Prevalence and risk factors for cervical neoplasia: a cervical cancer screening program in Beijing

Abstract

BackgroundCervical cancer is the second most common cancer and cause of cancer-related death for women worldwide. The aims of this study were to investigate the prevalence of cervical neoplasia and examine factors associated with high-grade cervical squamous intraepithelial lesions (HSIL) among women taking part in a cervical cancer screening program in Beijing.MethodsWomen aged 25–65 years were screened using the ThinPrep cytologic test and gynecologic examination. Univariate and multivariate logistic regressions were conducted to investigate factors associated with HSIL.ResultsAmong 728,704 women screened, the prevalence of cervical intraepithelial neoplasia (CIN) I, II, III was 50.2, 34.0, and 36.4 per 100,000, respectively. Prevalence of cervical cancer was 12.2 per 100,000. Risk factors for HSIL included being in age group of 46–55 years (adjusted odds ratio [aOR] = 1.15, 95% CI: 1.07–1.44, compared with the 25–35 age group), bleeding after intercourse (aOR = 2.08, 95% CI: 1.40–3.10), and presence of trichomonas vaginalis infection (aOR = 2.62, 95% CI: 1.35–5.07), cervical inflammation (aOR = 4.22, 95% CI: 3.39–5.26), and genital warts (aOR = 3.89, 95% CI: 2.54–7.70). High education level (college and above compared with junior middle school or lower) was found to be protective (aOR = 0.79, 95% CI: 0.37–0.90).ConclusionsThe prevalence of cervical neoplasia is relatively high in Beijing. Women aged 46–55 years, those with a lower education level, those reporting bleeding after intercourse, and those affected by Trichomonas vaginalis infection, cervical inflammation and genital warts are at higher risk for HSIL. Particular efforts should be made to ensure these women are included in cervical cancer screening programs.

Prevalence of Cervical Cancer and Associated Risk Factors among Women Attending Cervical Cancer Screening and Diagnosis Center at Yirgalem General Hospital, Southern Ethiopia

“…The finding of this study reveals that multiple sexual partners are significantly associated with cervical cancer as compared to those women who have no exposure of multiple sexual partners (AOR=40; 95% CI: 22.44,70.204) and having history of STI exposure and being HIV positive became significant with the outcome variable of the study as compared to those women who have no history of STI exposure and HIV negative (AOR=8.3 :95%CI: 5.639,12.405) and (AOR=9:95% CI: 9:4.537,17.985) respectively. This is similar with the study that has been conducted on cervical cancer screening program in Beijing [32]. A study in Zambia among HIV infected women states that HIV positive women have higher likelihood of having high grade cervical squamous intra epithelial lesion (AOR=8.0 :95% CI: 20.54,52.04) and cervical cancer cases are reported to occur in more in the immune suppressed cases [4].…”

Prevalência de infecção cervical por papilomavírus humano e neoplasia intraepitelial cervical em mulheres HIV-positivas e negativas

“…Também utilizando resultados de citologia oncótica, recente estudo chinês encontrou prevalência de 0,12% de lesões precursoras do câncer cervical em 728.704 mulheres 13 . Estudo randomizado com 41.955 mulheres com mais de 25 anos encontrou prevalência de alteração na citologia oncótica de 6%, que poderia ser decorrente de células escamosas atípicas de significado indeterminado (ASCUS) ou HSIL.…”

Study of p53 expression in premalignant squamous epithelial lesions of cervix

“…Majority 87.17% of the patients in our study were from the rural area, but this is in contrast to the China Cancer Registration Annual Report 2004, in which 43 cancer registries were included, the incidence of cervical cancer was 5.3 per 100,000 in urban and 4.9 per 100,000 in rural areas. 11 Similar to the present study, the incidence of high-grade lesion for cervical cancer was found to be high among the rural population and they were susceptible to develop the cancer as shown in the study by Parimala A et al 12 High education level (college and above compared with junior middle school or lower) was found to be protective for HSIL (aOR = 0.79, 95% CI: 0.37-0.90) in the study by Lixin Tao et al 13 60% of the women were house wives in the study done by Niveditha VS et al while in the present study, 87.7% were house wives.…”