Prevalence and manifestations of hepatitis C seropositivity in children in an endemic area

Lu, Sheng–Nan; Chen, Hui‐Chi; Tang, Chiu-Ming; Wu, Mei-Huei; Yu, Ming‐Lung; Chuang, Wan‐Long; Lu, Chih-Feng; Chang, Wen‐Yu; Chen, Chien-Jen

doi:10.1097/00006454-199802000-00012

Cited by 37 publications

(39 citation statements)

References 25 publications

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“…Lu et al [24] reported that no statistically significant difference in risk factors could be found among HCV antibody positive and negative children.…”

Section: Discussionmentioning

confidence: 96%

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Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children

El-Raziky¹

2007

WJG

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AIM:To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS:Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver disease. RESULTS:We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION:Asymptomatic HCV infection is detectable in 2.02% Egyptian children.

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“…Lu et al [24] reported that no statistically significant difference in risk factors could be found among HCV antibody positive and negative children.…”

Section: Discussionmentioning

confidence: 96%

“…Ultrasonog raphy revealed evidence of peripor tal thickening in only one case (5.6%). Lu et al [24] reported that none of their HCV children had sonographic parenchymal changes in the liver when studying an endemic area in Taiwan.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children

El-Raziky¹

2007

WJG

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“…In addition, seroreversion of anti-HCV in recovered cases has been observed in other areas endemic for HCV. 35,36 This might be another cause of underestimation of the prevalence. However, the probabilities of these two situations are too small to influence the prevalence of HCV infection estimated by anti-HCV.…”

Section: Discussionmentioning

confidence: 99%

Predicting the prevalence of antibody to hepatitis C virus (HCV) in a community by the prevalence of elevated levels of alanine aminotransferase: a method to identify areas endemic for HCV.

Lu¹,

Wang²,

Kuo³

et al. 2002

The American Journal of Tropical Medicine and Hygiene

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Abstract. To identify areas endemic for hepatitis C virus (HCV), we attempted to predict the prevalence of antibody to HCV (anti-HCV) in a community by the prevalence of elevated levels of alanine aminotransferase (ALT). The results of health examinations of 2,273 women Ն 40 years old in five townships in central Taiwan were analyzed. The overall prevalence of elevated ALT levels was 11.6%. A township (20.3%) and 10 villages were identified as having a high prevalence (17.9−40.0%) of elevated ALT levels. Five communities with variant rates of elevated ALT levels, which ranged from 8.0% to 27.3%, were selected for correlation with the prevalence of anti-HCV among adults (Ն 40 years old). The prevalence of anti-HCV, which ranged from 10.1% to 72.1%, were obtained by community screenings and/or hospital-based studies. The correlation equation used was the prevalence of anti-HCV (%) ‫ס‬ 3.33 × (prevalence of elevated ALT levels (%) -5.7%) (r 2 ‫ס‬ 0.94, P < 0.01). Using this method, areas endemic for HCV can be identified by determining the community prevalence of elevated ALT levels.

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“…Majority of Taiwanese HBV carriers were infected with HBV perinatally before 3 years of age. Infection occurring after 3 years of age was less frequent and rarely developed into a chronic status [29,30]. Hence, most cases enrolled in our study with dual HBV and HCV infection were likely chronic HBV carriers superinfected by HCV [31].…”

Section: Discussionmentioning

confidence: 87%

634 Occult and Overt HBV Co-Infections Independently Predict Postoperative Prognosis in HCV-Associated Hepatocellular Carcinoma

Chang¹,

Yeh²

2013

Journal of Hepatology

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Objective and Background: The roles of chronic hepatitis B virus (HBV) co-infection (CI) in carcinogenesis of hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) remained controversial. To gain new insights into this issue, we investigated the postoperative prognostic value of HBVCI in HCV-associated HCC.Methods: A study cohort of 115 liver tissues obtained from the noncancerous parts of surgically removed HCV-associated HCCs were subjected to virological analysis in a tertiary care setting. were independently associated with unfavorable disease-free survival. Patients with occult HBVCI had a shorter disease-free (P = 0.002), a shorter overall survival (P = 0.026), a higher bilirubin level (P = 0.003) and a higher prevalence of precore G1896A mutation (P = 0.006) compared with those with overt HBVCI. Conclusion:Occult and overt HBVCI served as independent predictors for postoperative survival in HCV-associated HCC.

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Prevalence and manifestations of hepatitis C seropositivity in children in an endemic area

Abstract: Only 36% (4 of 11) of anti-HCV-positive children had an OD of > 2.0. Subjects with sequentially low OD might recover from chronic HCV infection without detectable HCV RNA and with normal alanine aminotransferase values.

Cited by 37 publications

References 25 publications

Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children

Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children

Predicting the prevalence of antibody to hepatitis C virus (HCV) in a community by the prevalence of elevated levels of alanine aminotransferase: a method to identify areas endemic for HCV.

634 Occult and Overt HBV Co-Infections Independently Predict Postoperative Prognosis in HCV-Associated Hepatocellular Carcinoma

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