Prevalence and risk factors of posterior vitreous detachment in a Chinese adult population: the Handan eye study

Shen, Zhijun; Duan, Xianbao; Wang, Fenghua; Wang, Ningli; Peng, Yi; Liu, David T.L.; Peng, Xiaoyan; Li, Sizhen; Liang, Yuan Bo

doi:10.1186/1471-2415-13-33

Cited by 19 publications

(22 citation statements)

References 25 publications

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“…The prevalence of a complete PVD increases with age up to 28.1% at age 70-80 years; while prevalence estimates in the literature vary, primarily due to different examination methods, similar age relationships are reported (Weber-Krause & Eckardt 1997;Shen et al 2013). The population-based Handan Eye Study found a prevalence of 2.7% in Chinese subjects at age 30-70 years using funduscopy (Shen et al 2013). Weber- Krause & Eckardt (1997) reported an 11% complete PVD prevalence in 65-69-year-old subjects using kinetic sonography in a German cohort, increasing to over 45% in those over the age of 80 years.…”

Section: Discussionmentioning

confidence: 87%

Characteristics and pathologies of the vitreo‐macular interface—results from the Gutenberg Health Study

Schuster

Kluck

Korb

et al. 2019

Acta Ophthalmologica

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Purpose: We aimed to determine the prevalence of characteristics and pathologies of the vitreo-macular interface within the general population. Methods: The Gutenberg Health Study is a population-based study in Germany, including an ophthalmological examination with refraction, biometry and optical coherence tomography (OCT) imaging. Characteristics of the vitreo-macular interface were graded on volume scans including visibility of an epiretinal membrane, full-thickness macular hole, lamellar hole and pseudohole. Overall and age-specific prevalences including 95% confidence intervals [95%-CI] were calculated. Association analyses were conducted to determine systemic and ocular factors that are associated with epiretinal membranes (the most common pathology) using multivariable logistic regression. Results: A total of 1890 people aged 40-80 years were included in the study. Of these, 4.7% (95%-CI: 3.8%-5.8%) had an epiretinal membrane in at least one eye, 0.1% a full-thickness macular hole, 0.6% a lamellar hole and 0.6% a pseudohole. The presence of an epiretinal membrane was associated with higher age, myopic refractive error and prior retinal laser therapy, but not with gender, body height, body weight, smoking, prior cataract surgery or intraocular pressure. Conclusions: Epiretinal membranes are more frequent in older and myopic subjects and in those with prior retinal laser therapy.

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Section: Discussionmentioning

confidence: 87%

Characteristics and pathologies of the vitreo‐macular interface—results from the Gutenberg Health Study

Schuster

Kluck

Korb

et al. 2019

Acta Ophthalmologica

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“…Other well-known VMI diseases such as macular hole and ERM have also been shown to occur more commonly with aging [16-18] and in women, [19-22] whereas there are inconsistent findings with regards to smoking as a risk factor. [11, 15, 23, 24] The reason that smoking is associated with VMA and VMT in AMD remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

Influence of the Vitreomacular Interface on Treatment Outcomes in the Comparison of Age-Related Macular Degeneration Treatments Trials

et al. 2015

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Objective To assess the association of the vitreomacular interface (VMI) with outcomes of eyes treated with anti-VEGF drugs for neovascular age-related macular degeneration (AMD). Design Prospective cohort study within a multicenter randomized clinical trial. Participants Patients enrolled in the Comparison of AMD Treatments Trials. Methods Treatment was assigned randomly to either ranibizumab or bevacizumab and to 3 different regimens for dosing over a two-year period. Masked readers at a reading center assessed optical coherence tomography (OCT) scans at baseline and follow-up for vitreomacular traction (VMT) and adhesion (VMA), fluid and central thickness. Visual acuity (VA) was measured by masked, certified examiners. Main Outcome Measures VA and anatomical features at baseline, 1 and 2 years and number of treatments. Results At baseline, 143 (12.8%) patient eyes had VMT or VMA. Compared to those with neither (N=972), patients with VMT or VMA were younger (mean (SE): 75.5 ±0.6 versus 79.7 ± 0.24 years, p<0.0001), more likely to be male (52.4% versus 36.2%, p=0.0003), cigarette smokers (68.5% versus 55.3%, p=0.003), and to have subretinal fluid on OCT (86.7% versus 81.0%, p=0.047). VMI status was not associated with VA at baseline or follow-up. Among eyes treated as needed (PRN, n=598) and followed for 2 years (n=516), the mean number of injections over 2 years was 15.4 ±0.9 for eyes having VMT at baseline or during follow-up (n=60), 13.8 ±0.7 for eyes with VMA at baseline or follow-up (n=79), and 12.9 ±0.4 (p=0.02) for eyes without VMT or VMA (n=377). In addition, the mean number of injections in eyes treated PRN increased from 13.0 ±0.3 when VMT was not observed, to 13.6 ±1.3 when observed once, to 17 ±1.2 when observe more than once during follow-up. At 2 years, geographic atrophy developed in a lower percentage of eyes with VMT or VMA at baseline (11.7%) than with neither condition (22.5%, p=0.005). Conclusions VMT and VMA were infrequent in eyes in the CATT. At baseline and follow-up, VMT or VMA were not associated with VA. Eyes with VMT or VMA treated PRN required on average 2 more injections over 2 years.

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“…10 The risk of PVD increases with age but high myopia can lead to an earlier onset of vitreous liquefaction. [10][11][12] Information on the prevalence of PVD in myopia is limited; however, prevalence was reported to be 12.5 per cent in a group of young adults with high myopia and was substantially high at 60.7 per cent in eyes with longer axial lengths, that is, axial length > 30 mm. 13 PVD can be visualised with the help of optical coherence tomography (OCT).…”

Section: Posterior Vitreous Detachmentmentioning

confidence: 99%

Posterior segment conditions associated with myopia and high myopia

Jagadeesh

Philip

Fedtke

et al. 2020

Clinical and Experimental Optometry

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Myopia, and especially high myopia, is associated with a number of posterior segment changes that are considered to be mostly a consequence of the increased axial elongation. This can result in mechanical strain, attendant vascular changes, stretching and thinning of tissues, and atrophy/deformation of tissues in later or more advanced stages. Such myopiarelated changes are observed as changes and/or abnormalities in the vitreous, choroid, retina and peripheral retina, sclera and/or optic disc. Although many of these changes are benign, at times they may be associated with significant vision impairment that either requires active intervention or may suggest future progression of the disease. This review systematically addresses the posterior segment conditions seen in myopic eyes, describes the features associated with the condition and details management pathways.

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Prevalence and risk factors of posterior vitreous detachment in a Chinese adult population: the Handan eye study

Cited by 19 publications

References 25 publications

Characteristics and pathologies of the vitreo‐macular interface—results from the Gutenberg Health Study

Characteristics and pathologies of the vitreo‐macular interface—results from the Gutenberg Health Study

Influence of the Vitreomacular Interface on Treatment Outcomes in the Comparison of Age-Related Macular Degeneration Treatments Trials

Posterior segment conditions associated with myopia and high myopia

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