Prevalence and predictors of slow flow in angiographically normal coronary arteries

Arbel, Yaron; Rind, Efrat; Banai, Shmuel; Halkin, Amir; Berliner, Shlomo; Herz, Itzhak; Mashav, Noa; Thurm, Tamar; Keren, Gad; Finkelstein, Ariel

doi:10.3233/ch-2012-1538

Cited by 39 publications

(36 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, several studies have shown that statins are effective in the treatment of patients with SCF [7,8]. However, we did not find them to be protective in the slow flow group [2].…”

Section: Scf Risk Factorscontrasting

confidence: 78%

See 1 more Smart Citation

Lack of correlation between coronary blood flow and carotid intima media thickness

Arbel

Szekely

Berliner

et al. 2014

Clinical Hemorheology and Microcirculation

Self Cite

View full text Add to dashboard Cite

BACKGROUND: The phenomenon of slow coronary flow (SCF) in the presence of normal coronary arteries may indicate endothelial dysfunction, which is characteristic of an early stage in the development of atherosclerosis. Measurement of the Carotid Intima-Media Thickness (CIMT) allows identification of early stages of atherosclerosis. CIMT might offer a non-invasive method of diagnosing SCF patients. Previous studies demonstrated conflicting results regarding the relationship between these two phenomena. In the present study, we examined the association between coronary flow velocity and the degree of CIMT in patients with angiographically normal coronary arteries. METHODS: Coronary arterial blood flow velocity was measured using two methods -Corrected Thrombolysis in Myocardial Infarction (TIMI) Frame Count (CTFC) and Coronary Clearance Frame Count (CCFC). In addition, we measured the level of the CIMT using a special automated computerized software. RESULTS: Seventy Five consecutive patients were prospectively recruited. No correlation was found between CIMT and mean CTFC (r = −0.08, p = NS) or mean CCFC (r = −0.07, p = NS). In addition, CIMT values did not differ between the SCF and the Normal coronary flow (NCF) groups (0.796 mm vs. 0.805 mm, respectively, p = 0.733). Patients with SCF had higher levels of hematocrit (39.9% vs. 36.1%, p < 0.001), LDL cholesterol (101.1 mg/dl vs. 85.8 mg/dl, p = 0.01) and higher rate of current smokers (28.9% vs. 10.8%, p = 0.05). CONCLUSIONS: Patients with angiographically normal coronary arteries and SCF do not have increased CIMT values. However, current smoking, higher LDL cholesterol and hematocrit levels are all related to slower coronary blood flow.

show abstract

“…Moreover, several studies have shown that statins are effective in the treatment of patients with SCF [7,8]. However, we did not find them to be protective in the slow flow group [2].…”

Section: Scf Risk Factorscontrasting

confidence: 78%

“…All patients signed a written informed consent for participation in the current study which was approved by the local institutional ethics committee [1][2][3]31]. …”

Section: Study Design and Patients Selectionmentioning

confidence: 99%

Lack of correlation between coronary blood flow and carotid intima media thickness

Arbel

Szekely

Berliner

et al. 2014

Clinical Hemorheology and Microcirculation

Self Cite

View full text Add to dashboard Cite

show abstract

“…Arbel and colleagues demonstrate that current smoking is the most strong predictor for CSF. 27 Especially smoking might effect the level of HDL-c and proportional lipid parameters.…”

