Prevalence and in vitro antifungal susceptibility of cryptic species of the genus Aspergillus isolated in clinical samples

Vidal-Acuña, María Reyes; Ruiz, María Antonia Carmona; Torres, María José; Aznar, Javier

doi:10.1016/j.eimce.2018.07.017

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…In our study, A. quadrilineatus exhibited low MIC values for azoles and echinocandin agents. Similarly, in two other published reports by Salah et al and Vidal‐Acuna et al, 23,28 posaconazole and anidulafungin showed potent in vitro activity against A. quadrilineatus . Moreover, in agreement with the study conducted by Vidal‐Acuna et al, 28 we found that amphotericin B had high MIC value against A. quadrilineatus .…”

Section: Discussionsupporting

confidence: 62%

“…According to EORTC/MSG criteria, proven IFI is related to positive fungus in histology/culture of sterile tissue samples.In our study, A. quadrilineatus exhibited low MIC values for azoles and echinocandin agents. Similarly, in two other published reports by Salah et al and Vidal-Acuna et al,23,28 posaconazole and anidulafungin showed potent in vitro activity against A. quadrilineatus. With the appearance of fungal infections due to cryptic species and their possible resistance to routine antifungal agents, screening studies are highly recommended to evaluate the frequency of cryptic species, and more antifungal susceptibility data are needed before being recommended as first-line therapy against infections due to cryptic species in high-risk patients.All authors have made substantial contributions to the conception and acquisition of data, drafting of the article, and approval of the final version.…”

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confidence: 64%

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Central nervous system Aspergillus quadrilineatus infection in a COVID‐19 patient, a case report and literature review

Amirizad,

Ghazanfari,

Javidnia

et al. 2023

Clinical Laboratory Analysis

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BackgroundViral pneumonia such as COVID‐19‐associated aspergillosis could increase susceptibility to fungal super‐infections in critically ill patients.MethodsHere we report a pediatric case of Aspergillus quadrilineatus cerebral infection in a recently diagnosed COVID‐19‐positive patient underlying acute lymphocytic leukemia. Morphological, molecular methods, and sequencing were used to identify this emerging species.ResultsHistopathological examination showed a granulomatous necrotic area containing dichotomously branching septate hyphae indicating a presumptive Aspergillus structure. The species‐level identity of isolate growing on brain biopsy culture was confirmed by PCR sequencing of the β‐tubulin gene as A. quadrilineatus. Using the CLSI M38‐A3 broth microdilution methodology, the in vitro antifungal susceptibility testing demonstrated 0.032 μg/mL MIC for posaconazole, caspofungin, and anidulafungin and 8 μg/mL against amphotericin B. A combination of intravenous liposomal amphotericin B and caspofungin therapy for 8 days did not improve the patient's condition. The patient gradually continued to deteriorate and expired.ConclusionsThis is the first COVID‐19‐associated cerebral aspergillosis due to A. quadrilineatus in a pediatric patient with acute lymphocytic leukemia. However, comprehensive screening studies are highly recommended to evaluate its frequency and antifungal susceptibility profiles. Before being recommended as first‐line therapy in high‐risk patients, more antifungal susceptibility data are needed.

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Section: Discussionsupporting

confidence: 62%

supporting

confidence: 64%

Central nervous system Aspergillus quadrilineatus infection in a COVID‐19 patient, a case report and literature review

Amirizad,

Ghazanfari,

Javidnia

et al. 2023

Clinical Laboratory Analysis

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“…Among these fungi, Aspergillus was first described in 1729. 1,2 For over three centuries approximately 250 species have been recognized in the genus. 3,4 Some species of Aspergillus have negatively affected man in so many areas of life, both medically and commercially.…”

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confidence: 99%

Effects of Botanicals on Growth and Aflatoxin Production by Aspergillus flavus Infecting Maize

2021

TJNPR

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Fungi have been associated with man from ancient times. Among these fungi, Aspergillus was first described in 1729. 1,2 For over three centuries approximately 250 species have been recognized in the genus. 3,4 Some species of Aspergillus have negatively affected man in so many areas of life, both medically and commercially. Constant inhalation of spores of Aspergillus species had resulted in some predisposition of humans and other animals to Aspergillosis. Mechanism of toxin production by Aspergillus species in foods are still being studied as some Aspergillus species may also produce toxic compounds (Mycotoxins) which presents a serious health risk for both man and animals. 5,6 There are different types of mycotoxins identified, with some being harmful to man and animals, e.g. zearalenone, fuminosins, aflatoxins, ochratoxins, vomitoxins, etc. [7][8][9] Aflatoxin was discovered in 1960 in England where close to 100,000 turkey poults died from aflatoxinpoisoning after eating peanut meal contaminated with Aspergillus flavus. [10][11][12] The discovery led to a growing awareness of the potential hazards (aflatoxicosis) of these substances as contaminants of food and feed; causing illness and even death in humans and animal. 10 Maize (Zea mays L.), along with wheat (Triticuma estivum L.) and rice (Oryza sativa L.), are the primary staple food cereals in many countries. 13

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Aspergilli series Versicolores: importance of species identification in the clinical setting

Géry¹,

Séguin²,

Pécoulas³

et al. 2022

Critical Reviews in Microbiology

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Prevalence and in vitro antifungal susceptibility of cryptic species of the genus Aspergillus isolated in clinical samples

Cited by 3 publications

References 27 publications

Central nervous system Aspergillus quadrilineatus infection in a COVID‐19 patient, a case report and literature review

Central nervous system Aspergillus quadrilineatus infection in a COVID‐19 patient, a case report and literature review

Effects of Botanicals on Growth and Aflatoxin Production by Aspergillus flavus Infecting Maize

Aspergilli series Versicolores: importance of species identification in the clinical setting

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