Prevalence and human papillomavirus (HPV) genotype distribution in Suzhou, China

Wang, Tianyu; Li, Lin; Deng, Jingjing; Yao, Yu; Wu, Qianlan; Gong, Tao; Zhu, Jingjing; Zhang, Zhuoyu; Zhang, Jun

doi:10.1080/21645515.2023.2241309

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…Other studies carried out in different geographical areas, mainly in China, have shown similar results. HPV51 has been reported in several studies to be one of the most common circulating genotypes in women, similar to HPV53 and HPV68 [ 52 , 53 , 54 , 55 , 56 ]. As for HPV66, Zheng et al also identified it among the significantly prevalent hrHPV in Chinese women [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

“…A volume of 200 µL of oral pellets resuspended in PBS was used to extract DNA using the QIAamp Mini Kit (Qiagen, Hilden, Germany). HPV-DNA detection was carried out using INNOLiPA ® HPV Genotyping Extra II (Fujirebio, Tokyo, Japan), which identifies 23 genotypes classified as hrHPV or probable hrHPV (HPV16, 18,31,33,35,39,45,51,52,56,58,59,67,68,26,53,66,70,73,82) and 9 types classified as lrHPV (HPV6, 11,40,42,43,44,54,61,62,81,83,89). In this technique, a 65 bp fragment of the L1 gene, generated by an SPF10 PCR, is subjected to a reverse-dot blot hybridization assay.…”

Section: Samples Processing and Hpv-dna Extraction Detection And Geno...mentioning

confidence: 99%

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Orogenital Human Papillomavirus Infection and Vaccines: A Survey of High- and Low-Risk Genotypes Not Included in Vaccines

Buttà,

Serra,

Panzarella

et al. 2023

Vaccines

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Knowledge of human papillomavirus transmission from the genital tract to the oral mucosa remains unsatisfactory, with poor and often inconsistent literature results. The increase in HPV-associated oral malignancies prompts further analysis of the simultaneous detection of the virus in the two anatomical areas and on the identification of genotypes to be included in future vaccines. Therefore, in this retrospective study, we evaluated orogenital HPV concurrence, hrHPV, lrHPV and type-concordance in 337 samples, as well as the prevalence of the most common genotypes not included in HPV vaccines. Concurrence was found in 12.5% (31/248) of cases, hr-concordance in 61.3% (19/31) and lr-concordance in 12.9% (4/31). Finally, type-concordance was found in 32.3% (10/31) of concurrent infections. Regarding the identification of non-vaccine genotypes, the significantly prevalent genotypes in the anogenital area were HPV66 (12.6%, p < 0.0001), HPV53 (11.1%, p < 0.0001), HPV51 (8.7%, p < 0.0001), HPV42 (8.2%, p < 0.0001) and HPV68 (5.6%, p = 0.0034) in women and HPV66 (14.6%, p = 0.0058), HPV42 (12.2%, p = 0.0428), HPV51 (12.2%, p = 0.0428), HPV53 (12.2%, p = 0.0428), HPV70 (12.2%, p = 0.0428) and HPV73 (12.2%, p = 0.0428) in men. Considering the results of our study, we recommend including the high-risk genotypes HPV51, HPV68, HPV53 and HPV66 in future HPV vaccine formulations.

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Section: Discussionmentioning

confidence: 99%

Section: Samples Processing and Hpv-dna Extraction Detection And Geno...mentioning

confidence: 99%

Orogenital Human Papillomavirus Infection and Vaccines: A Survey of High- and Low-Risk Genotypes Not Included in Vaccines

Buttà,

Serra,

Panzarella

et al. 2023

Vaccines

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Prevalence and genotype distribution of HPV combined with cervical pathological results in women from Sichuan, China: A cross‐sectional study based on post‐vaccination period 2019 to 2023

Mo,

Ye,

et al. 2024

Cancer Medicine

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BackgroundHuman papillomavirus (HPV) screening and vaccination exert efficacy in controlling the progression of cervical cancer. Thus, examinations into HPV prevalence, age‐stratified specificity, genotype distribution, and their correlation with pathological outcomes can furnish robust evidence for customizing high‐quality population screening and management.MethodsA cohort of 17,923 women attending clinics in the Jintang area, Sichuan, from January 2019 through August 2023 were enrolled in the study. Genotyping of HPV was conducted using real‐time polymerase chain reaction (RT‐PCR). The epidemiology and the relationship between HPV infection and histologic/cytologic abnormalities were subjected to analysis.ResultsHPV infection was identified in 4387 women. The outpatient group exhibited a significantly higher HPV infection rate compared to the healthy examination group (26.5% vs. 17.5%, p < 0.05). The distribution of infection rates across different age groups exhibited a U‐shaped pattern, with the highest infection rate in the group ≤20 years of age, succeeded by those >60 years of age. The 31–40 age group demonstrated the lowest prevalence of infection, but upon infection, its prevalence of the precancerous lesion CIN2‐3 reached a maximum of 29.0%, constituting a novel finding. The most prevalent genotype was HPV52, followed by HPV16, 58, 53, 68, and 18. In the cytologic and histologic abnormalities group, the most common types were HPV52, 16, and 58. HPV16 predominantly appeared in high‐grade intraepithelial neoplasia and carcinoma in situ, constituting over 60% of cases. While HPV type 52 was not individually detected in cervical cancer cases. And some other non‐vaccine‐covered HPV subtypes also showed high prevalence in Sichuan. The single infection rates of NH9‐HPV (high‐risk HPV subtypes covered by the non‐nine‐valent vaccine) in CIN2‐3 and cervical cancer patients were 6.5% and 2.6%, respectively. Among them, HPV51, HPV53, HPV59, and HPV35 exhibited a significant preponderance, which even higher than HPV45 and HPV31 covered by the nine‐valent vaccine types. And in NL9‐HPV (low‐risk HPV subtypes covered by the non‐nine‐valent vaccine), HPV42 accounted for the highest percentage in CIN2‐3. A similar decreasing trend was observed in annual infection rates in the healthy examination population and in the 31–40 and 51–60 age groups, while the ≤20 age group showed an increase. Regarding type‐specificity, HPV16 and HPV58 exhibited the most rapid declines.ConclusionThis study furnishes the latest insights into the characteristics of HPV infection rate, age distribution, and genotype prevalence in Sichuan.

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Opportunities and challenges for human papillomavirus vaccination in China

Zhao,

et al. 2024

Human Vaccines & Immunotherapeutics

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Prevalence and human papillomavirus (HPV) genotype distribution in Suzhou, China

Cited by 7 publications

References 33 publications

Orogenital Human Papillomavirus Infection and Vaccines: A Survey of High- and Low-Risk Genotypes Not Included in Vaccines

Orogenital Human Papillomavirus Infection and Vaccines: A Survey of High- and Low-Risk Genotypes Not Included in Vaccines

Prevalence and genotype distribution of HPV combined with cervical pathological results in women from Sichuan, China: A cross‐sectional study based on post‐vaccination period 2019 to 2023

Opportunities and challenges for human papillomavirus vaccination in China

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