Prevalence and Metabolic Predictors for Early Diagnosed Prediabetes in Women with Previous Gestational Diabetes: Observational Cohort Study

Jotić, Aleksandra; Stoiljković, Milica; Miličić, Tanja; Lalić, Katarina; Lukic, Ljiljana; Maćešić, Marija; Gajovic, Jelena N Stanarcic; Milovancevic, Mina M.; Dugalić, Miroslava Gojnić; Jeremić, Veljko; Lalić, Nebojša

doi:10.1007/s13300-021-01144-5

Cited by 3 publications

(2 citation statements)

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“…In addition to the higher insulin requirements, HbA1c levels were significantly higher late in pregnancy in the women who developed T2DM within the first year PP. This has also been found in a study by Jotic et al [ 21 ], who aimed to determine the prevalence and predictors for prediabetes among women with previous GDM. Out of 186 women with previous GDM, 43% developed pDM within the first 4-12 weeks PP.…”

Section: Discussionsupporting

confidence: 64%

“…In the study by Jotic et al [ 21 ], lipid profiles were also evaluated in the third trimester of pregnancy and the authors found that the women who developed pDM had higher levels of total cholesterol, triglycerides, and LDL, whereas HDL levels were lower. In our study, there was no difference in lipids late in pregnancy when comparing the 3 groups, apart from total cholesterol levels, which surprisingly were lower in the group of women who later developed T2DM.…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Metabolic Characterization of Women With Gestational Diabetes Mellitus Within the First Year Postpartum

Knudsen,

Knorr,

Prange

et al. 2024

Journal of the Endocrine Society

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Context Women with gestational diabetes mellitus (GDM) have an increased risk of long-term complications, including impaired glucose metabolism, type 2 diabetes (T2DM), cardiovascular disease, and obesity. In current clinical practice, a one-size-fits-all approach to GDM is applied, although heterogeneity among women with GDM has been recognized. Objective To give the most adequate preventive care and post-partum (PP) guidance, we aimed to make a metabolic characterization and identify subgroups of women with previous GDM within the first year PP. Methods In this prospective cohort study, we collected data in gestational week 34-38, at 3 months, and 1 year PP on women with GDM, who participated in a PP follow-up program in Central Region Denmark from April 2019- December 2022. Results In total 1270 women were included in the program in late pregnancy. Of the 768 women participating in either oral glucose tolerance test (OGTT) 3 months PP (n = 545) or 1-year follow-up (n = 493) or both (n = 261), 608 (79.2%) were normoglycemic, 137 (17.8%) had prediabetes, 20 (2.6%) had T2DM, and 3 (0.4%) had developed T1DM. More than 40% of the women gained weight in the first year PP, compared to their pregestational weight. Conclusion Our study shows that 20.8% of women with GDM who volunteered to participate in a clinical follow up programme developed prediabetes or diabetes (T1DM and T2DM) within the first year PP. The GDM diagnosis encompasses a heterogenetic group of women and a deeper characterization may provide an opportunity for a more personalized risk assessment to prevent the progression to T2DM.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%