Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study

Wang, Chen; Xu, Jun‐Fa; Yang, Lan; Xu, Yu; Zhang, Xiangyan; Bai, Chunxue; Kang, Jian; Ran, Pixin; Shen, Huahao; Wen, Fuqiang; Huang, Kewu; Yao, Wan-zhen; Sun, Tieying; Shan, Guangliang; Yang, Ting; Lin, Yingxiang; Wu, Sinan; Zhu, Jianguo; Wang, Ruiying; Shi, Zhihong; Zhao, Jianping; Ye, Xianwei; Song, Yuanlin; Wang, Qiuyue; Zhou, Yumin; Ding, Liren; Chen, Yahong; Guo, Yanfei; Xiao, Fei; Lü, Yong; Peng, Xiaoxia; Zhang, Biao; Xiao, Dingquan; Chen, Chung-Shiuan; Wang, Zuomin; Zhang, Hong; Bu, Xiaoning; Zhang, Xiaolei; An, Li; Zhang, Shu; Cao, Zhixin; Zhan, Qingyuan; Yang, Yuanhua; Cao, Bin; Dai, Huaping; Liang, Lirong; He, Jiang

doi:10.1016/s0140-6736(18)30841-9

Cited by 1,136 publications

(1,108 citation statements)

References 33 publications

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“…Cigarette smoke is implicated as the primary cause of COPD. However, factors like exposure to indoor pollution from biomass fuels and outdoor air pollution including occupational dusts particularly in developing countries also seem to contribute to disease progression (Barnes et al, 2015;Maji, Dikshit, Arora, & Deshpande, 2018;Vogelmeier et al, 2017;Wang et al, 2018). Sohal et al (2010) reported on fragmentation of the reticular basement membrane in large airways from endobronchial biopsies of smokers, and the findings positively correlated with the subjects' smoking history.…”

Section: Potential Role Of Emt In Copdmentioning

confidence: 99%

“…As one of the best known second messengers, cAMP transmits the information carried by hormones, neurotransmitters, and other extracellular signals into the intracellular environment (Berthet et al, 1957;Musheshe et al, 2018). As one of the main bronchodilator therapies, β 2 -adrenoceptor agonists augment the anti-inflammatory effects of corticosteroids in obstructive lung diseases (Barnes et al, 2015;Maji et al, 2018;Vogelmeier et al, 2017;Wang et al, 2018). Even though it has been shown that the β 2 -adrenoceptor agonists inhibited cytokine release in vitro (Bosmann et al, 2012;Hallsworth, Twort, Lee, & Hirst, 2001;Poppinga et al, 2015), evidence for their anti-inflammatory properties in vivo is still lacking (Giembycz & Maurice, 2014;Giembycz & Newton, 2006).…”

Section: Outlook and Future Perspectivesmentioning

confidence: 99%

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Function of cAMP scaffolds in obstructive lung disease: Focus on epithelial‐to‐mesenchymal transition and oxidative stress

Zuo

Cattani‐Cavalieri

Musheshe

et al. 2019

British J Pharmacology

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Over the past decades, research has defined cAMP as one of the central cellular nodes in sensing and integrating multiple pathways and as a pivotal role player in lung pathophysiology. Obstructive lung disorders, such as chronic obstructive pulmonary disease (COPD), are characterized by a persistent and progressive airflow limitation and by oxidative stress from endogenous and exogenous insults. The extent of airflow obstruction depends on the relative deposition of different constituents of the extracellular matrix, a process related to epithelial‐to‐mesenchymal transition, and which subsequently results in airway fibrosis. Oxidative stress from endogenous and also from exogenous sources causes a profound worsening of COPD. Here we describe how cAMP scaffolds and their different signalosomes in different subcellular compartments may contribute to COPD. Future research will require translational studies to alleviate disease symptoms by pharmacologically targeting the cAMP scaffolds. Linked Articles This article is part of a themed section on Adrenoceptors—New Roles for Old Players. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.14/issuetoc

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Section: Potential Role Of Emt In Copdmentioning

confidence: 99%

Section: Outlook and Future Perspectivesmentioning

confidence: 99%

Function of cAMP scaffolds in obstructive lung disease: Focus on epithelial‐to‐mesenchymal transition and oxidative stress

