Prevalence and mortality in children with congenital diaphragmatic hernia: a multicountry study

Politis, Maria D.; Bermejo‐Sánchez, Eva; Canfield, Mark A.; Contiero, Paolo; Cragan, Janet D.; Dastgiri, Saeed; Walle, Hermien E. K. de; Feldkamp, Marcia L.; Nance, Amy; Groisman, Boris; Gatt, Miriam; Benavides‐Lara, Adriana; Hurtado‐Villa, Paula; Källén, Karin; Landau, Danielle; Lelong, Nathalie; López-Camelo, Jorge S.; Martínez, Laura; Morgan, Margery; Mutchinick, Osvaldo M.; Pierini, Anna; Rißmann, Anke; Šípek, A; Szabová, Elena; Wertelecki, Wladimir; Zarante, Ignacio; Kancherla, Vijaya; Mastroiacovo, Pierpaolo; Nembhard, Wendy N.

doi:10.1016/j.annepidem.2020.11.007

Cited by 70 publications

(49 citation statements)

References 40 publications

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“…Study limitations include that, despite a high effort with repeated attempts to contact patients, the number of recruited patients is relatively low. This can be explained by the low prevalence of CDH of 2.6 out of 10,000 total births and a mortality rate of 37.7% [27] and the single-center setting of this investigation. A further fact decreasing the number of potential participants is the fact that we only recruited children between 6 and 16 years of age in order to assess changes of the examined parameters in children and adolescents.…”

Section: Discussionmentioning

confidence: 77%

Volatile Organic Compounds, Bacterial Airway Microbiome, Spirometry and Exercise Performance of Patients after Surgical Repair of Congenital Diaphragmatic Hernia

et al. 2021

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The aim of this study was to analyze the exhaled volatile organic compounds (VOCs) profile, airway microbiome, lung function and exercise performance in congenital diaphragmatic hernia (CDH) patients compared to healthy age and sex-matched controls. A total of nine patients (median age 9 years, range 6–13 years) treated for CDH were included. Exhaled VOCs were measured by GC–MS. Airway microbiome was determined from deep induced sputum by 16S rRNA gene sequencing. Patients underwent conventional spirometry and exhausting bicycle spiroergometry. The exhaled VOC profile showed significantly higher levels of cyclohexane and significantly lower levels of acetone and 2-methylbutane in CDH patients. Microbiome analysis revealed no significant differences for alpha-diversity, beta-diversity and LefSe analysis. CDH patients had significantly lower relative abundances of Pasteurellales and Pasteurellaceae. CDH patients exhibited a significantly reduced Tiffeneau Index. Spiroergometry showed no significant differences. This is the first study to report the VOCs profile and airway microbiome in patients with CDH. Elevations of cyclohexane observed in the CDH group have also been reported in cases of lung cancer and pneumonia. CDH patients had no signs of impaired physical performance capacity, fueling controversial reports in the literature.

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Section: Discussionmentioning

confidence: 77%

Volatile Organic Compounds, Bacterial Airway Microbiome, Spirometry and Exercise Performance of Patients after Surgical Repair of Congenital Diaphragmatic Hernia

et al. 2021

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“…CDH is a pediatric clinical emergency involving the respiratory and circulatory symptoms, respiratory failure caused by pulmonary hypoplasia and pulmonary hypertension is the main cause of death ( 105 ).…”

Section: Manuscript Formattingmentioning

confidence: 99%

Application of B-Type Natriuretic Peptide in Neonatal Diseases

et al. 2021

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Numerous congenital or secondary diseases, including, heart disease, respiratory disease, sepsis and many others, can lead to neonatal death. B-type natriuretic peptide (BNP) is a peptide hormone secreted by ventricular cells following an increase in ventricular wall tension. BNP functions to promote vasodilation, diuresis, and sodium release to regulate blood pressure. BNP is a sensitive index reflecting ventricular function, which may aid the diagnosis and monitoring of various neonatal diseases. In neonates, there is currently no consensus on a reference BNP level, as the plasma BNP concentration of healthy newborns varies with age, peaks in the first week after birth, and then gradually decreased to a stable level. In disease states, the correlation between the plasma BNP concentration and the results of echocardiography is good, which is of great significance in the screening, monitoring, and prognosis evaluation of neonatal cardiovascular diseases, including congenital heart disease, patent ductus arteriosus, etcetera. It also facilitates the judgment of the efficacy of treatment and perioperative management. Moreover, the monitoring of plasma BNP concentration provides guidance for the diagnosis, evaluation, and treatment selection of certain neonatal respiratory diseases and neonatal sepsis. This review summarizes the normal BNP values and discusses the application value of BNP in relation to physiological and pathological aspects in neonates.

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“…Because of birth defects impact on child morbidity and mortality, there are many precedents of childhood mortality analyses that incorporate birth defects registry data, providing an effective mechanism for monitoring the survival and mortality risks of children with selected major birth defects, such as congenital heart disease ( 47 ), esophageal atresia ( 48 ), spina bifida ( 49 ), diaphragmatic hernia ( 50 ), and omphalocele ( 51 ).…”

Section: The Benefit Of Birth Defects Surveillance To Other Health-related Programsmentioning

confidence: 99%

Why are Birth Defects Surveillance Programs Important?

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Sanseverino

Schmalfuss

et al. 2021

Front. Public Health

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Prevalence and mortality in children with congenital diaphragmatic hernia: a multicountry study

Cited by 70 publications

References 40 publications

Volatile Organic Compounds, Bacterial Airway Microbiome, Spirometry and Exercise Performance of Patients after Surgical Repair of Congenital Diaphragmatic Hernia

Volatile Organic Compounds, Bacterial Airway Microbiome, Spirometry and Exercise Performance of Patients after Surgical Repair of Congenital Diaphragmatic Hernia

Application of B-Type Natriuretic Peptide in Neonatal Diseases

Why are Birth Defects Surveillance Programs Important?

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