Prevalence and Pattern of Lymph Node Metastasis in Malignant Pleural Mesothelioma

Rahman, Abdel Rahman M. Abdel; Gaafar, Rabab; Baki, Hoda Abd El; Hosieny, Hesham M. El; Aboulkasem, Fatma; Farahat, Eman G.; Nouh, Mohamed A.; Mansour, Kamal A.

doi:10.1016/j.athoracsur.2008.04.012

Cited by 26 publications

(9 citation statements)

References 20 publications

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“…necessarily involving intrapulmonary (previously N1) glands. This data is concordant with human cadaveric studies reported by Okiemy [36] and is reflected in the observations of Rahman, who reported frequent involvement of mediastinal (previously N2) nodes in patients with pleural invasion in the absence of intrapulmonary (previously N1) nodes [37]. Furthermore, Rusch et al recently reported no difference in survival between patients with intrapulmonary (previously N1) vs. mediastinal (previously N2) disease (median survival 17 months versus 13 months, HR 1.11 (p = 0.2771)), but a significant difference in those with no node involvement (N0) relative to those with any node involvement (previous N1 HR 1.26, p = 0.0071 vs. N0; previous N2 HR 1.40, p < 0.0001 vs. N0) [38].…”

Section: Stagingsupporting

confidence: 93%

Progress and challenges in Mesothelioma: From bench to bedside

Blyth

Murphy

2018

Respiratory Medicine

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Malignant Pleural Mesothelioma (MPM) is currently an incurable cancer with a typical survival of 1 year from the time of diagnosis. The recent genomic and transcriptomic characterization of MPM presents new opportunities and challenges for MPM researchers. Recent advances in clinical and laboratory diagnostics, and proposals for an updated, data-driven, staging system, also present new challenges for clinicians and hospital services involved in MPM care. The aim of this review is first to introduce the reader to the topic of MPM, a disease that is causally linked to prior, typically occupational, exposure to asbestos fibres. Secondly, we will discuss MPM from the clinical and laboratory perspectives, including reviews of current and evolving therapies and our present understanding of the molecular basis of the disease. Finally, we will attempt to identify critical knowledge gaps that currently prevent more effective treatment, including the challenges involved in early detection and chemoprophylaxis.

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Section: Stagingsupporting

confidence: 93%

Progress and challenges in Mesothelioma: From bench to bedside

Blyth

Murphy

2018

Respiratory Medicine

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“…Mediastinal and hilar lymph node enlargement was significantly more common in patients with MPD, which may have been related to the larger proportion of lung cancer patients in the MPD group. Hilar lymph nodes drain lungs and visceral pleura, whereas internal mammary, cardiophrenic, extrapleural, and intercostal nodes drain parietal pleura ( 8 19 20 ). In a study that addressed the prevalence of lymph node metastasis in MPM, Abdel Rahman et al ( 20 ) concluded that hilar node involvement occurred secondary to parenchymal infiltration and was not due to direct spread from pleura, whereas extrapleural and cardiophrenic nodes were primarily involved in MPM.…”

Section: Discussionmentioning

confidence: 99%

“…Hilar lymph nodes drain lungs and visceral pleura, whereas internal mammary, cardiophrenic, extrapleural, and intercostal nodes drain parietal pleura ( 8 19 20 ). In a study that addressed the prevalence of lymph node metastasis in MPM, Abdel Rahman et al ( 20 ) concluded that hilar node involvement occurred secondary to parenchymal infiltration and was not due to direct spread from pleura, whereas extrapleural and cardiophrenic nodes were primarily involved in MPM. Feragalli et al ( 19 ) concluded that the presence of extrapleural and cardiophrenic nodes associated with other signs of MPM, especially with involvement of mediastinal pleura and volume loss of affected hemithorax, could play an important diagnostic role in the early diagnosis of MPM.…”

Section: Discussionmentioning

confidence: 99%

Multidetector CT Findings and Differential Diagnoses of Malignant Pleural Mesothelioma and Metastatic Pleural Diseases in Korea

