Prevalence and risk factors for oral human papillomavirus infection in 129 women screened for cervical HPV infection

Meyer, Moritz; Huebbers, Christian U.; Siefer, Oliver; Vent, Julia; Engbert, Iris; Eslick, Guy D.; Valter, Markus M.; Klußmann, Jens Peter; Preuss, Simon F.

doi:10.1016/j.oraloncology.2013.10.009

Cited by 41 publications

(41 citation statements)

References 34 publications

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“…2A). Furthermore, we performed a meta-analysis to examine the association between oral sex and HPV infection in females [12, 18, 20, 23], though no statistically significant association was found (OR: 1.08, 95% CI: 0.70 - 1.67, P = 0.71). As for males, Dahlstrom et al reported a high prevalence of oral HPV infection in men who had oral sex experience, though no significant association between oral sex and HPV infection was found.…”

Section: Resultsmentioning

confidence: 99%

Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis

Shigeishi

Sugiyama

2016

J Clin Med Res

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BackgroundOral human papillomavirus (HPV) infection is associated with oral cancer development. However, few epidemiologic investigations have focused on oral HPV prevalence in healthy individuals. The objective of this study was to provide updated information regarding oral HPV prevalence in patients without oral cancer worldwide.MethodsWe systematically reviewed 29 studies reporting the prevalence of oral HPV infection that included 22,756 subjects (10,124 males, 12,623 females, and nine unknown gender; age range 2 - 89 years) and were published from January 2012 to June 2015.ResultsThe prevalence of overall HPV, low-risk type HPV, high-risk type HPV, and HPV16 in the reported cases was 5.5%, 2.2%, 2.7%, and 1.0%, respectively. The prevalence of overall HPV was considerably higher in males who had sex with males (12.2%) as compared to heterosexual males (4.7%) and females (2.9%). A meta-analysis was performed to elucidate significant risk factors for oral HPV infection, which revealed a significant statistical association for oral sex and smoking with oral HPV infection (odds ratio (OR): 1.90, 95% confidence interval (CI): 1.51 - 2.39, P < 0.0001; OR: 2.13, 95% CI: 1.32 - 3.43, P = 0.002).ConclusionsOur findings suggest that sexual behavior and smoking are importantly related to oral HPV infection in healthy individuals.

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Section: Resultsmentioning

confidence: 99%

Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis

Shigeishi

Sugiyama

2016

J Clin Med Res

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“…Nevertheless, although HPV is highly associated with tonsillar cancer [4,11], less than 1% of tumor-free tonsillar tissue harbors HPV DNA [12]. Even in women with genital HPV infections, HPV DNA detection in the oropharynx is low (5.7%) and comparable to HPV DNA detection rates in females negative for genital HPV (5.1%), suggesting that sexual transmission of HPV from the cervix uteri to the oropharynx is rare [13]. However, in a recent study in patients undergoing tonsillectomy for benign indications, the HPV prevalence was 3.6% in tonsil brushings and 13.1% in gargles (with an HPV16 prevalence of 2.2 and 4.1%, respectively), indicating significant differences caused by sampling techniques [14] which may account for inconsistency in this field.…”

Section: Natural Hpv Life Cycle and Oncogene Regulationmentioning

confidence: 99%

Human Papillomavirus-Related Head and Neck Cancer

Wagner¹,

Sharma²,

Wuerdemann³

et al. 2017

Oncol Res Treat

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Human papillomavirus(HPV)-related head and neck cancer is recognized as a distinct tumor entity with rising incidence reported for several countries. These tumors arise from squamous cells, typically in the oropharynx. In contrast to cancer associated with other risk factors, HPV-related cancer is driven by viral oncoprotein activity and has individual profiles regarding protein expression, and genetic and epigenetic alterations. Molecular characteristics are p16^IN4A overexpression, absence of p53 inactivating mutations, and PI3K/AKT and Wnt pathway modulation. Patients with HPV-related head and neck cancer have improved survival compared to those with HPV-negative tumors, and p16^INK4A staining has been introduced into tumor staging recently. However, no specific or toxicity-reduced treatment modalities have been established for this entity so far. Although the still incomplete and partially inconsistent data in this field needs further study, particular features of HPV-related cancers such as specific microRNA expression, immunology, or gene methylation patterns certainly have the potential to be implemented in future diagnostic and therapeutic concepts.

