Prevalence and Predictors of Sleep Disturbance among Liver Diseases in Long-Term Transplant Survivors

Bhat, Mamatha; Wyse, Jonathan; Moodie, Erica E. M.; Ghali, Peter; Hilzenrat, Nir; Wong, Philip; Deschênes, Marc

doi:10.1155/2015/359640

Cited by 13 publications

(10 citation statements)

References 44 publications

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“…The findings suggest that sleep disturbance is a highly prevalent symptom experienced after liver transplantation. The mean total sleep time reported by the participants was 6.01 hours (SD = 1.50), which is less than in previous studies on liver transplant recipients (6.6-7.0 hours; Bhat et al, 2015;Mendes et al, 2014;Reilly-Spong et al, 2013).…”

Section: Sleep Qualitycontrasting

confidence: 64%

Sleep Quality and Related Factors Among Liver Transplant Recipients in Korea: A Cross-Sectional Study

Lim

Choi²,

Kim

et al. 2023

Journal of Nursing Research

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Background Poor sleep quality is common after liver transplantation, which lowers health-related quality of life. However, the detection and management of sleeping difficulties in liver transplant recipients have been limited. Purpose This study was designed to assess sleep quality in liver transplant recipients in Korea and associated factors, including symptom experience, depression, and family support, using the theory of unpleasant symptoms as a theoretical framework. Methods This cross-sectional study of 149 liver transplant recipients in a Korean tertiary hospital was conducted in 2019. Data were obtained using several structured self-report questionnaires, including the Pittsburgh Sleep Quality Index, Modified Transplant Symptom Occurrence and Symptom Distress Scale, Center for Epidemiologic Studies Depression Scale-Revised, and Family Support Scale. Multiple linear regression was used to determine the factors associated with sleep quality. Results The prevalence of sleep disturbance was 55% in the sample. Low sleep quality was associated with being female and with having a higher symptom experience, higher depressive symptoms, and lower family support. In the multiple linear regression analysis, depression and symptom experience was shown to significantly affect sleep quality. Conclusions/Implications for Practice The liver transplant recipients in this study reported poor sleep quality. The factors associated with the sleep quality included depression and symptom experience. To enhance sleep quality, interventions designed to reduce depression and symptoms related to liver transplantation should be provided. The results of this study may be used to develop nursing strategies to improve sleep quality in liver transplant recipients.

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Section: Sleep Qualitycontrasting

confidence: 64%

Sleep Quality and Related Factors Among Liver Transplant Recipients in Korea: A Cross-Sectional Study

Lim

Choi²,

Kim

et al. 2023

Journal of Nursing Research

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“…On the other hand, patients with liver disease and cirrhosis show perturbed sleep and daily rhythm of body temperature ( 105 , 106 ). Decreased testosterone and GH levels as well as sleep problems caused by NAFLD are improved after liver transplantation, suggesting that the liver could play a role in these endocrine and circadian perturbations ( 107 – 109 ). However, inactivating Bmal1 only in hepatocytes has no impact on the circadian rhythm of the animals ( 11 ) and is not sufficient to drive the endocrine perturbations observed in animals with a global deletion of Bmal1 ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease

Jouffe

Weger

Martín

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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Significance While increasing evidence associates the disruption of circadian rhythms with pathologic conditions, including obesity, type 2 diabetes, and nonalcoholic fatty liver diseases (NAFLD), the involved mechanisms are still poorly described. Here, we show that, in both humans and mice, the pathogenesis of NAFLD is associated with the disruption of the circadian clock combined with perturbations of the growth hormone and sex hormone pathways. However, while this condition protects mice from the development of fibrosis and insulin resistance, it correlates with increased fibrosis in humans. This suggests that the perturbation of the circadian clock and its associated disruption of the growth hormone and sex hormone pathways are critical for the pathogenesis of metabolic and liver diseases.

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“…It was worth noting that 50.0% of recipients had excessive urination at night, about half of the recipients woke up in the middle of the night or early in the morning, and over one-third took more than 30 minutes to fall asleep. Recent studies have confirmed that waking up in the middle of the night, nocturia (excessive urination at night), and difficulty falling asleep were common issues for liver transplant recipients [4,28], but the causes and details of these symptoms have not been studied. In addition, it should be emphasized that only 10.48% of patients reported the use of hypnotic medication in the past month, which is less than that reported by Rodrigue (62.1%) [4].…”

Section: Discussionmentioning

confidence: 99%

Sleep Quality and Psychosocial Factors in Liver Transplant Recipients at an Outpatient Follow-Up Clinic in China

et al. 2020

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Background:Sleep disturbance is a common problem in liver transplant recipients, but few studies have confirmed the psychosocial factors associated with sleep quality in patients after liver transplantation. This study aimed to identify the psychosocial factors related to sleep quality among liver transplant patients during outpatient follow-up. Material/Methods:A retrospective cross-sectional study was performed in 124 liver transplant patients during outpatient followup. All participants completed a general demographic questionnaire, the Pittsburgh Sleep Quality Index (PSQI), the Generalized Anxiety Disorder-7 scale (GAD-7), the Patient Health Questionnaire-9 (PHQ-9), and the perceived social support scale (PSSS). Results:The mean global PSQI score was 6.57 (SD, 4.28), which was significantly higher than the mean score for people with normal sleep quality; 50 (40.3%) recipients were classified as having poor sleep quality (PSQI >7). Among the self-reported sleep problems, 62 (50.0%) participants reported that they had to go to the bathroom at night, 58 (43.5%) woke up in the middle of the night or early morning, 84 (67.7%) reported depression symptoms, and 116 (93.5%) had low-level social support. The global PSQI score was positively correlated with anxiety and depression scores, while the global PSSS score was negatively correlated with anxiety and depression scores (p<0.01). Multiple linear regression analysis showed that the length of the post-liver transplant period, the type of residence, BMI, depressive symptoms, and anxiety symptoms were important factors affecting sleep quality among liver transplant patients (p<0.05). Conclusions:Our findings showed high prevalence and incidence of poor sleep quality in liver transplant recipients in outpatient follow-up, with significant correlations with anxiety, depression, and social support, and it was affected by multiple factors. This indicates a need for further research on the follow-up results of sleep and the benefits of comprehensive interventions involving psychosocial factors in liver transplant recipients in China.

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Prevalence and Predictors of Sleep Disturbance among Liver Diseases in Long-Term Transplant Survivors

Cited by 13 publications

References 44 publications

Sleep Quality and Related Factors Among Liver Transplant Recipients in Korea: A Cross-Sectional Study

Sleep Quality and Related Factors Among Liver Transplant Recipients in Korea: A Cross-Sectional Study

Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease

Sleep Quality and Psychosocial Factors in Liver Transplant Recipients at an Outpatient Follow-Up Clinic in China

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