Prevalence and predictors of abnormal bone mineral metabolism in recently diagnosed adult celiac patients

Chakravarthi, Sudheer; Jain, Kapil; Kochhar, Rakesh; Bhadada, Sanjay Kumar; Khandelwal, Niranjan; Bhansali, Anil; Dutta, Usha; Nain, C. K.; Singh, Kartar

doi:10.1007/s12664-012-0216-y

Cited by 18 publications

(11 citation statements)

References 22 publications

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“…An Indian report showed low BMD measurement in earlier age of CD. In this study, all CD patients were also less than 50 years old, 39% of patients had normal BMD, and 61% of newly diagnosed CD cases had low BMD and lumbar and femoral BMD were not separated, but they did not mention to the confounding risk factors for low BMD [33]. Pritcha et al also showed that 56% of CD patients had normal BMD, 28% osteopenia, and 5% osteoporosis.…”

Section: Discussionmentioning

confidence: 79%

Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review

Ganji

Moghbeli

Sadeghi

et al. 2019

Nutr J

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Background Celiac disease (CD) is known as a reason of metabolic osteopathy. Progression of non-invasive methods such as bone densitometry has shown that an important ratio of CD cases is faced with impaired bone mass and such cases are prone to bone fractures. Variety of low bone mineral density in CD is probably because of ignored confounding factors such as age, menopause, and drug. The aim of our study was to systematically review the osteoporosis and osteopenia incidences among premenopausal females and males with CD. Methods This systematic review was done based on preferred reporting items for systematic reviews (PRISMA) guidelines. PubMed and Scopus and Cochran databases were searched according to the relevant medical subject headings (MeSH) of CD and bone mineral density until 2018. Prevalence of osteopenia and osteoporosis were used as effect size for meta-analysis. Cochrane Q ( p < 0.05) and I 2 index were presented to reveal the heterogeneity. Results 54 eligible full text reviews were included and nineteen selected for data extraction. Eleven articles didn’t have our inclusion criteria and had ignored confounding factors like age and menopause, and we excluded; data extraction was done in eight studies. A total of 563 premenopausal women and men who were from, UK, Brazil, India, Hungary, and Poland were included. The pooled prevalence of osteoporosis was 14.4% [95%CI: 9–20.5%] (Cochrane Q = 7.889, p = 0.96, I 2 = 49.29%), and osteopenia was 39.6% [31.1–48.8%] (Cochrane Q = 14.24, p = 0.07, I 2 = 71.92%), respectively. Conclusion Our findings suggest that bone loss is more prevalent in celiac disease and can be associated with increased risk of fracture. However, but results are pooled prevalence and we need more case –control studies with more sample size and consideration of confounding factors.

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Section: Discussionmentioning

confidence: 79%

Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review

Ganji

Moghbeli

Sadeghi

et al. 2019

Nutr J

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“…There have been numerous reports on the insufficiency of fat -soluble vitamins in adult subjects with gluten enteropathy. 29,30 The plasma or serum concentrations of α -tocopherol exceeding 16.2 μmol/l are considered as sufficient; the levels ranging from 11.6 to 16.2 indicate low vitamin E levels, and the levels of less than 11.6 μmol/l suggest a deficiency. Recently, it has been proposed that the adequate plasma concentration of α -tocopherol to prevent neoplasm and cardiovascular disorders is more than 30 μmol/l.…”

Section: Results Blood Tests In Controls and Celiac Patientsmentioning

confidence: 99%

Alterations in serum levels of selected markers of oxidative imbalance in adult celiac patients with extraintestinal manifestations - pilot study

Piątek-Guziewicz¹,

Zagrodzki²,

Paśko³

et al. 2017

Polish Archives of Internal Medicine

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“…The observed prevalence of low BMD in this consecutively diagnosed cohort of adult CD patients was approximately 60%, in line with previously reported prevalence data (40%-75%). [4][5][6][7][8][9][10] The gender ratio reflected the usual distribution of CD (females:males ¼ 2:1), making our cohort a suitable representation of the gender distribution in CD. 13,23 Previous studies considered primarily female coeliac patients (both pre-and post-menopausal), patients who had been on a GFD for variable periods of time or also included children in their evaluation, representing important biases in the assessment of the prevalence of BMD alterations in adults with CD.…”

Section: Discussionmentioning

confidence: 99%

“…3 It has been demonstrated that up to 75% of patients with coeliac disease (CD) suffer from bone mass loss (osteopenia or osteoporosis). [4][5][6][7][8][9][10] Despite the strong association between low BMD and CD, guidelines do not express with certainty whether each patient with a new diagnosis of CD should undergo a DEXA scan. [11][12][13] At present, DEXA investigations are suggested only for patients with CD who are peri-or post-menopausal females or males over 55 years and those with overt malabsorption or a history of fragility fractures.…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with osteoporosis in a cohort of prospectively diagnosed adult coeliac patients

Galli¹,

Lahner²,

Conti³

et al. 2018

UEG Journal

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Background: Up to 75% of patients with untreated coeliac disease (CD) present with osteopenia or osteoporosis. Guidelines do not express with certainty whether each patient with newly diagnosed CD should undergo a dual-energy x-ray absorptiometry (DEXA) scan. Aim: The aim of this article is to evaluate the prevalence of bone mineral density (BMD) alterations at diagnosis and risk factors associated with osteoporosis. Methods: A total of 214 adult patients (median age 38 years; female ¼ 71.5%) newly diagnosed with CD underwent DEXA. The patients were divided into three groups: patients with normal BMD, those with osteopenia and those with osteoporosis. Clinical, histological and serological features were assessed and compared among the three groups. Logistic regression including relevant independent variables was performed. Results: DEXA indicated that 39.7%, 42.5% and 17.8% of the CD patients had normal BMD, osteopenia and osteoporosis, respectively. Logistic regression indicated that features significantly associated with osteoporosis were male gender (OR 4.7; 95%CI 1.1 to 20.8), age !45 years (OR 6.5; 95% CI 1.3 to 32.2), underweight (OR 7.4; 95% CI 1.3 to 42.5) and greater histological damage (Marsh 3C; OR 5.8; 95% CI 1.4 to 24.1). Conclusions: BMD alterations were found in 60.3% of newly diagnosed adult coeliac patients. Osteoporosis was significantly associated with age !45 years, male gender, underweight and Marsh 3C, suggesting that at CD diagnosis, a DEXA scan might be beneficial, particularly in these subgroups of patients. Key summary. Dual-energy x-ray absorptiometry (DEXA) scans have been recommended only for coeliac disease (CD) patients who are peri-or post-menopausal females or males over 55 years and those with overt malabsorption or a history of fragility fractures. . In this study, bone mineral density alterations were found in 60.3% of newly diagnosed adult CD patients.. Osteoporosis was significantly associated with age !45 years, male gender, underweight and Marsh 3C, suggesting that at CD diagnosis, a DEXA scan might be beneficial.

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Prevalence and predictors of abnormal bone mineral metabolism in recently diagnosed adult celiac patients

Abstract: Low BMD is common in newly diagnosed adult celiac patients with approximately one fifth of them having osteoporosis. BMD should be measured in all newly diagnosed celiac patients and calcium and vitamin D supplementation included in the treatment regimen.

Cited by 18 publications

References 22 publications

Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review

Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review

Alterations in serum levels of selected markers of oxidative imbalance in adult celiac patients with extraintestinal manifestations - pilot study

Risk factors associated with osteoporosis in a cohort of prospectively diagnosed adult coeliac patients

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