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“…Aucune étude épidémiologique n'a évalué la prévalence de cette infection dans la population burkinabé. Nous pouvons cependant minimiser le rôle de ce virus dans la prédominance féminine des cancers de la cavité buccale puisqu'aucune corrélation entre l'infection génitale au HPV et la colonisation buccale par le même virus n'a encore été démontrée [12].…”

Section: Discussionunclassified

Les cancers de la cavité buccale : affection à prédominance féminine à Ouagadougou

Bambara

Millogo

Konsem

et al. 2015

Med Buccale Chir Buccale

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Résumé -Objectif : Nous avons mené une étude rétrospective dans le but de présenter les caractéristiques des cancers de la cavité buccale à travers une comparaison entre les deux sexes au CHU Yalgado Ouédraogo (Ouagadougou, Burkina Faso). Patients et méthodes : Il s'agit d'une étude rétrospective à partir de l'examen des dossiers de 79 patients reçus en consultation entre janvier 2003 et décembre 2014. Tous les patients avec un diagnostic histologique d'une tumeur maligne intra-orale ont été inclus. Les caractéristiques démographiques des patients (âge, sexe) et les principales caractéristiques des tumeurs malignes (localisation, type histologique) ont été explorées. Les variables ont été comparées selon le sexe à l'aide du test T de Student. Résultats : Nous avons colligé 79 patients âgés en moyenne de 56 ans. La prédominance féminine était nette (sex ratio = 0,55). Les femmes étaient à 90,2 % sans emploi tandis que la proportion d'hommes sans emploi s'élevait à 60,7 % (p = 0,004). Les hommes étaient tous fumeurs alors que la majorité des femmes chiquaient le tabac. Chez les sujets masculins, les cancers de la langue étaient les plus fréquents (32,1 %), suivis des cancers du palais et des cancers de la joue. Chez les femmes, les localisations les plus fréquentes étaient les lèvres (37,3 %), la joue et la gencive. Les hommes ont consulté à des stades plus avancés que les femmes. Le carcinome épidermoïde était prédominant dans les deux sexes. Conclusion : Le bas niveau socio-économique joue probablement un rôle important dans cette prédominance féminine.Abstract -Cancers of the oral cavity: a female-predominant incidence in Ouagadougou. Oral cavity cancers affect men more often than women. A female predominance has been observed in consultation at Yalgado Ouedraogo Teaching Hospital. Objective: We conducted a retrospective study with the aim of showing the characteristics of these cancers through a comparison between the two sexes at Yalgado Ouedraogo Teaching Hospital (Ouagadougou, Burkina Faso). Materials and Methods: A retrospective study from 79 medical files of patients consulting between January 2013 and December 2014 was conducted. All of them were affected by a histological confirmed cancer of the oral cavity. The demographic characteristics of the patients (age and gender) and main characteristics of the malign tumor (localization, histological type) were investigated. Parameters were compared according to gender with the Student t-test. Results: We collected 79 patients with an average age of 56 (standard deviation: 15 years). The female predominance was clear (sex ratio = 0.55) and related to all the age groups. The proportion of patients who had no job was about 90.2% for women versus 60.7% for men (p = 0.004). The men were all smokers, while some women chewed tobacco. Tongue cancer was more frequent in the male subject (32.1%), followed by palate cancer and cheek cancer. Among women, the most frequent localizations were the lips (37.3%), the cheeks and the gum. Men consulted at more advanced stages t...

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Prevalence and risk factors for oral human papillomavirus infection in 129 women screened for cervical HPV infection

Cited by 41 publications

References 34 publications

Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis

Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis

Human Papillomavirus-Related Head and Neck Cancer

Les cancers de la cavité buccale : affection à prédominance féminine à Ouagadougou

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