Prevalence and impact of cannabis use disorders in adolescents with early onset first episode psychosis

Schimmelmann, Benno G.; Conus, Philippe; Cotton, Sue; Kupferschmid, Stephan; McGorry, Patrick D.; Lambert, Martin

doi:10.1016/j.eurpsy.2011.03.001

Cited by 69 publications

(63 citation statements)

References 33 publications

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“…SUD patients look younger at onset of psychiatric symptoms (Modestin et al, 2001), more frequently male and smokers (Cantor-Graae et al, 2001), unmarried (Farrelly et al, 2007;Wobrock et al, 2007;Mazzoncini et al, 2010) and unemployed (Compton et al, 2009;Barrigón et al, 2010;Schimmelmann et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…(Cantwell et al, 1999;Veen et al, 2004;Henquet et al, 2005;Mauri et al, 2006;Koskinen et al, 2010;Mazzoncini et al, 2010;Barrigón et al, 2010). Several studies on schizophrenia have reported that patients with SUD have worse premorbid social functioning (Sevy et al, 2010;Mazzoncini et al, 2010;Compton et al, 2011;Schimmelmann et al, 2011), more severe symptoms at onset (Gearon and Bellack, 2000;Dawe et al, 2011), lower compliance and worse treatment response, thus more inappropriate use of mental health services, (Lambert et al, 2005;de Haan et al, 2007;Schimmelmann et al, 2011) with higher mental health costs (Bartels et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Does substance use disorder affect clinical expression in first-hospitalization patients with schizophrenia? Analysis of a prospective cohort

Picci

Versino

Oliva

et al. 2013

Psychiatry Research

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Introduction. Although several papers reported a wide range of negative outcomes among patients with both schizophrenia and SUD, only a few studies evaluated the impact of SUD on psychopathology and thus on the length of first-hospitalization. Objectives.To compare clinical expression of first-episode of schizophrenia between inpatients with and without SUD, giving close attention to the length of stay.Methods. 130 inpatients at first-episode of schizophrenia were assigned to SUD or not SUD group depending on SUD diagnosis and were assessed through BPRS at admission, during hospitalization and at discharge. Cross-sectional and longitudinal statistical analysis were performed to investigate differences between groups and also a linear regression was used to evaluate relationship between length of stay and BPRS scores.Results. During the hospitalization there was a more marked improvement of BPRS total score in patients without SUD with a lower length of hospitalization (P<0.001). BPRS score during hospitalization was predictor of higher length of stay.Discussion. The higher severity of psychopathology during the hospitalization suggest possible overlaps of substance induced and withdrawal symptoms. Conversely, higher levels of conceptual disorganization during the whole period of hospitalization also support a more severe and pharmacho-resistant expression of schizophrenia among SUD patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Does substance use disorder affect clinical expression in first-hospitalization patients with schizophrenia? Analysis of a prospective cohort

Picci

Versino

Oliva

et al. 2013

Psychiatry Research

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“…21,25 In the CAFEPS study, adolescent cannabis users were older at baseline and had higher positive and negative syndrome scale (PANSS) positive scores and lower PANSS negative, PANSS general and PANSS total scores than non-users.…”

mentioning

confidence: 99%

Cannabis and mental illness in adolescents: a review

Paruk

Burns

2015

South African Family Practice

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“…The increased risk appears to be dose-related and may be greater in those with a family history of schizophrenia. Cannabis is arguably the most serious comorbidity with schizophrenia because of its widespread use among young people with mental illness (Schimmelmann et al, 2012). Cannabis use has a well-recognised role in triggering onset and exacerbations of schizophrenia (Gururajan et al, 2012;Stefanis et al, 2014) and is associated with a worse outcome and reduced efficacy of treatment (Gupta et al, 2013).…”

Section: Psychosis and Substance Usementioning

confidence: 99%

Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders

Galletly

Castle

Dark

et al. 2016

Aust N Z J Psychiatry

665

672

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Objectives: This guideline provides recommendations for the clinical management of schizophrenia and related disorders for health professionals working in Australia and New Zealand. It aims to encourage all clinicians to adopt best practice principles. The recommendations represent the consensus of a group of Australian and New Zealand experts in the management of schizophrenia and related disorders. This guideline includes the management of ultra-high risk syndromes, first-episode psychoses and prolonged psychoses, including psychoses associated with substance use. It takes a holistic approach, addressing all aspects of the care of people with schizophrenia and related disorders, not only correct diagnosis and symptom relief but also optimal recovery of social function. Methods:The writing group planned the scope and individual members drafted sections according to their area of interest and expertise, with reference to existing systematic reviews and informal literature reviews undertaken for this guideline. In addition, experts in specific areas contributed to the relevant sections. All members of the writing group reviewed the entire document. The writing group also considered relevant international clinical practice guidelines. Evidence-based recommendations were formulated when the writing group judged that there was sufficient evidence on a topic. Where evidence was weak or lacking, consensus-based recommendations were formulated. Consensus-based recommendations are based on the consensus of a group of experts in the field and are informed by their agreement as a group, according to their collective clinical and research knowledge and experience. Key considerations were selected and reviewed by the writing group. To encourage wide community participation, the Royal Australian and New Zealand College of Psychiatrists invited review by its committees and members, an expert advisory committee and key stakeholders including professional bodies and special interest groups. RANZCP GuidelinesGalletly et al. 411 Australian & New Zealand Journal of Psychiatry, 50(5)Results: The clinical practice guideline for the management of schizophrenia and related disorders reflects an increasing emphasis on early intervention, physical health, psychosocial treatments, cultural considerations and improving vocational outcomes. The guideline uses a clinical staging model as a framework for recommendations regarding assessment, treatment and ongoing care. This guideline also refers its readers to selected published guidelines or statements directly relevant to Australian and New Zealand practice. Conclusions:This clinical practice guideline for the management of schizophrenia and related disorders aims to improve care for people with these disorders living in Australia and New Zealand. It advocates a respectful, collaborative approach; optimal evidence-based treatment; and consideration of the specific needs of those in adverse circumstances or facing additional challenges.

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Prevalence and impact of cannabis use disorders in adolescents with early onset first episode psychosis

Cited by 69 publications

References 33 publications

Does substance use disorder affect clinical expression in first-hospitalization patients with schizophrenia? Analysis of a prospective cohort

Does substance use disorder affect clinical expression in first-hospitalization patients with schizophrenia? Analysis of a prospective cohort

Cannabis and mental illness in adolescents: a review

Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders

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