Central/Eastern Italy: Strategies of prevention

et al. 2017

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Abstract. The present cross-sectional-study aimed to determine the prevalence of human papillomavirus (HPV)-genotypes among human immunodeficiency virus (HIV)-positive and -negative women in Central/Eastern Italy, and to identify the optimal strategies for effective HPV-prevention in each group. A representative sample of HIV-negative (150/200) and -positive (50/200) women, who underwent cervico-vaginal-swabbing. Swabs were analysed for a cytological screening and for a HPV-DNA-genotyping-test. A total of 66/200 swabs resulted HPV-positive. The overall HPV-prevalence was 33% with a higher prevalence in the HIV-positive-group (48%) compared with the HIV-negative-group (28%). The most frequent genotypes were: 16, 31, 52, 58, 66, 73 and 89. Furthermore, the prevalence of specific genotypes was different in each group. The results of the present study indicate that HIV infection appears to be an independent risk factor for HPV-infection. In addition, HPV-infection is more common and more likely to persist in HIV-positive compared with in HIV-negative women. The optimal way to counteract HPV infection is through primary prevention. The stage of immunity (cluster of differentiation 4-level) at the time of the HPV-screening is one of the most important parameters for detection of susceptibility to HPV-infection and to evaluate the response to the HPV-vaccine in HIV-positive women. It may be used to determine the sub-group of HIV-positive women that are more prone to HPV-infections or that exhibit a partial response to the HPV-vaccine. At present, a novel type of vaccine with 9-genotypes is available and in the near future, it may serve an essential role in the prevention of HPV infections.

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“…In China, a pooled analysis of 17 population-based studies, including 30,207 females, identified the HPV prevalence to be 17.7% (50). Furthermore, a province-wide study was conducted in Ningbo province which identified 185 of 1,373 females aged between 22 and 64 years (13.5%) as HPV-positive and the prevalence rates were 13.8, 8.8 and 7.9% in Shenzhen, Xinjiang and Chaozhou, respectively (51–54). The papillomavirus family is heterogeneous and highly species-specific.…”

Section: Ovarian Carcinogenesis and Microorganismsmentioning

confidence: 99%

Microbial infection, inflammation and epithelial ovarian cancer

et al. 2017

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Ovarian cancer is the most common, and life-threatening, type of female gynecological cancer. The etiology of ovarian cancer remains unclear, and there are currently no effective screening or treatment methods for the disease. Microbial infection serves a marked function in inducing carcinogenesis. A number of studies have identified pelvic inflammatory disease as a risk factor for epithelial ovarian cancer. Thus, it is hypothesized that microbial infection may contribute to ovarian cancer. In the present review, the microorganisms that have been identified to be associated with ovarian cancer and the underlying molecular mechanisms involved are discussed. Infection-induced chronic inflammation is considered an important process for carcinogenesis, cancer progression and metastasis. Therefore, the pathological process and associated inflammatory factors are reviewed in the present paper.

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Prevalence and genotype distribution of HPV infection among women in Ningbo, China

Abstract: In Ningbo, many women with cervical cytologic abnormalities have HPV infection. Vaccines targeting HPV52 and HPV58 in conjunction with HPV16 and HPV18 are required for the prevention and treatment of cervical lesions in Chinese women.

Cited by 25 publications

References 22 publications

Genotype distribution characteristics of high-risk human papillomaviruses in women from Shanghai, China

Genotype distribution characteristics of high-risk human papillomaviruses in women from Shanghai, China

Prevalence of HPV infection among HIV‑positive and HIV‑negative women in Central/Eastern Italy: Strategies of prevention

Microbial infection, inflammation and epithelial ovarian cancer

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