Prevalence and predictors of atrial fibrillation type among individuals with recent onset of atrial fibrillation

Repilado, Francisco Javier Ruperti; Doerig, Laura; Blum, Steffen; Aeschbacher, Stefanie; Krisai, Philipp; Ammann, Peter; Erné, Paul; Moschovitis, Giorgio; Valentino, Marcello Di; Shah, Dipen; Schläpfer, Jürg; Stempfel, Samuel; Kühne, Michael; Sticherling, Christian; Oßwald, Stefan; Conen, David

doi:10.4414/smw.2018.14652

Cited by 9 publications

(23 citation statements)

References 1 publication

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“…In our study, women had poorer perceived health as determined by the EQ-5D. This is consistent with the observations of the BEAT-AF study [21] and EORP-AF trial [17]. In both genders, perceived health status was better in those patients subjected to a rhythm control management strategy versus rate control, though the scores were comparatively higher in men.…”

Section: Discussionsupporting

confidence: 91%

“…Other studies have evidenced that if sinus rhythm is achieved and maintained, similar improvement of quality of life is observed in both genders [23]. In the BATE-AF trial, the symptoms burden decreased 56% among those patients subjected to rhythm control, but only 28.4% in the absence of such treatment [21].…”

Section: Discussionmentioning

confidence: 78%

“…On stratifying according to symptoms, in the presence of typical symptoms, women were less likely to be subjected to rhythm control strategies (p = 0.002). On the other hand, the women in the BEAT-AF study [21] had a significantly lower prevalence of interventions (understood as ECV or ablation) than the men (30.7% versus 38.9%; p = 0.002).…”

Section: Discussionmentioning

confidence: 89%

“…This is in contrast to the findings of the EORP-AF trial [17], where the prevalence of paroxysmal AF was seen to be higher in females (28.5% versus 25.1%), with very similar permanent AF rates in both groups (17.5% and 17.1%). Likewise, the BEAT-AF [21], a prospective, multicenter observational study of 1553 patients with AF (mean age 70 ± 11 in women and 67 ± 12 years in men), reported a higher frequency of paroxysmal AF in women (60.6% versus 53.7%; p = 0.04). In further considering gender-related differences, a multivariate analysis found the female gender to remain as a potent predictor of symptoms (odds ratio [OR]: 2.6; 95% confidence interval [95%CI], 2.1-3.4; p < 0.0001), adjusted for variables such as age or the presence of comorbidities, within a sub-study of the ORBIT AF registry [22].…”

Section: Discussionmentioning

confidence: 98%

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Differences in the Clinical Profile and Management of Atrial Fibrillation According to Gender. Results of the REgistro GallEgo Intercéntrico de Fibrilación Auricular (REGUEIFA) Trial

Durán-Bobin

Elices-Teja

González‐Melchor

et al. 2021

JCM

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To analyze the clinical profile and therapeutic strategy in atrial fibrillation (AF) according to gender in a contemporaneous patient cohort a prospective, multicenter observational study was performed on consecutive patients diagnosed with AF and assessed by cardiology units in the region of Galicia (Spain). A total of 1007 patients were included, of which 32.3% were women. The mean age of the women was significantly greater than that of the men (71.6 versus 65.7 years; p < 0.001), with a higher prevalence of hypertension (HTN) and valve disease. Women more often reported symptoms related to arrhythmia (28.2% in EHRA class I versus 36.4% in men), with a poorer level of symptoms (EHRA classes IIb and III). Thromboembolic risk was significantly higher among women (CHA2DS2-VASc 3 ± 1.3 versus 2 ± 1.5), in the same way as bleeding risk (HAS-BLED 0.83 ± 0.78 versus 0.64 ± 0.78) (p < 0.001), and women more often received anticoagulation therapy (94.1% versus 87.6%; p = 0.001). Rhythm control strategies proved significantly less frequent in women (55.8% versus 66.6%; p = 0.001), with a lesser electrical cardioversion (ECV) rate (18.4% versus 27.3%; p = 0.002). Perceived health status was poorer in women. Women were older and presented greater comorbidity than men, with a greater thromboembolic and bleeding risk. Likewise, rhythm control strategies were less frequent than in men, despite the fact that women had poorer perceived quality of life and were more symptomatic.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 98%

