Prevalence and incidence rates of mental syndromes after occupational exposure to polychlorinated biphenyls

Gaum, Petra Maria; Esser, André; Schettgen, Thomas; Gube, Monika; Kraus, Thomas; Lang, Jessica

doi:10.1016/j.ijheh.2014.04.001

Cited by 30 publications

(13 citation statements)

References 31 publications

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“…Conversely, rats exposed prenatally and lactationally to a higher dose of PCBs than used in the current study (10 mg/kg dam s.c. injection) did not demonstrate altered anxiety behavior when tested in a different arena, the elevated zero maze (Colciago et al, 2009). In humans with higher than average circulating PCBs, depressivity but not anxiety was increased (Gaum et al, 2014). In Inuit children, PCB 153 exposure, another more heavily chlorinated PCB than those used in the current study, was correlated with increased unhappiness and anxiety (Plusquellec et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Anxiety-like behaviors in adulthood are altered in male but not female rats exposed to low dosages of polychlorinated biphenyls in utero

Gillette

Reilly

Topper

et al. 2017

Hormones and Behavior

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Exposure to polychlorinated biphenyls (PCBs), a class of endocrine-disrupting chemicals, can result in altered reproductive behavior in adulthood, especially when exposure occurs during critical periods of brain sexual differentiation in the fetus. Whether PCBs alter other sexually dimorphic behaviors such as those involved in anxiety is poorly understood. To address this, pregnant rat dams were injected twice, on gestational days 16 and 18, with the weakly estrogenic PCB mixture Aroclor 1221 (A1221) at one of two low dosages (0.5 mg/kg or 1.0 mg/kg, hereafter 1.0 and 0.5), estradiol benzoate (EB; 50 μg/kg) as a positive estrogenic control, or the vehicle (3% DMSO in sesame oil). We also conducted a comprehensive assessment of developmental milestones of the F1 male and female offspring. There were no effects of treatment on sex ratio at birth and age at eye opening. Puberty, assessed by vaginal opening in females and preputial separation in males, was not affected in females but was advanced in males treated with A1221 (1.0). Males and females treated with A1221 (both dosages) were heavier in early adulthood relative to controls. The earliest manifestation of this effect developed in males prior to puberty and in females slightly later, during puberty. Anxiety-like behaviors were tested using the light:dark box and elevated plus maze tests in adulthood. In females, anxiety behaviors were unaffected by treatment. Males treated with A1221 (1.0) showed reduced indices of anxiety and increased activity in the light:dark box but not the elevated plus maze. EB failed to replicate the phenotype produced by A1221 for any of the developmental and behavioral endpoints. Collectively, these results indicate that PCBs increase body weight in both sexes, but their effects on anxiety-like behaviors are specific to males. Furthermore, differences between the results of A1221 and EB suggest that the PCBs are likely acting through mechanisms distinct from their estrogenic activity.

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Section: Discussionmentioning

confidence: 99%

Anxiety-like behaviors in adulthood are altered in male but not female rats exposed to low dosages of polychlorinated biphenyls in utero

Gillette

Reilly

Topper

et al. 2017

Hormones and Behavior

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“…Analysis including individuals with their plasma PCBs collected via bio-monitoring and the psychological syndromes assessed with a consistent screening method. Results showed greater PCB burdened individuals had greater depression but not anxiety syndrome [ 56 ].…”

Section: Influence Of Estrogenic Endocrine Disruptors Exposure On mentioning

confidence: 99%

Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders

et al. 2018

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The devastating growth in the worldwide frequency of neurocognitive disorders and its allied difficulties, such as decline in memory, spatial competency, and ability to focus, poses a significant psychological public health problem. Inhibitor of differentiation (ID) proteins are members of a family of helix-loop-helix (HLH) transcription factors. ID proteins have been demonstrated to be involved in neurodevelopmental and depressive diseases and, thus, may influence neurocognitive deficiencies due to environmental exposure. Previously, it has been demonstrated that environmental factors, such as estrogenic endocrine disruptors (EEDs), have played an essential role in the influence of various neurocognitive disorders such as Alzheimer’s, dementia, and Parkinson’s disease. Based on this increasing number of reports, we consider the impact of these environmental pollutants on ID proteins. Better understanding of how these ID proteins by which EED exposure can affect neurocognitive disorders in populations will prospectively deliver valuable information in the impediment and regulation of these diseases linked with environmental factor exposure.

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“…Mixed results have been reported: higher levels of heavily chlorinated PCBs that induce CYP2B in serum increased the incidence of depressive like symptoms in older adults [62], but not diagnoses of depression in young adults [63]. Different effects are even found among capacitor workers occupationally exposed to PCBs earlier in their life: in a German study, higher measures of DL and NDL congeners were associated with major increases in symptoms of depression but not anxiety [64], whereas in a US study, no associations were found [65]. Findings of increased depressive symptoms are also true in studies of exposure to other EDCs, especially pesticides [66].…”

Section: Effects Of Developmental Pcb Exposure On Social Behavior Andmentioning

confidence: 99%

Endocrine-disrupting actions of PCBs on brain development and social and reproductive behaviors

Bell

2014

Current Opinion in Pharmacology

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Polychlorinated biphenyls are among the most well-studied endocrine-disrupting chemicals (EDCs) for their neurobehavioral effects, especially neurodevelopment and cognitive performance. In addition, past research has demonstrated effects of PCBs on circulating hormones and associated changes in reproductive behaviors. This article will focus on recent advances that have been made in characterizing developmental PCB effects on reproductive function, broader social and affective behaviors, and the neuroendocrine mechanisms behind such changes. In general, PCBs seem to inhibit reproductive function by suppressing multiple aspects of the associated hypothalamic circuitry. Additionally, PCBs may also reduce motivation for social behaviors and induce depressive-like symptoms via overall reductions in dopaminergic and glutamatergic functions in the limbic system. However, more work with human-relevant exposure paradigms is needed to fully support these conclusions.

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Prevalence and incidence rates of mental syndromes after occupational exposure to polychlorinated biphenyls

Cited by 30 publications

References 31 publications

Anxiety-like behaviors in adulthood are altered in male but not female rats exposed to low dosages of polychlorinated biphenyls in utero

Anxiety-like behaviors in adulthood are altered in male but not female rats exposed to low dosages of polychlorinated biphenyls in utero

Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders

Endocrine-disrupting actions of PCBs on brain development and social and reproductive behaviors

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