Prevalence and risk factors for canine epilepsy of unknown origin in the UK

Kearsley‐Fleet, Lianne; O'Neill, D G; Volk, Holger A.; Church, David; Brodbelt, David

doi:10.1136/vr.101133

Cited by 178 publications

(173 citation statements)

References 18 publications

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“…Previous studies have reported the incidence of epilepsy as 0.55–2% of all the dogs referred to veterinary hospitals 34, 35, 36. Our study demonstrated that 10% of dogs with TBI develop PTE.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Early Magnetic Resonance Imaging in Dogs after Traumatic Brain Injury: 50 Cases

Beltrán

Platt

McConnell

et al. 2014

Veterinary Internal Medicne

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BackgroundThe prognostic value of early magnetic resonance imaging (MRI) in dogs after traumatic brain injury (TBI) remains unclear.ObjectivesDetermine whether MRI findings are associated with prognosis after TBI in dogs.AnimalsFifty client‐owned dogs.MethodsRetrospective study of dogs with TBI that underwent 1.5T MRI within 14 days after head trauma. MRI evaluators were blinded to the clinical presentation, and all images were scored based on an MRI grading system (Grade I [normal brain parenchyma] to Grade VI [bilateral lesions affecting the brainstem with or without any lesions of lesser grade]). Skull fractures, percentage of intraparenchymal lesions, degree of midline shift, and type of brain herniation were evaluated. MGCS was assessed at presentation. The presence of seizures was recorded. Outcome was assessed at 48 h (alive or dead) and at 3, 6, 12, and 24 months after TBI.ResultsSixty‐six percent of the dogs had abnormal MRI findings. MRI grade was negatively correlated (P < .001) with MGCS. A significant negative correlation of MRI grade, degree of midline shift, and percentage of intraparenchymal lesions with follow‐up scores was identified. The MGCS was lower in dogs with brain herniation (P = .0191). Follow‐up scores were significantly lower in dogs that had brain herniation or skull fractures. The possibility of having seizures was associated with higher percentage of intraparenchymal lesions (P = 0.0054) and 10% developed PTE.Conclusions and Clinical ImportanceSignificant associations exist between MRI findings and prognosis in dogs with TBI. MRI can help to predict prognosis in dogs with TBI.

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Early Magnetic Resonance Imaging in Dogs after Traumatic Brain Injury: 50 Cases

Beltrán

Platt

McConnell

et al. 2014

Veterinary Internal Medicne

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“…Practice selection required willingness to participate and use of an appropriately configured practice management system (PMS). Clinicians selected summary diagnosis terms at episodes of clinical care from an embedded VeNom Code list (21). Clinical data extraction from PMSs used integrated clinical queries (22) before uploading to a secure structured query language (SQL) database.…”

Section: Methodsmentioning

confidence: 99%

Longevity and mortality of cats attending primary care veterinary practices in England

O’Neill

Church

McGreevy

et al. 2014

Journal of Feline Medicine and Surgery

180

164

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Enhanced knowledge on longevity and mortality in cats should support improved breeding, husbandry, clinical care and disease prevention strategies. The VetCompass research database of primary-care veterinary practice data offers an extensive resource of clinical health information on companion animals in the UK. This study aimed to characterise longevity and mortality in cats and to identify important demographic risk factors for compromised longevity. Crossbred cats were hypothesised to live longer than purebred cats. 3Descriptive statistics were used to characterise the deceased cats. Multivariable linear regression methods investigated risk factor association with longevity in cats that died at or after 5 years of age.From 118,016 cats attending 90 practices in England, 4,009 cats with confirmed deaths were randomly selected for detailed study. Demographic characterisation showed that 3,660 (91.7%) were crossbred, 2,009 (50.7%) were female and 2,599 (64.8%) were neutered. The most frequently attributed causes of mortality in cats of all ages were trauma (12.2%), renal disorder (12.1%), non-specific illness (11.2%), neoplasia (10.8%) and mass lesion disorders (10.2%). Overall, the median longevity was 14.0 years (IQR 9.0-17.0; range 0.0-26.7). Crossbred cats had a higher median longevity than purebred cats (median (IQR) 14.0 years (9.1-17.0) versus 12.5 years (6.1-16.4), P < 0.001) but individual purebred cat breeds varied substantially in longevity. In cats dying at or after 5 years (n = 3,360), being crossbred, lower bodyweight, neutered and non-insured were associated with increased longevity. This study described longevity in cats and identified important causes of mortality and breed-related associations with compromised longevity.

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“…Analysis of this large data resource would allow DMVD prevalence to be estimated and major risk factors for the disease to be identified, as has been demonstrated for other disorders in companion animals 19, 20, 21…”

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confidence: 99%

Prevalence of and Risk Factors for Degenerative Mitral Valve Disease in Dogs Attending Primary‐care Veterinary Practices in England

Mattin

Boswood

Church

et al. 2015

Veterinary Internal Medicne

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BackgroundTo date, epidemiological studies on degenerative mitral valve disease (DMVD) in dogs have largely reported referral caseloads or been limited to predisposed breeds. Analysis of primary‐care data to identify factors associated with DMVD would help clinicians identify high‐risk individuals and improve understanding.ObjectivesTo estimate the prevalence of and identify risk factors for DMVD in dogs attending primary‐care veterinary practices in England.AnimalsCases were identified within the electronic patient records of 111,967 dogs attending 93 practices. Four hundred and 5 dogs were diagnosed with DMVD (diagnosed cases) and a further 3,557 dogs had a heart murmur (HM) consistent with DMVD (possible cases).MethodsRetrospective cross‐sectional study design. Prevalence was adjusted for the sampling approach. Mixed effects logistic regression models identified factors associated with DMVD.ResultsPrevalence estimates of diagnosed DMVD and HMs consistent with DMVD (both diagnosed and possible cases) were 0.36% (95% confidence interval [CI]: 0.29–0.45) and 3.54% (95% CI: 3.26–3.84) respectively. In the multivariable analysis, males had higher odds of diagnosed DMVD than did females (odds ratio [OR] 1.40, 95% CI: 1.12–1.74). Insured dogs had increased odds of DMVD compared with noninsured dogs (OR 3.56, 95% CI: 2.79–4.55) and dogs ≥20 kg had approximately half the odds of DMVD diagnosis compared with dogs <20 kg (OR 0.51, 95% CI: 0.36–0.74). Strong associations between a DMVD diagnosis and individual breeds and age were identified.Conclusions and Clinical ImportanceDegenerative mitral valve disease was a common disorder in practice‐attending dogs. Knowledge of identified risk factors for DMVD could improve clinical diagnosis and direct future research.

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Prevalence and risk factors for canine epilepsy of unknown origin in the UK

Cited by 178 publications

References 18 publications

Prognostic Value of Early Magnetic Resonance Imaging in Dogs after Traumatic Brain Injury: 50 Cases

Prognostic Value of Early Magnetic Resonance Imaging in Dogs after Traumatic Brain Injury: 50 Cases

Longevity and mortality of cats attending primary care veterinary practices in England

Prevalence of and Risk Factors for Degenerative Mitral Valve Disease in Dogs Attending Primary‐care Veterinary Practices in England

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