Prevalence and risk factors for gastroesophageal reflux in pregnancy

Ramu, Bhavadharini; Mohan, Pazhanivel; Rajasekaran, Muthu Subramanian; Venkataraman, Jayanthi

doi:10.1007/s12664-010-0067-3

Cited by 36 publications

(18 citation statements)

References 16 publications

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“…In an earlier study, we had shown that the overall prevalence of GER in pregnancy was 45.5%. 9 In the present study, however, the overall prevalence of GER was higher at 83.4% with the prevalence highest in first trimester and decreasing thereon, similar to that reported by Ho et al 10 from Singapore. Rey et al 4 found the incidence of GER similar across all three trimesters.…”

Section: Discussionsupporting

confidence: 90%

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Gastroesophageal reflux disease in pregnancy: a longitudinal study

RS¹

2014

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Background: Gastroesophageal reflux (GER) symptoms are common in pregnancy. It often manifests for the first time in pregnancy during the first three months and ceases after delivery.Aim: To study the prevalence of gastroesophageal reflux in each of the three trimesters by follow-up of pregnant women. To examine the association between dietary factors and GER in pregnancy Methods: This was a prospective hospital-based study. Sixty four pregnant women in their first trimester attending an antenatal clinic were interviewed for symptoms of GER and for dietary details and followed up until term and delivery.Results: Fifty women (83.4%) experienced either heartburn or regurgitation during pregnancy. GER was commoner in primi-gravida (69.3%) and 50% remained symptomatic until term.Regurgitation was more common than heartburn and was often associated with nausea / vomiting. Women with an antenatal history of GERD had 3.79 times the odds of developing symptoms in the third trimester. There was no difference in weight gain in those with and without GER. Spicy food significantly increased the risk of heartburn and green vegetables were protective. Conclusions: The incidence of GERD decreased over three trimesters. Weight gain did not increase the prevalence of GERD. Spicy food aggravated while green vegetables protected against GERD.KEYWORDS: gastroesophageal reflux disease, pregnancy, diet the first three months of gestation and ceases soon after delivery. 7,8 The origin of GER in pregnancy is multifactorial, but the predominant factor is a decrease in lower esophageal sphincter pressure caused by progesterone. Mechanical factors play a minor role. Serious reflux complications during pregnancy are rare and seldom do these patients need investigation.Our recent cross sectional study found a prevalence of 45.5% GER in pregnancy. 9 There however has been no prospective study from India examining the natural history of

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Section: Discussionsupporting

confidence: 90%

“…Serious reflux complications during pregnancy are rare and seldom do these patients need investigation.Our recent cross sectional study found a prevalence of 45.5% GER in pregnancy. 9 There however has been no prospective study from India examining the natural history of…”

mentioning

confidence: 99%

Gastroesophageal reflux disease in pregnancy: a longitudinal study

RS¹

2014

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“…As we showed, there was a positive correlation between the number of infants exposed to PPIs during the third trimester and the birth weight. Ramu et al described increased gestational age as a risk factor for reflux in pregnancy [24], and birth weight is greater when gestational age at delivery increases.…”

Section: Discussionmentioning

confidence: 99%

The Safety of Fetal Exposure to Proton-Pump Inhibitors During Pregnancy

et al. 2011

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“…Prevalence rates have been estimated to be lower in Asia when compared to that of the western countries (<5% vs. 10% to 20%) [12]. The current articles on GERD in this Journal [13][14][15][16] demonstrate that contrary to previous belief, the prevalence of GERD in India is in fact much higher and similar to that reported in the Western countries. However, it is unclear if this represents a true increase in the prevalence or is the result of a better understanding of the disease symptoms, increased awareness of acid reflux, or the recent conduct of high quality epidemiological studies.…”

Section: Prevalence Of Gerd In Indiamentioning

confidence: 51%