Prevalence and seasonal pattern of enteric viruses among hospitalized children with acute gastroenteritis in Samawah, Iraq

Thwiny, Hazim T.; Alsalih, Nawar Jasim; Saeed, Zeayd Fadhil; Al-Yasari, Ali Mosa Rashid; Al-Saadawe, Moyed Abd AlHussein; Alsaadawi, Mohenned A.

doi:10.25122/jml-2021-0158

Cited by 8 publications

(3 citation statements)

References 49 publications

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“…The peak incidence rate was noted in 29.48% of patients during autumn, 19.28% during the winter, and 08.91% during spring. The lowest incidence rate, 7.38%, was observed during the summer season, and our results are in consensus, as reported by other studies [57]. Likewise, we also observed a significant monthly variation of adenovirus infections; a high frequency was noted during September 40.74%, January 33.33%, October 26.08%, and November 21.42%.…”

Section: Discussionsupporting

confidence: 92%

Epidemiology of Human Adenovirus in Pakistani Children Hospitalized with Community-Acquired Gastroenteritis under the Age of Five Years

Khan

Shamsullah

Shahidullah

et al. 2022

IJERPH

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Acute gastroenteritis is the major cause of morbidity and mortality among infants and children around the globe. Along with other enteropathogens, human adenovirus (HadV) is a major etiological agent associated with diarrhea in young children. However, information about the epidemiology of Adenoviruses in Pakistan is limited or has not been reported. A total of 1082 stool samples were collected from patients with acute gastroenteritis under the age of five years with symptoms of diarrhea, vomiting, nausea, and abdominal cramps who visited Benazir Bhutto Hospital Rawalpindi and Children’s hospital in Lahore of Punjab Province in Pakistan. Of this, 384 cases with no blood in their stool, negative for Rotavirus, and under the age of five years were recruited in this study. Human Adenoviruses were isolated in the human epithelial HEp-2 cell line. Furthermore, adenovirus antigen detection was carried out by an enzyme-linked immunosorbent assay (ELISA), and then all positive and negative samples were confirmed by nested PCR. After inoculating a clear stool supernatant on HEp-2 cell lines, we observed a positive cytopathic effect in 65 (16%) cases. Using an enzyme-linked immunosorbent assay, HAdV antigens were detected in 54 (14.06%) of the clear supernatant from gastroenteritis cases. However, HAdV hexon coding regions were amplified in 57 (14.80%) fecal samples, mainly from patients ≤24 months of age. The findings of this study suggest that adenovirus circulates significantly in the children population under the age of five years and may be the potential etiological factor of acute gastroenteritis in the mentioned cities. This study provides baseline data about the possible role of adenovirus in causing viral diarrhea in children. Further large-scale epidemiological surveys are recommended to better understand disease burden, etiological agents, and its clinical impact across the country.

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Section: Discussionsupporting

confidence: 92%

Epidemiology of Human Adenovirus in Pakistani Children Hospitalized with Community-Acquired Gastroenteritis under the Age of Five Years

Khan

Shamsullah

Shahidullah

et al. 2022

IJERPH

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“…Also, Thwiny et al. in Iraq described that the prevalence of rotaviruses, adenoviruses, and astroviruses was higher in the cold seasons of the year [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the detection of diarrhoea-associated RNA viruses in immunocompromised children in Iran

Yasaie,

Mousavi Nasab,

Shams

et al. 2024

Infection Prevention in Practice

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“…[3] In studies conducted in different countries, the prevalence of rotavirus was reported to vary from 9.7% to 35.9% and the prevalence of adenovirus from 2.5% to 17.1%. [3,[10][11][12][13][14][15] In studies conducted in different regions in Türkiye, rotavirus and adenovirus frequency rates were reported to vary from 6.7% to 20.2% and from 1.3% to 17.6% respectively. [4,[16][17][18][19][20] The difference in results of these studies may be due to both regional, climatic and socio-economic factors, and diagnostic methodology.…”

Section: Discussionmentioning

confidence: 99%

Frequency and seasonal distribution of rotavirus and adenovirus in patients with acute gastroenteritis

Kırca

Demirel²

2023

Journal of Contemporary Medicine

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Aims The aim of this study was to retrospectively determine the frequency of rotavirus and adenovirus and the distribution of these pathogens by age groups, gender and season in patients admitted to our hospital with gastroenteritis symptoms. Materials and Methods A total of 32755 stool samples collected from patients with gastroenteritis symptoms in the Medical Microbiology Clinic of the Hospital between January 1 and December 31, 2022 were evaluated retrospectively for rotavirus and adenovirus antigens. Rotavirus and adenovirus antigens were analyzed with the Rapid Cassette Test (Microcult, Biotech) kit. In addition, the distribution of pathogens by age groups, gender and season were examined. Statistical analysis was performed using Jamovi® version 2.3.21. Results Antigen test was positive in 9.9% of 32755 stool samples evaluated in our study. Rotavirus was detected in 8.4% and adenovirus in 1.5% of antigen positive samples. Both rotavirus and adenovirus antigen positivity were found to be statistically significantly higher in 0-1 and 2-3 age groups compared to other age groups (p

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Prevalence and seasonal pattern of enteric viruses among hospitalized children with acute gastroenteritis in Samawah, Iraq

Cited by 8 publications

References 49 publications

Epidemiology of Human Adenovirus in Pakistani Children Hospitalized with Community-Acquired Gastroenteritis under the Age of Five Years

Epidemiology of Human Adenovirus in Pakistani Children Hospitalized with Community-Acquired Gastroenteritis under the Age of Five Years

Evaluation of the detection of diarrhoea-associated RNA viruses in immunocompromised children in Iran

Frequency and seasonal distribution of rotavirus and adenovirus in patients with acute gastroenteritis

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