Prevalence and Psychological Impact of Acne Vulgaris in Female Undergraduate Medical Students of Rawalpindi and Islamabad, Pakistan

Babar, Osama; Mobeen, Amen

doi:10.7759/cureus.5722

Cited by 17 publications

(30 citation statements)

References 18 publications

(27 reference statements)

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“…This may embarrass the affected individual, lower their self-esteem and the overall quality of life, and in worst cases, lead to depression. In adolescents, the prevalence of acne ranges from about 40% to 90% [ 3 , 4 ], and less than 1% to 22% in the general population [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Elucidating the immune infiltration in acne and its comparison with rosacea by integrated bioinformatics analysis

et al. 2021

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Background Acne vulgaris and rosacea are common inflammatory complications of the skin, both characterized by abnormal infiltration of immune cells. The two diseases can be differentiated based on characteristic profile of the immune cell infiltrates at the periphery of disease lesions. In addition, dysregulated infiltration of immune cells not only occur in the acne lesions but also in non-lesional areas of patients with the disease, thus characterizing the immune infiltration in these sites can further enhance our understanding on the pathogenesis of acne. Methods Five microarray data-sets (GSE108110, GSE53795, GSE65914, GSE14905 and GSE78097) were downloaded from Gene Expression Omnibus. After removing the batch effects and normalizing the data, we applied the CIBERSORT algorithm combined with signature matrix LM22, to describe 22 types of immune cells’ infiltration in acne less than 48 hour (H) old, in comparation with non-lesional skin of acne patients, healthy skin and rosacea (including erythematotelangiectatic rosacea, papulopustular rosacea and phymatous rosacea) and we compared gene expression of Th1 and Th17-related molecules in acne, rosacea and healthy control. Results Compared with the non-lesional skin of acne patients, healthy individuals and rosacea patients, there is a significant increase in infiltration of neutrophils, monocytes and activated mast cells around the acne lesions, less than 48 H after their development. Contrarily, few naive CD4+ T cells, plasma cells, memory B cells and resting mast cells infiltrate acne sites compared to the aforementioned groups of individuals. Moreover, the infiltration of Regulatory T cells (Tregs) in acne lesions is substantially lower, relative to non-lesional sites of acne patients and skin of healthy individuals. In addition, non-lesional sites of acne patients exhibit lower infiltration of activated memory CD4+ T cells, plasma cells, memory B cells, M0 macrophages, neutrophils, resting mast cells but higher infiltration of Tregs and resting dendritic cells relative to skin of healthy individuals. Intriguingly, we found that among the 3 rosacea subtypes, the immune infiltration profile of papulopustular rosacea is the closest to that of acne lesions. In addition, through gene expression analysis of acne, rosacea and skin tissues of healthy individuals, we found a higher infiltration of Th1 and Th17 cells in acne lesions, relative to non-lesional skin areas of acne patients. Conclusions Our study provides new insights into the inflammatory pathogenesis of acne, and the difference between acne and rosacea, which helps in differentiating the two diseases. Our findings also guide on appropriate target therapy of the immune cell infiltrates in the two disease conditions.

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Section: Introductionmentioning

confidence: 99%

Elucidating the immune infiltration in acne and its comparison with rosacea by integrated bioinformatics analysis

et al. 2021

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“…Other research has indicated that people with acne have difficulties in emotion regulation [ 14 ]. Furthermore, greater acne severity is significantly associated with lower quality of life and social functioning [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…In women, skin lesions appear most often on the face, which may significantly impact patients’ well-being [ 2 , 3 , 4 , 5 ]. Among female medical students, approximately 61% complained that their acne treatment was a problem, and almost 90% reported that acne impacts their psychosocial functioning [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Satisfaction with Life and Personality Types A and D in Young Women with Acne Vulgaris

