Prevalence and pattern of antibiotic resistance of gram-negative bacteria isolated from urinary tract infections in patients referring to Neka laboratories-Iran

Abstract

Introductionrinary tract infection is an inflammatory response of the urethra to the invasion of pathogenic microorganisms (1). This infection is of the highest importance after respiratory tract infection and is the second most common infection in children and adults and the most important infection in infants. In the world, every year, 150 million people are affected by this infection, and includes 35% of hospital infections (2-4). Urinary tract infections are one of the most common infections that occur at different ages and mis-treatment of it can lead to serious complications such as disorders of the urinary tract, hypertension, uremia and early delivery and even abortions in pregnant women. More than 50% of women get UTIs at least once in their lifetime. The severity of these infections depends on factors such as bacterial virulence. The risk factors for urinary tract infection include host characteristics, host behavior, and bacterial characteristics. Sexual activity and contraceptive methods are also important risk factors for the development of symptomatic urinary tract infection. Cell receptor characteristics, anatomy differences and host genetics are risk factors for recurrence of infection (5-6). Urinary tract infections U

Evaluation of in vitro effect of Fosfomycin on resistant Gram-negative pathogens in urinary tract infection

“…Zare et al [1] and Fajfr et al [7] reported that E. coli was the most predominant isolated pathogen (66.7%,.45 %,51.3%) respectively.This documented the principal role of E. coli in causing UTI.…”

“…Urinary tract infection (UTI) is considered one of the most frequent problems found in different clinical settings and accounts for about a quarter of all antimicrobial prescriptions. Every year, 150 million people worldwide are affected by this infection, including 35% of hospital infections [1]. Escherichia coli (E.coli) is the main pathogen responsible for uncomplicated cystitis and pyelonephritis, followed by other species of Enterobacteriaceae, such as Proteus mirabilis and mostly Klebsiella pneumoniae, Gram-positive pathogens, such as Enterococcus faecalis and Staphylococcus saprophyticus also may be included [2].…”

The Most Predominant Gram Negative Bacteria in a Public Hospital

“…A systematic review and meta-analysis was conducted by Aliyu et al and stated that among nursing home residents, Escherichia coli accounted for the largest proportion of multidrug-resistant gramnegative bacterial isolates [14]. Moreover, Zare et al reported that among gram-negative bacteria isolated from patients with urinary tract infections, the most commonly isolated bacteria in the urine included Escherichia coli (45%), Enterobacter (12%), Klebsiella (3.14%), and Pseudomonas isolates (1.22%) [15]. Additionally, saber et al and Gajdács et al reported that Escherichia coli has been documented to be the most common pathogen associated with urinary tract infections in many countries causing both community-and hospital-acquired UTI [16,17].…”

Distribution of dfrA1 and cat1 antibiotic resistance genes in uropathogenic Escherichia coli isolated from teens pregnant women in Iraq

“…UTIs are mainly the second most common infections bacterial after respiratory tract infections, seen in primary care. UTIs is a bacterial invasion-induced inflammatory reactions of the urothelium related to bacteriuria and pyuria [2]. Anatomically, divided of UTIs are into two portions, pyelonephritis is an upper urinary tract portion (ureters, renal pelvis, and kidneys), and cystitis is a lower urinary tract portion (urethra and urinary bladder) [3].…”