Section: Discussionmentioning

confidence: 99%

Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon

Kalaycı¹,

Suleyman²,

Köktürk³

2019

Turkiye Klinikleri J Cardiovasc Sci

View full text Add to dashboard Cite

A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The association between serum lipid parameters and coronary slow-flow (CSF) phenomenon has been searched previously. The aim of our study was to determine the association between proportional serum lipid parameters and CSF. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : We enrolled 93 stable patients randomly who had undergone coronary angiography and had near-normal coronary arteries with normal and slow coronary flow. Demographic, clinical and laboratory data were recorded retrospectively. Coronary flow velocity was evaluated by TIMI frame count (TFC). CFS phenomenon was defined as a TFC greater than 27 frames. Corrected TFC was calculated for the left anterior descending coronary artery. R Re es su ul lt ts s: : Fifty four patients were in CSF group and 39 patients were in control group. The mean age of the patients in CSF group was significantly higher than control group (55.4±9.5 vs. 50.5±9.8 years, p= 0.019). Triglyceride (TG) levels was found higher in CSF group than control group (187.3±103.4 mg/dl, 125.3±63.8 mg/dl, p<0.001). Total cholesterol to high density lipoprotein cholesterol ratio (TC/HDL-c), TG/HDL-c, low density lipoprotein cholesterol to HDL-c ratio (LDL-c/HDL-c) and non-HDL-c levels were significantly higher in CSF group (p=0.007, p=0.004, p=0.044, p=0.018, respectively). TG and TG/HDL-c were found correlated with TFC (r=0.280, r=0.262, respectively). In multivariate logistic regression analysis age, smoking and TG were found statistically significant to predict of CSF. TG was found most associated with the presence of CSF (OR: 7.516, p=0.001). C Co on nc cl lu us si io on n: : Higher TG, TC/HDL-c, TG/HDL-c, LDLc/HDL-c and non-HDL-c levels were related with CSF phenomenon. K Ke ey yw wo or rd ds s: : Dyslipidemia; HDL-triglyceride; triglycerides; coronary slow flow; lipid ratio Ö ÖZ ZE ET T A Am ma aç ç: : Serum lipid parametreleri ve koroner yavaş akım (KYA) fenomeni arasındaki ilişki daha önce araştırılmıştır. Bizim çalışmamızın amacı oransal lipid parametreleri ile KYA arasındaki ilişkiyi araştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Biz çalışmaya koroner anjiyografi yapılan ve normale yakın koroner arterleri olan, normal ve yavaş koroner akıma sahip 93 stabil hastayı randomize dahil ettik. Demografik, klinik ve laboratuvar verileri retrospektif olarak yerel veri tabanından bulunarak kaydedildi. Koroner akım velositesi miyokard infarktüsünde tromboliz kare sayısı (TFC) ile değerlendirildi. KYA fenomeni TFC'nin 27 kare üzerinde olması olarak tanımlandı. Sol ön inen koroner arter için düzeltilmiş TFC hesaplandı. B Bu ul lg gu ul la ar r: : KYA grubunda 54 hasta, kontrol grubunda 39 hasta vardı. KYA gubunda ortalama yaş, kontrol grubuna göre anlamlı olarak daha fazla saptandı (55,4±9,5 yıl, 50,5±9,8 yıl, p=0,019). Trigliserit (TG) seviyesi KYA grubunda kontrol grubuna göre yüksek bulundu (187,3±103,4 mg/dl, 125,3±63,8 mg/dl, p<0,001). Total kolestrolün yüksek yoğunluklu lipoprotein kolestrolüne oranı ...

show abstract

“…In a study conducted in the Iranian population with CSF phenomenon, 75% of the patients presented with ACS which is different from our study where CSA is more common. The most common presentation of CSF phenomenon was nonspecific chest pain (71.9%) followed by ACS (18.4%) and chronic stable angina (8.8%) in a study conducted by Yaron et al 11 in an Israeli population. LAD artery is the most common coronary artery involved (n = 50), followed by LCX (n = 16) and right coronary artery (RCA) (n = 34) which is similarly reported in other study populations.…”

Section: Discussionmentioning

confidence: 95%

Predictors of Coronary Slow Flow Phenomenon: A Retrospective Study

Rao

Garre

2019

Ind J Car Dis Wom

View full text Add to dashboard Cite

Aim This study aimed to analyze laboratory predictors, angiographic profile, clinical profile, and risk factors for coronary slow flow (CSF) phenomenon without coronary obstructive lesion in patients who came for a coronary angiogram. Materials and Methods The case-control study consisted of patients who underwent coronary angiography and were divided into two groups: patients with coronary slow flow (case group, n = 100) and patients with the normal coronary flow (control group, n = 100). Coronary flow was studied using corrected thrombolysis in myocardial infarction frame count (CTFC). The slow flow was defined as CTFC beyond 2 standard deviations from the normal published range. Risk factors including age, sex, diabetes mellitus (DM), hypertension, dyslipidemia, smoking, body mass index (BMI), hematological and biochemical parameters (complete blood picture, platelet count, total and differential leucocyte count, platelet-to-lymphocyte ratio [PLR], neutrophil-to-lymphocyte ratio [NLR] and lipid profile) were assessed. In both groups, clinical information was collected, and laboratory parameters were measured and compared. Results Patients with CSF were more likely to be male and active smokers. Total cholesterol, triglyceride, BMI, and DM were more commonly seen in the CSF group compared with the control group. Inflammatory markers like uric acid (p = 0.03) and high-sensitivity C-reactive protein (Hs-CRP) (p = 0.000) were found to be statistically significant. Hematocrit (p = 0.023), NLR (p = 0.001), total cholesterol (p = 0.000), triglycerides (p = 0.000), and BMI (p = 0.000) were statistically significant. PLR has the tendency of statistically significance (p = 0.059) BMI, total cholesterol, triglycerides, and Hs-CRP were strong predictors for CSF. Conclusion CSF was common in males, smokers, DM patients, and it was associated with high NLR, uric acid, and Hs-CRP levels. The independent predictor of CSF was BMI, total cholesterol, triglycerides, and Hs-CRP levels. These findings provide an impetus for additional studies to confirm the role of other inflammatory markers in CSF patients and treatment strategies depending on that.

show abstract

Prevalence and predictors of slow flow in angiographically normal coronary arteries

Cited by 39 publications

References 0 publications

Lack of correlation between coronary blood flow and carotid intima media thickness

Lack of correlation between coronary blood flow and carotid intima media thickness

Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon

Predictors of Coronary Slow Flow Phenomenon: A Retrospective Study

Contact Info

Product

Resources

About