Kim

Lee

et al. 2016

Korean J Radiol

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ObjectiveTo compare the multidetector CT (MDCT) features of malignant pleural mesothelioma (MPM) and metastatic pleural disease (MPD).Materials and MethodsThe authors reviewed the MDCT images of 167 patients, 103 patients with MPM and 64 patients with MPD. All 167 cases were pathologically confirmed by sonography-guided needle biopsy of pleura, thoracoscopic pleural biopsy, or open thoracotomy. CT features were evaluated with respect to pleural effusion, pleural thickening, invasion of other organs, lung abnormality, lymphadenopathy, mediastinal shifting, thoracic volume decrease, asbestosis, and the presence of pleural plaque.ResultsPleural thickening was the most common CT finding in MPM (96.1%) and MPD (93.8%). Circumferential pleural thickening (31.1% vs. 10.9%, odds ratio [OR] 3.670), thickening of fissural pleura (83.5% vs. 67.2%, OR 2.471), thickening of diaphragmatic pleura (90.3% vs. 73.4%, OR 3.364), pleural mass (38.8% vs. 23.4%, OR 2.074), pericardial involvement (56.3% vs. 20.3%, OR 5.056), and pleural plaque (66.0% vs. 21.9%, OR 6.939) were more frequently seen in MPM than in MPD. On the other hand, nodular pleural thickening (59.2% vs. 76.6%, OR 0.445), hilar lymph node metastasis (5.8% vs. 20.3%, OR 0.243), mediastinal lymph node metastasis (10.7% vs. 37.5%, OR 0.199), and hematogenous lung metastasis (9.7% vs. 29.2%, OR 0.261) were less frequent in MPM than in MPD. When we analyzed MPD from extrathoracic malignancy (EMPD) separately and compared them to MPM, circumferential pleural thickening, thickening of interlobar fissure, pericardial involvement and presence of pleural plaque were significant findings indicating MPM than EMPD. MPM had significantly lower occurrence of hematogenous lung metastasis, as compared with EMPD.ConclusionAwareness of frequent and infrequent CT findings could aid in distinguishing MPM from MPD.

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“…The prevalence of lymph node metastasis in conventional mesothelioma has been evaluated. Rahman et al reported that 18 of 53 patients (34.0%) with malignant pleural mesothelioma had positive lymph node involvement at the time of surgery (17). In addition, Edwards et al reported that 44 of 92 consecutive patients (47.8%) with malignant mesothelioma who underwent extrapleural pneumonectomy had positive lymph node involvement (18).…”

Section: Discussionmentioning

confidence: 99%

Primary intrahepatic malignant mesothelioma with multiple lymphadenopathies due to non-tuberculous mycobacteria: A case report and review of the literature

et al. 2013

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Primary intrahepatic malignant mesothelioma (PIHMM) is an extremely rare tumor with clinicopathological characteristics that remain to be elucidated. The current study presents the case of a 68-year-old female with PIHMM and multiple lymphadenopathies due to non-tuberculous mycobacteria. The patient presented with an intrahepatic tumor, 70 mm in diameter, in the right lobe of the liver. An ultrasound-guided fine-needle aspiration biopsy of the liver tumor revealed findings that were consistent with an intrahepatic malignant mesothelioma. The systemic lymph node swellings were due to epithelioid granulomas that were caused by non-tuberculous mycobacteria. However, a hepatic rupture occurred due to the rapid growth of the liver tumor and consequently, a surgical resection was not performed. A review of the literature revealed that the clinicopathological characteristics of PIHMM are similar to those of non-occupational mesothelioma. However, PIHMM is usually a solitary tumor and is rarely associated with cavity effusion in contrast with conventional mesothelioma. Therefore, surgical resection with curative intent is often recommended for patients with PIHMM.

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Prevalence and Pattern of Lymph Node Metastasis in Malignant Pleural Mesothelioma

Cited by 26 publications

References 20 publications

Progress and challenges in Mesothelioma: From bench to bedside

Progress and challenges in Mesothelioma: From bench to bedside

Multidetector CT Findings and Differential Diagnoses of Malignant Pleural Mesothelioma and Metastatic Pleural Diseases in Korea

Primary intrahepatic malignant mesothelioma with multiple lymphadenopathies due to non-tuberculous mycobacteria: A case report and review of the literature

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