Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review

Abstract

Background Celiac disease (CD) is known as a reason of metabolic osteopathy. Progression of non-invasive methods such as bone densitometry has shown that an important ratio of CD cases is faced with impaired bone mass and such cases are prone to bone fractures. Variety of low bone mineral density in CD is probably because of ignored confounding factors such as age, menopause, and drug. The aim of our study was to systematically review the osteoporosis and osteopenia incidences among premenopausal females and males with CD. Methods This systematic review was done based on preferred reporting items for systematic reviews (PRISMA) guidelines. PubMed and Scopus and Cochran databases were searched according to the relevant medical subject headings (MeSH) of CD and bone mineral density until 2018. Prevalence of osteopenia and osteoporosis were used as effect size for meta-analysis. Cochrane Q ( p < 0.05) and I 2 index were presented to reveal the heterogeneity. Results 54 eligible full text reviews were included and nineteen selected for data extraction. Eleven articles didn’t have our inclusion criteria and had ignored confounding factors like age and menopause, and we excluded; data extraction was done in eight studies. A total of 563 premenopausal women and men who were from, UK, Brazil, India, Hungary, and Poland were included. The pooled prevalence of osteoporosis was 14.4% [95%CI: 9–20.5%] (Cochrane Q = 7.889, p = 0.96, I 2 = 49.29%), and osteopenia was 39.6% [31.1–48.8%] (Cochrane Q = 14.24, p = 0.07, I 2 = 71.92%), respectively. Conclusion Our findings suggest that bone loss is more prevalent in celiac disease and can be associated with increased risk of fracture. However, but results are pooled prevalence and we need more case –control studies with more sample size and consideration of confounding factors.

No major reduction in bone mineral density after long-term treatment of patients with Celiac Disease

“…A recent meta-analysis by Ganji et al [32] on the prevalence of osteoporosis and osteopenia in CD reported a pooled prevalence of osteoporosis at lumbar spine and hip at 16.3% and 13.3%, respectively. The same study reported a pooled prevalence of osteopenia at lumbar spine and hip at 41.9% and 46.9%, respectively.…”

Translation, Cultural Adaptation, and Evaluation of a Brazilian Portuguese Questionnaire to Estimate the Self-Reported Prevalence of Gluten-Related Disorders and Adherence to Gluten-Free Diet

“…In fact, survey studies have proven that following a GFD can improve the health-related quality of life in CD patients in spite of the difficulties of following the diet [1]. Different from wheat allergy and NCGS, untreated CD could affect the nutritional status and predispose to other conditions such as osteoporosis [2,3], anemia [4], and intestinal T-cell lymphoma [5]. On its own, following a GFD without medical/dietitian advice can predispose not only to deficiencies in micronutrients, but also to low fiber intake [6,7] increasing the risk of dyslipidemia [8,9].…”

Impact of resistance exercises and nano-curcumin on synovial levels of collagenase and nitric oxide in women with knee osteoarthritis

“…OA is the most common musculoskeletal disorder and causes social and economic disabilities in the elderly population [2]. Various risk factors are associated with OA including age, obesity, occupation, gender (women are more susceptible than men), inheritance, metabolic diseases, knee trauma, and inertia [3][4][5]. The most common symptoms of OA are pain, morning stiffness, mobility limitation of joint, bone and soft tissue sensitivity, swelling, and clicking or cracking sound during joint bending and effusion.…”