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Introductionrinary tract infection is an inflammatory response of the urethra to the invasion of pathogenic microorganisms (1). This infection is of the highest importance after respiratory tract infection and is the second most common infection in children and adults and the most important infection in infants. In the world, every year, 150 million people are affected by this infection, and includes 35% of hospital infections (2-4). Urinary tract infections are one of the most common infections that occur at different ages and mis-treatment of it can lead to serious complications such as disorders of the urinary tract, hypertension, uremia and early delivery and even abortions in pregnant women. More than 50% of women get UTIs at least once in their lifetime. The severity of these infections depends on factors such as bacterial virulence. The risk factors for urinary tract infection include host characteristics, host behavior, and bacterial characteristics. Sexual activity and contraceptive methods are also important risk factors for the development of symptomatic urinary tract infection. Cell receptor characteristics, anatomy differences and host genetics are risk factors for recurrence of infection (5-6). Urinary tract infections U

ChemInform Abstract With a view to achieving better therapeutic activity, 26 urea and 26 thiourea derivatives of type (IIIa) and (IIIb), resp., are synthesized (yield: 40-90%). All compounds show moderate antimicrobial activity.

ChemInform Abstract The title compounds (I) are synthesized from the corresponding Schiff bases and thiolactic or thiomalic acid. All (I) exhibit moderate antimicrobial activity.

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