Prevalence and Risk Factors of Pterygium Occurrence in Population above 50 Years Old in Bali

Djelantik, Anak Agung Ayu Sukartini; Yuliawati, Putu; Naryati, L.P.E

doi:10.15562/bmj.v5i3.342

Cited by 3 publications

(4 citation statements)

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“…One widely accepted hypothesis regarding pterygium pathogenesis is that exposure to the environmental factors, particularly the UV radiation, can activate various signaling pathways that trigger the production of mediators responsible for pterygium growth [1]. At molecular level, the UV radiation is associated with the generation of active free radicals that can damage and deactivate macromolecules.…”

Section: Pterygiummentioning

confidence: 99%

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Untitled

2023

J. Med. Chem. Sci.

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Pterygium is an ocular disease characterized by the growth of fibrovascular tissue and a wing-shaped fold of conjunctiva on the surface of the cornea. The progression of this disease is primarily influenced by exposure to the ultraviolet (UV) light, which induces the production of growth factors, one of which is basic Fibroblast Growth Factor (bFGF), at the chronic inflammation or DNA damage stages, causing pterygium cell invasion. Various surgical techniques serve as the main modalities for this disease, including conjunctival flaps, conjunctival autografts, bare sclera, and the use of amniotic membranes. No specific procedure can completely prevent the recurrence of this disease. The recurrence of this disease at the global level and in Indonesia remains high, ranging from 10-80% and 24-89%, consecutively. A combination of pterygium treatment with adjuvant therapy developed from natural ingredients was developed to resolve this problem. One of the natural ingredients is epigallocatechin-3-gallate (EGCG), which is the extract of green tea. EGCG is acknowledged to have anti-inflammatory, antioxidant, antifibrotic, and antineoplastic effects. EGCG can moderately attenuate pterygium cell proliferation without significantly affecting conjunctival cells. Therapy using EGCG can be applied in various techniques that effectively meet the EGCG needs in the body and treat eye diseases. So far, there have not been many studies on the effect of EGCG administration on pterygium recurrence. For those reasons, it is necessary to conduct a study regarding the effect of the administration of EGCG on the expression of bFGF and apoptosis in Human Pterygium Fibroblast (HPF) compared to the administration of mitomycin C (MMC), which is the commonly used therapy. It is expected that EGCG administration can serve as the best solution for preventing pterygium recurrence in the future.

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Section: Pterygiummentioning

confidence: 99%

“…Pterygium is a common ocular disease [1][2][3]. The global prevalence of the disease ranges from 1.1% to 53%.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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“…Pterigium merupakan kelainan mata berupa munculnya jaringan fibrovaskular yang berasal dari konjungtiva dan tumbuh mengarah ke kornea. 1 Berdasarkan data penelitian sebelumnya, kasus pterigium di Indonesia mencapai angka 8,3% dari total populasi. 2 Dijelaskan lebih rinci bahwa prevalensi kasus lebih tinggi mulai ditemukan pada usia 35 tahun, dan juga lebih tinggi ditemukan pada pekerja tani, nelayan dan buruh.…”

Section: Pendahuluanunclassified

“…Komplikasi tersering akibat pengobatan yang terlambat adalah dapat mengakibatkan gangguan refraksi dan defek permanen pada kornea. [1][2][3] Berbagai teknik operasi relatif telah berkembang, diantaranya adalah bare sclera, conjungtival autograft maupun dengan membrane transplantation. Diantara teknik operasi tersebut, conjungtival autograft menjadi pilihan saat ini.…”

Section: Pendahuluanunclassified

Conjungtival autograft menggunakan fiksasi autologus pada kasus pterigium: laporan kasus

Tanjung

Philips

Magnadi

2022

Intisari Sains Medis

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Background: Pterygium is a growth disorder of fibrovascular tissue from the white part of the eye towards the cornea. Surgery is the main treatment option at this time. Several surgical techniques have been developed and can be performed to treat pterygium cases, one of which is conjunctival autograft. This surgical technique is performed by excising the pterygium tissue and then taking healthy conjunctival tissue to close the excision of the pterygium. Autologous is one way of attaching healthy conjunctival grafts to the site of pterygium excision. This case report aims to evaluate conjunctival autograft using autologous fixation in pterygium cases. Case Description: A 50-year-old woman working as a housewife came to the eye clinic complaining of pain in the patient's left eye accompanied by itching, red eyes, and watering. Complaints have been felt for about 1 week. The patient also complained about the appearance of a white spot that was felt to be getting bigger in his left eye. Ophthalmological examination of the anterior segment of the left eye revealed a reddish-white tissue arising from the conjunctiva through the limbus but not yet reaching the center of the cornea. The patient has been diagnosed with stage 3 pterygium and is planned to perform autologous conjunctival autograft surgery on the patient. Conclusion: Conjunctival autograft surgery using autologous fixation is an option for surgery in pterygium cases. The results obtained after this operation are satisfactory, but the patient is still informed about possible complications or recurrences. Latar Belakang: Pterigium merupakan sebuah kelainan pertumbuhan jaringan fibrovaskular dari bagian putih mata mengarah kearah kornea. Tindakan operasi merupakan pilihan terapi utama saat ini. Beberapa teknik operasi telah berkembang dan dapat dilakukan untuk menangani kasus pterigium, salah satunya adalah conjungtival autograft. Teknik operasi ini dilakukan dengan mengeksisi jaringan pterigium lalu mengambil jaringan konjungtiva yang sehat untuk menutup bekas eksisi pterigium. Autologus merupakan salah satu cara untuk merekatkan cangkuk konjungtiva sehat di tempat eksisi pterigium. Laporan kasus ini bertujuan untuk mengevaluasi conjungtival autograft menggunakan fiksasi autologus pada kasus pterygium. Deskripsi Kasus: Seorang wanita berusia 50 tahun, bekerja sebagai ibu rumah tangga datang ke poliklinik mata dengan keluhan rasa perih di mata kiri pasien dan disertai dengan rasa gatal, mata merah, serta berair. Keluhan dirasakan sejak kurang lebih 1 minggu. Pasien juga mengeluhkan muncul bercak putih yang dirasa makin membesar di mata kirinya. Pemeriksaan oftalmologi segmen anterior mata kiri didapatkan sebuah jaringan berwarna putih kemerahan yang timbul dari arah konjugtiva melewati limbus tetapi belum sampai ke tengah kornea. Pasien didiagnosis dengan pterigium stadium 3 dan direncanakan untuk dilakukan operasi conjungtival autograft dengan autologus kepada pasien tersebut. Kesimpulan: Teknik operasi conjungtival autograft dengan menggunakan fiksasi autologus merupakan salah satu pilihan operasi pada kasus pterigium. Hasil yang didapat setelah operasi ini cukup memuaskan, tetapi pasien tetap diinformasikan tentang kemungkinan komplikasi ataupun kekambuhan yang dapat terjadi.

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