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Differences in the Clinical Profile and Management of Atrial Fibrillation According to Gender. Results of the REgistro GallEgo Intercéntrico de Fibrilación Auricular (REGUEIFA) Trial

Durán-Bobin

Elices-Teja

González‐Melchor

et al. 2021

JCM

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“…Various forms of “more sustained AF” (i.e., non-paroxysmal AF, permanent AF, AF progression of paroxysmal to non-paroxysmal AF, and persistent to permanent AF) have been compared with forms of “less sustained AF.” However, results across studies have been inconsistent. For example, one study reported that among patients diagnosed with AF, those with and without diabetes have significant differences in AF types [ 13 ], while another study found no differences [ 16 ]. A study including patients with paroxysmal AF reported an association between diabetes and the development of permanent AF [ 14 ], yet another study found no association [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Association of diabetes with atrial fibrillation types: a systematic review and meta-analysis

Alijla

Buttia

Reichlin

et al. 2021

Cardiovasc Diabetol

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Background Atrial fibrillation (AF) is a common arrhythmia classified as paroxysmal and non-paroxysmal. Non-paroxysmal AF is associated with an increased risk of complications. Diabetes contributes to AF initiation, yet its role in AF maintenance is unclear. We conducted a systematic review and meta-analysis to summarize the evidence regarding the association of diabetes with AF types. Methods We searched 5 databases for observational studies investigating the association of diabetes with the likelihood of an AF type (vs another type) in humans. Study quality was evaluated using the Newcastle–Ottawa Scale. Studies classifying AF types as paroxysmal (reference) and non-paroxysmal were pooled in a meta-analysis using random effects models. Results Of 1997 articles we identified, 20 were included in our systematic review. The population sample size ranged from 64 to 9816 participants with mean age ranging from 40 to 75 years and percentage of women from 24.8 to 100%. The quality of studies varied from poor (60%) to fair (5%) to good (35%). In the systematic review, 8 studies among patients with AF investigated the cross-sectional association of diabetes with non-paroxysmal AF (vs paroxysmal) of which 6 showed a positive association and 2 showed no association. Fourteen studies investigated the longitudinal association of diabetes with “more sustained” AF types (vs “less sustained”) of which 2 showed a positive association and 12 showed no association. In the meta-analysis of cross-sectional studies, patients with AF and diabetes were 1.31-times more likely to have non-paroxysmal AF than those without diabetes [8 studies; pooled OR (95% CI), 1.31 (1.13–1.51), I2 = 82.6%]. The meta-analysis of longitudinal studies showed that for patients with paroxysmal AF, diabetes is associated with 1.32-times increased likelihood of progression to non-paroxysmal AF [five studies; pooled OR (95% CI), 1.32 (1.07–1.62); I2 = 0%]. Conclusions Our findings suggest that diabetes is associated with an increased likelihood of non-paroxysmal AF rather than paroxysmal AF. However, further high quality studies are needed to replicate these findings, adjust for potential confounders, elucidate mechanisms linking diabetes to non-paroxysmal AF, and assess the impact of antidiabetic medications on AF types. These strategies could eventually help decrease the risk of non-paroxysmal AF among patients with diabetes.

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Prevalence and risk of inappropriate dosing of direct oral anticoagulants in two Swiss atrial fibrillation registries

Montrasio

Reiner

Wiencierz

et al. 2022

Vascular Pharmacology

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Prevalence and predictors of atrial fibrillation type among individuals with recent onset of atrial fibrillation

Cited by 9 publications

References 1 publication

Differences in the Clinical Profile and Management of Atrial Fibrillation According to Gender. Results of the REgistro GallEgo Intercéntrico de Fibrilación Auricular (REGUEIFA) Trial

Differences in the Clinical Profile and Management of Atrial Fibrillation According to Gender. Results of the REgistro GallEgo Intercéntrico de Fibrilación Auricular (REGUEIFA) Trial

Association of diabetes with atrial fibrillation types: a systematic review and meta-analysis

Prevalence and risk of inappropriate dosing of direct oral anticoagulants in two Swiss atrial fibrillation registries

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