Chilicka

Rogowska

Szyguła

et al. 2020

IJERPH

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People with acne vulgaris report a lower level of satisfaction with life and are more frequently classified as having Type D personalities than those without acne. This research examined, for the first time, the moderating and mediating role of personality type in the relationship between acne severity and satisfaction with life. Among 300 female nursing and cosmetology students ranging in age from 19 to 24 years (M = 21.28, SD = 1.39), 150 individuals (50%) presented with symptoms of acne vulgaris (AV group), while the other 150 (50%) were categorized as controls without acne vulgaris (WAV sample). A cross-sectional study was conducted using three self-report questionnaires: The Satisfaction with Life Scale (SWLS), the Framingham Type A Scale (FTAS), and the Type D Scale (DS14). Acne vulgaris was clinically diagnosed using the Hellgren–Vincent Scale (HVS). The AV group scored significantly higher on the FTAS and DS14 and lower on the SWLS than the WAV sample. Life satisfaction correlated negatively with both the negative affectivity (NA) and social inhibition (SI) subscales of the DS14. The moderating role of the Type A behavioral pattern (TABP) and the mediating role of both NA and SI subscales of the DS14 were observed in the relationship between acne severity and satisfaction with life. The type of personality may explain the mechanism of the relationship between acne disease and subjective well-being. Therefore, psychological interventions and strategies focused on managing stress and mood may effectively improve satisfaction with life in people with acne.

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“…Acne vulgaris (often called acne) is one of the most common in ammatory cutaneous disorders among adolescents and young adults which affects the pilosebaceous unit(1), and could lead to depression, low self-esteem and have adverse in uences on quality of life. In adolescents, it is estimated that the incidence of acne ranges from about 40-90% (2,3). The incidence of acne has been estimated to be 9.4% by the Global Burden of Disease project, ranking it as the eighth most frequent disease worldwide (4).…”

Section: Introductionmentioning

confidence: 99%

Elucidating the Key Biomarkers and Immune Infiltration in Acne by Integrated Bioinformatics Analysis

Yang

Shou

Yang

et al. 2021

Preprint

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Background Acne vulgaris is a common inflammatory condition of skin. However, the landscape of immune infiltration in acne has not been entirely described. Objectives This study used a bioinformatics approach to investigate the inflammatory acne-related key biomarkers and signaling pathways, and immune infiltration in the acne lesion. Methods Two microarray datasets (GSE108110 and GSE53795) were downloaded from Gene Expression Omnibus. We used “limma” package from R software to identify the differentially expressed genes (DEGs) and perform the functional enrichment analyses. Then we built a protein-protein interaction network (PPI), performed the hub genes’ identification through STRING and Cytoscape. We applied the CIBERSORT algorithm to describe the immune infiltration in acne, and explored the correlation between biomarkers and immune infiltration. In the end, our findings in the study were verified by analyzing microarray dataset GSE6475. Results The differentially expressed genes (DEGs) including 292 upregulated genes and 150 downregulated genes in acne compared with non-lesional skin. The hub genes FPR1, C3AR1, CXCL1, CXCL8, FPR2, C3, CCR7, ITGB2 and pivotal pathways JAK-STAT signaling pathway, Toll-like receptor and NOD-like receptor signaling pathway were the most significantly associated with raising neutrophils, monocytes, activated mast cells, as well as reducing resting mast cells and Tregs. Conclusions Our study provides new insights into the pathogenesis and the targets which might be immunomodulatory potential for acne.

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Prevalence and Psychological Impact of Acne Vulgaris in Female Undergraduate Medical Students of Rawalpindi and Islamabad, Pakistan

Cited by 17 publications

References 18 publications

Elucidating the immune infiltration in acne and its comparison with rosacea by integrated bioinformatics analysis

Elucidating the immune infiltration in acne and its comparison with rosacea by integrated bioinformatics analysis

Association between Satisfaction with Life and Personality Types A and D in Young Women with Acne Vulgaris

Elucidating the Key Biomarkers and Immune Infiltration in Acne by Integrated Bioinformatics Analysis

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