Zuo

Cattani‐Cavalieri

Musheshe

et al. 2019

British J Pharmacology

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“…For example, the overall prevalence of COPD in the Chinese adult population is 8.6%. Smoking exposure of ≥20 pack-years, exposure to annual mean particulate matter with a diameter <2.5 μm of 50–74 μg⋅m −3 or ≥75 μg⋅m −3 , a body mass index (BMI) <18.5 kg⋅m −2 , childhood chronic cough, parental history of respiratory diseases, and low education are major risk factors [38]. …”

Section: Environmental Protectionmentioning

confidence: 99%

“…Emerging evidence indicates that nutrition can influence development and progression of obstructive respiratory diseases such as COPD and asthma [64]. In a population study, below the range of 22.5–25 kg⋅m −2 BMI correlated inversely with overall mortality, mainly because of strong inverse correlation with respiratory diseases and cancer [38, 65]. …”

Section: Nutritionmentioning

confidence: 99%

Lifestyle interventions in prevention and comprehensive management of COPD

Ambrosino

Bertella

2018

Breathe

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Chronic respiratory diseases are among the four major human chronic diseases. Tobacco smoke as well as environmental pollutants, infections, physical activity and nutritional status play a role in the prevalence, development and/or progression of chronic obstructive pulmonary disease (COPD).Changes in lifestyle are possible and may be beneficial in prevention and comprehensive management of COPD. Population-level interventions aimed at early diagnosis, promotion of vaccinations and prevention of infections, and reductions in smoking, environmental pollutants, physical inactivity, obesity and malnutrition may increase the number of life-years lived in good health.Educational aimsTo improve awareness of the influence of lifestyle on natural history of COPD.To describe the effects of some interventions to modify lifestyle in prevention and management.To provide information on the main clinical results.To define recommendations and limitations.

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“…The results showed that exposure to a high level of PM 2.5 (annual mean concentration ≥50 μg/m 3 ) was one risk factor for COPD 32. The results showed that exposure to a high level of PM 2.5 (annual mean concentration ≥50 μg/m 3 ) was one risk factor for COPD 32.…”

mentioning

confidence: 94%

Different health effects of indoor‐ and outdoor‐originated PM _2.5 on cardiopulmonary function in COPD patients and healthy elderly adults

Chi

Chen

et al. 2018

Indoor Air

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Numerous research has explored the associations of outdoor or indoor fine particulate matter (PM2.5) and health effects; however, few studies compared the effects of indoor PM2.5 originated from outdoor (PM2.5,os) and indoor sources (PM2.5,is). To assess the associations of PM2.5,os and PM2.5,is with cardiopulmonary function in patients with chronic obstructive pulmonary disease (COPD) and healthy elderly adults, blood pressure (BP) and pulmonary function were repeatedly examined in 43 COPD patients and their 32 healthy spouses in Beijing, China. Iron was used as tracer element to separate PM2.5,os and PM2.5,is. Mixed‐effects models were applied to assess the associations of PM2.5,os or PM2.5,is and health effects after controlling for potential confounders. There was a reduction in forced expiratory volume in first second (FEV1) in COPD patients associated with PM2.5,is during the heating season. PM2.5,os was positively associated with diastolic BP (DBP) in healthy elderly adults during the heating season. There was a reduction in peak expiratory flow (PEF) in healthy elderly adults associated with PM2.5,os during the non‐heating season. Exposure to indoor‐ and outdoor‐originated PM2.5 had different health effects on cardiopulmonary function in different populations. The results provide supporting evidence for improving indoor air quality to promote public health among susceptible population.

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Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study

Cited by 1,136 publications

References 33 publications

Function of cAMP scaffolds in obstructive lung disease: Focus on epithelial‐to‐mesenchymal transition and oxidative stress

Function of cAMP scaffolds in obstructive lung disease: Focus on epithelial‐to‐mesenchymal transition and oxidative stress

Lifestyle interventions in prevention and comprehensive management of COPD

Different health effects of indoor‐ and outdoor‐originated PM _2.5 on cardiopulmonary function in COPD patients and healthy elderly adults

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Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study

Cited by 1,136 publications

References 33 publications

Function of cAMP scaffolds in obstructive lung disease: Focus on epithelial‐to‐mesenchymal transition and oxidative stress

Function of cAMP scaffolds in obstructive lung disease: Focus on epithelial‐to‐mesenchymal transition and oxidative stress

Lifestyle interventions in prevention and comprehensive management of COPD

Different health effects of indoor‐ and outdoor‐originated PM 2.5 on cardiopulmonary function in COPD patients and healthy elderly adults

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Product

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Different health effects of indoor‐ and outdoor‐originated PM _2.5 on cardiopulmonary function in COPD patients and healthy elderly adults