Prevalence and Severity of Food Allergies Among US Adults

Gupta, Ruchi S.; Warren, Christopher; Smith, Bridget; Jiang, Jialing; Blumenstock, Jesse; Davis, Matthew M.; Schleimer, Robert P.; Nadeau, Kari

doi:10.1001/jamanetworkopen.2018.5630

Cited by 757 publications

(575 citation statements)

References 40 publications

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“…However, 67.7% of symptomatic 6 year olds took diagnostic tests. Over a 26 million adults (10.8%) in the US have had at least one severe food allergic reaction [49], the occurrence of symptoms of food allergy in infancy and childhood, therefore, may provide valuable information on onset of food allergies.…”

Section: Discussionmentioning

confidence: 99%

The association of infant feeding patterns with food allergy symptoms and food allergy in early childhood

et al. 2019

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Background: The role of infant feeding for food allergy in children is unclear and studies have not addressed simultaneous exposures to different foods. The goal of this study was to analyze existing data on feeding practices that represent realistic exposure and assess the risk of food allergy symptoms and food allergy in children. Methods: The Infant Feeding Practices Study II conducted by the CDC and US-FDA enrolled pregnant women and collected infant feeding information using nine repeated surveys. Participants were re-contacted after 6 years. Food allergy data were collected at 4, 9, 12, and 72 months. In total, 1387 participants had complete infant feeding pattern data for 6 months and information on food allergy symptoms and doctors' diagnosed food allergy. Feeding patterns constituted six groups: 3-months of feeding at breast followed by mixed feeding, 3-months of breast milk and bottled milk followed by mixed feeding, 1-month of feeding at breast followed by mixed feeding, 6-months of mixed feeding i.e., concurrent feeding of breast milk, bottled milk and formula, 2-3 months of formula followed by formula and solid food, and formula and solid food since the first month. To estimate risks of food allergy, we used linear mixed models, controlling for potential confounders.Results: Of the 328 children with food allergy symptoms in infancy and at 6 years, 52 had persistent symptoms from infancy. Children exposed to mixed feeding had a higher risk of food allergy symptoms (Risk Ratio [RR] 1.54; 95% Confidence Interval [CI] 1.04, 2.29) compared to 3-months of feeding at breast adjusted for confounding. No statistically significant risk of infant feeding patterns was found for doctors' diagnosed food allergy. Paternal allergy posed a higher risk for food allergy symptoms (RR 1.36; 95% CI 1.01, 1.83). Prenatal maternal smoking increased the risk for doctors' diagnosed food allergy (RR 2.97; 95% CI 1.53, 5.79).Conclusions: Analysis of this prospective birth cohort suggest that introduction of multiple feeding source may lead to food allergy symptoms. Future efforts are needed to determine acceptable approaches to improve the ascertainment of food allergy in children and the role of infant feeding.

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Section: Discussionmentioning

confidence: 99%

The association of infant feeding patterns with food allergy symptoms and food allergy in early childhood

et al. 2019

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“…Comparison of amino acid sequence identities of (1)(2)(3)(4)(5) contigs from five shrimp species that matched with Troponin I (TNI) allergen and (6) known crayfish TNI allergen. The sequence identities were calculated using multiple sequence alignment in Clustal Omega (EMBL-EBI).…”

Section: Authors' Contributionsmentioning

confidence: 99%

“…Food allergy affects up to 10% of children and 10% of adults, and the prevalence is projected to be on the rise [1,2]. Food allergy is caused through ingestion of food that contains allergenic proteins that triggers adverse reactions in sensitised individuals [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Shellfish allergy is often lifelong, similar to peanut allergy, affects about 2% of the global population and appears to be highly prevalent in the Asia-Pacific region and other countries where seafood consumption is high [8][9][10][11]. A recent epidemiology study from Vietnam revealed that the prevalence of shellfish allergy is as high as 4.2% [11], while up to 3% of adults in the USA are sensitised to shellfish [1].…”

Section: Introductionmentioning

confidence: 99%

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Novel allergen discovery through comprehensivede novotranscriptomic analyses of 5 shrimp species

