Prevalence and genotype identification of human papillomavirus in women undergoing voluntary cervical cancer screening in Molise, Central Italy

Ripabelli, Giancarlo; Grasso, G.; Riccio, Ilenia Del; Tamburro, Manuela; Sammarco, Michela Lucia

doi:10.1016/j.canep.2009.12.010

Cited by 23 publications

(20 citation statements)

References 39 publications

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“…Confortini found no significant relationship between HPV infection and the use of hormonal contraception, but showed a protective role of condom use in women who use it every time, or in most cases [13]. Similar results were obtained by other authors exploring the relationship between HPV infection and the use of hormonal contraception [34,36,41,42]. In our study did not show connection of HPV infection with the use of hormonal contraception and condoms.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Risk factors for cervical cancer among young women

Wężowska¹,

Giedrys-Kalemba²,

Szymaniak³

et al. 2012

Open Medicine

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Section: Discussionsupporting

confidence: 88%

“…Similarly, the two fold increase in risk of HPV infection in the case of nicotine addiction has been reported by Confortini among women aged 18 to 24 [13]. Also, other studies have linked smoking with HPV infection [33,34]. In our study, the relationship between cigarette smoking and HPV infection was not confirmed.…”

Section: Discussioncontrasting

confidence: 57%

Risk factors for cervical cancer among young women

Wężowska¹,

Giedrys-Kalemba²,

Szymaniak³

et al. 2012

Open Medicine

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“…HPV 16 is the most prevalent type all over the world with the exception of Eastern Africa, Japan, and Taiwan, where HPV 52 was considered to be the most common type [24,28]. The HPV 16 prevalence for HPV-positive women from this study (31.9% of HPV-positive women) was similar to previous reports from Europe, Canada, and the USA [24,31].…”

Section: Discussionsupporting

confidence: 78%

Type-Specific Human Papillomavirus Prevalence in Iranian Women with Normal Cervical Cytology: The Impact of Current HPV Vaccines

et al. 2017

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Objective: Human papillomavirus (HPV) vaccination is currently not included in the national vaccination program in Iran. Regional data on the distribution of HPV types in women are important as they can predict the impact of currently available vaccines and help health policy makers to consider all the possibilities with regard to HPV vaccination. Methods: A total of 1,218 Iranian women with normal cervical cytology were included in this study. The presence of the HPV genome was investigated in all specimens by PCR assay, and all HPV-positive samples were genotyped. Results: Totally, HPV was detected in 88 samples (7.2%). According to different geographical regions, the HPV prevalence varied: the highest HPV prevalence was observed in the North (11.7%) and the lowest in the Center (4.5%) of Iran, and this difference reached a statistically significant level (p < 0.05). In this study, the most frequent HPV types were HPV 16, 18, 66, and 11, representing 63.8% of all HPV infections. Conclusion: Based on this study, it is estimated that HPV vaccines could have a great impact on the prevention of cervical cancer in Iran. This study highlights the necessity of introducing educational programs in high schools, robust screening programs, and vaccination in Iran.

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“…With the exception of Eastern Africa, China, Japan and Taiwan [21-23], HPV 16 is the most prevalent type in all parts of the world. Our study showed that HPV 53 was the second most common genotype (16% in the whole series), which is similar to previous Italian [24,25] and Spanish [17,19,26] studies, however, HPV 53 is not a frequent genotype in other Mediterranean countries, such as Greece and Turkey [27,28].…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus genotype distribution in Madrid and correlation with cytological data

et al. 2011

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BackgroundCervical cancer is the second most common cancer in women worldwide. Infection with certain human papillomavirus (HPV) genotypes is the most important risk factor associated with cervical cancer. This study analysed the distribution of type-specific HPV infection among women with normal and abnormal cytology, to assess the potential benefit of prophylaxis with anti-HPV vaccines.MethodsCervical samples of 2,461 women (median age 34 years; range 15-75) from the centre of Spain were tested for HPV DNA. These included 1,656 samples with normal cytology (NC), 336 with atypical squamous cells of undetermined significance (ASCUS), 387 low-grade squamous intraepithelial lesions (LSILs), and 82 high-grade squamous intraepithelial lesions (HSILs). HPV detection and genotyping were performed by PCR using 5'-biotinylated MY09/11 consensus primers, and reverse dot blot hybridisation.ResultsHPV infection was detected in 1,062 women (43.2%). Out of these, 334 (31%) samples had normal cytology and 728 (69%) showed some cytological abnormality: 284 (27%) ASCUS, 365 (34%) LSILs, and 79 (8%) HSILs. The most common genotype found was HPV 16 (28%) with the following distribution: 21% in NC samples, 31% in ASCUS, 26% in LSILs, and 51% in HSILs. HPV 53 was the second most frequent (16%): 16% in NC, 16% in ASCUS, 19% in LSILs, and 5% in HSILs. The third genotype was HPV 31 (12%): 10% in NC, 11% in ASCUS, 14% in LSILs, and 11% in HSILs. Co-infections were found in 366 samples (34%). In 25%, 36%, 45% and 20% of samples with NC, ASCUS, LSIL and HSIL, respectively, more than one genotype was found.ConclusionsHPV 16 was the most frequent genotype in our area, followed by HPV 53 and 31, with a low prevalence of HPV 18 even in HSILs. The frequency of genotypes 16, 52 and 58 increased significantly from ASCUS to HSILs. Although a vaccine against HPV 16 and 18 could theoretically prevent approximately 50% of HSILs, genotypes not covered by the vaccine are frequent in our population. Knowledge of the epidemiological distribution is necessary to predict the effect of vaccines on incidence of infection and evaluate cross-protection from current vaccines against infection with other types.

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Prevalence and genotype identification of human papillomavirus in women undergoing voluntary cervical cancer screening in Molise, Central Italy

Cited by 23 publications

References 39 publications

Risk factors for cervical cancer among young women

Risk factors for cervical cancer among young women

Type-Specific Human Papillomavirus Prevalence in Iranian Women with Normal Cervical Cytology: The Impact of Current HPV Vaccines

Human papillomavirus genotype distribution in Madrid and correlation with cytological data

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