Prevalence and risk factors of obesity, hypertension, dyslipidemia and diabetes mellitus before and after adult living donor liver transplantation

Hara, Yasuyuki; Kawagishi, Naoki; Nakanishi, Waka; Tokodai, Kazuaki; Nakanishi, Chikashi; Miyagi, Shigehito; Ohuchi, Noriaki

doi:10.1111/hepr.12418

Cited by 15 publications

(22 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In transplant recipients, the known incidence of dyslipidemia is 17% to 66%. 18 We reported a dyslipidemia rate of 25% in our study population.…”

Section: Discussionmentioning

confidence: 50%

“…The prevalence of diabetes mellitus in transplant recipients is 30% to 40%, which is consistent with our results. 18 Moreover, attributing factors, such as male sex, HCV infection, and calcineurin inhibitors, were also present in our recipients.…”

Section: Discussionmentioning

confidence: 72%

“…6,18 Tacrolimus was used as an immunosuppressant in most of our liver transplant recipients, which may be the attributing factor to the lower incidence of hypertension. In our study, 32.8% of patients developed diabetes mellitus after liver transplant.…”

Section: Discussionmentioning

confidence: 99%

“…6 These complications, including diabetes mellitus, hypertension, obesity, and malignancy, are mainly attributed to immunosup pression. 18 The prevalence of hypertension is reported to be 60% to 70%, and the effect of a calcineurin inhibitor on renal vasculature is considered a causative factor in liver transplant recipients. 6,18 In our study population, 38.6% of recipients developed hypertension after transplant.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Untitled

Laeeq

Hanif²,

Luck³

et al. 2017

Exp Clin Transplant

View full text Add to dashboard Cite

Objectives: Liver transplant is a definite treatment of decompensated liver disease. Because of the shortage of livers from deceased donors, living-donor liver transplant is becoming more common. Here, we analyzed our clinical experience in the follow-up care of these patients. Conclusions: Hepatitis C-related cirrhosis was the most common indication for liver transplant, and infection recurrence was observed in our patients. Biliary anastomotic stricture formation was the most prevalent complication after transplant. As liver transplants are becoming more widely available for Pakistani patients at home and abroad, gastroenterologists and trainees in our country should be sensitized, educated, and skilled in the posttransplant care of these patients.

show abstract

“…In transplant recipients, the known incidence of dyslipidemia is 17% to 66%. 18 We reported a dyslipidemia rate of 25% in our study population.…”

Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Untitled

Laeeq

Hanif²,

Luck³

et al. 2017

Exp Clin Transplant

View full text Add to dashboard Cite

show abstract

“…Long-term hyperglycemia and metabolic disturbance usually result in damage to multiple organs, including eyes, kidney, nerve, heart and vessels ( 9 , 10 ). However, in DM patients, the risk of cardiovascular complications is equivalent to that of patients with CAD, and, thus, similar treatment methods should be adopted to improve the prognosis of cardiovascular diseases ( 11 , 12 ). DM is usually accompanied with hypertension, which is a key risk factor for cardiovascular complications in DM patients ( 13 , 14 ).…”

Section: Discussionmentioning

confidence: 99%

Correlation between the levels of serum cystatin�C and substance�P in peripheral blood in diabetes mellitus patients complicated with hypertension

Zhu

Gong²,

Luo

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

Correlation between the serum cystatin C and substance P in peripheral blood of diabetes mellitus patients complicated with hypertension was investigated. Diabetes mellitus patients with or without hypertension were selected in No. 215 Hospital of Shaanxi Nuclear Industry from December 2015 to February 2017. There were 60 patients with only hypertension (hypertension control group), 60 patients with only diabetes mellitus (diabetes mellitus control group) and 60 patients with diabetes mellitus combined with hypertension (observation group). Levels of serum cystatin C and substance P in peripheral blood were measured via immunoturbidimetry and enzyme-linked immunosorbent assay, respectively, and the correlation with hypertension was analyzed. The average level of serum cystatin C in the observation group was higher than that of the two control groups (P<0.05). The level of substance P in peripheral blood of the observation group was lower than that of the diabetic control group (P<0.05). The levels of serum cystatin C in patients with grade III hypertension in observation group were higher than those in grades II and I, and the levels of substance P in peripheral blood of patients with grade III hypertension in observation group were lower than those in grades II and I. Systolic pressure of patients in observation group was significantly positively correlated with level of serum cystatin C, but significantly negatively correlated with level of substance P in peripheral blood (P<0.05). Compared with the diabetes mellitus patients, level of serum cystatin C was higher, and level of substance P peripheral blood was lower in diabetes mellitus patients complicated with hypertension. In diabetes mellitus patients, blood pressure was positively correlated with serum cystatin C level, and negatively correlated with substance P level in peripheral blood.

show abstract

Metabolic Complications in Liver Transplantation Recipients: How We Can Optimize Long‐Term Survival

et al. 2021

View full text Add to dashboard Cite

Liver transplantation (LT) recipients have experienced a significant improvement in short-term survival during the past 3 decades attributed to advancements in surgical techniques, perioperative management, and effective immunosuppressive regimens. However, long-term survival is affected by a high incidence of metabolic disorders and their consequences, including cardiovascular disease (CVD) and malignancies. Pretransplant metabolic impairments especially in those with nonalcoholic steatohepatitis cirrhosis are aggravated by the addition of posttransplant weight gain, physical inactivity, and reversal from catabolic to anabolic state. Moreover, although immunosuppressants are vital to avoid graft rejection, long-term exposure to these medications is implicated in metabolic impairments after LT. In this review, we summarize the molecular pathogenesis of different metabolic disorders after LT, including diabetes mellitus, dyslipidemia, and nonalcoholic fatty liver disease. Furthermore, CVD, malignancies, and graft rejections were provided as significant complications of post-LT metabolic conditions threatening both the patient and graft survival. Ultimately, emerging preventive and treatment strategies for posttransplant diabetes mellitus are summarized. This review highlights the significant need for more clinical trials of antihyperglycemic agents in LT recipients. Also, translational studies will help us to better understand the molecular and genetic factors underlying these metabolic complications and could lead to more personalized management in this high-risk population.

show abstract

Prevalence and risk factors of obesity, hypertension, dyslipidemia and diabetes mellitus before and after adult living donor liver transplantation

Abstract: The prevalence of hypertension increased after LTx and pretransplant obesity was associated with several post-transplant metabolic abnormalities.

Cited by 15 publications

References 41 publications

Untitled

Untitled

Correlation between the levels of serum cystatin�C and substance�P in peripheral blood in diabetes mellitus patients complicated with hypertension

Metabolic Complications in Liver Transplantation Recipients: How We Can Optimize Long‐Term Survival

Contact Info

Product

Resources

About