Karnaneedi

Huerlimann

Johnston

et al. 2020

Preprint

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Shellfish allergy affects up to 2% of the world's population and persists for life in most patients. The diagnosis of a shellfish allergy, in particular shrimp, is however often challenging due to the similarity of allergenic proteins in other invertebrates. Despite the clinical importance, the complete allergen repertoire of allergy-causing shrimps remains unclear. Here we mine the complete transcriptome of five frequently consumed shrimp species to identify and compare allergens with all known allergen sources. The transcriptomes were assembled de novo from raw RNA-Seq data of the whiteleg shrimp (Litopenaeus vannamei), black tiger shrimp (Penaeus monodon), banana shrimp (Fenneropenaeus merguiensis), king shrimp (Melicertus latisulcatus), and endeavour shrimp (Metapenaeus endeavouri). Trinity was used to assemble the transcriptome, and Transrate and BUSCO applied to verify the assembly. Blast search with the two major allergen databases, WHO/IUIS Allergen Nomenclature and AllergenOnline, successfully identified all seven known crustacean allergens. Salmon was utilised to measure their relative abundance, demonstrating sarcoplasmic calcium-binding protein, arginine kinase and myosin light chain as highly abundant allergens. In addition, the analyses revealed up to 40 unreported allergens in different shrimp species, including heat shock protein (HSP), alpha-tubulin, chymotrypsin,cyclophilin, beta-enolase, aldolase A, and glyceraldehyde-3-phosphate dehydrogenase (G3PD). Multiple sequence alignment, conducted in Jalview 2.1 with Clustal Omega, demonstrated high homology with allergens from other invertebrates including mites and cockroaches. This first transcriptomic analyses of allergens in a major food source provides a valuable genomic resource for investigating shellfish allergens, comparing invertebrate allergens and developing improved diagnostics and novel immunotherapeutics for food allergy. EJ and AL conceptualized the research objectives. SK, RH, EJ, RN, AT, and AL designed the research methods. RH, NW, and DJ provided the shrimp samples, conducted the RNA extraction and funded the RNA sequencing. SK and RH carried out the de novo transcriptome assembly, transcriptome quality check, BLAST search and relative abundance estimation. SK and RN constructed the allergen reference database and the molecular phylogenetic tree of known shellfish allergens. SK, RN, EJ, TR, AT, SDK, and AL determined the relevant allergens identified within the shrimp transcriptomes and the downstream analyses of these potential allergens. SK, RN, TR, RH, and AL designed the figures and tables. SK and AL wrote the first draft. All authors contributed to manuscript editing and revision.

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“…Allergic diseases, including food allergy (FA) and asthma, exert significant morbidity worldwide, with FA affecting up to 8% of children and 4-10% of adults in the US alone [1][2][3][4]. Yet, the availability of accurate biomarkers and effective treatments lags behind the ongoing FA epidemic, leaving providers with imperfect diagnostic tools and patients with food avoidance as their main treatment option.…”

Section: Introductionmentioning

confidence: 99%

Untargeted Metabolomic Profiling Identifies Disease-specific Profiles in Food Allergy

Crestani

Harb

Charbonnier

et al. 2019

Preprint

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Background. Food allergy (FA) affects an increasing proportion of children for reasons that remain obscure. Identification of pathogenic mechanisms involved in FA using untargeted metabolomic approaches may provide much needed diagnostic and prognostic disease biomarkers and improved treatment options.Methods. Mass spectrometry-based untargeted metabolomic profiling was performed on serum samples of children with either FA alone, asthma alone or both FA and asthma as well as healthy pediatric controls.Results. FA subjects exhibited a disease-specific metabolomic signature as compared to both control subjects and asthmatics. In particular, FA was uniquely associated with a marked decrease in sphingolipids, as well as a number of other lipid metabolites, in the face of normal frequencies of circulating natural killer T (NKT) cells. Specific comparison of FA and asthmatic subjects revealed differences in the microbiota-sensitive aromatic amino acid and secondary bile acid metabolism. Children with both FA and asthma exhibited a metabolomic profile that aligned with that of FA alone but not asthma. Among children with FA, distinct profiles were associated with history of severe reactions and presence of multiple FA. Conclusions.Children with FA display a disease-specific metabolomic profile that is informative of disease mechanisms and severity, and which dominates in the presence of asthma. Lower levels of sphingolipids and ceramides and other metabolomic alterations observed in FA children may reflect the interplay between an altered microbiota and immune cell subsets in the gut.

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Prevalence and Severity of Food Allergies Among US Adults

Abstract: This survey study provides nationally representative estimates of the distribution, severity, and factors associated with adult food allergy in the United States.

Cited by 757 publications

References 40 publications

The association of infant feeding patterns with food allergy symptoms and food allergy in early childhood

The association of infant feeding patterns with food allergy symptoms and food allergy in early childhood

Novel allergen discovery through comprehensivede novotranscriptomic analyses of 5 shrimp species

Untargeted Metabolomic Profiling Identifies Disease-specific Profiles in Food Allergy

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