Prevalence and Treatment Management of Oropharyngeal Candidiasis in Cancer Patients: Results of the French Candidoscope Study

Gligorov, J.; Bastit, Laurent; Gervais, H.; Henni, M.; Kahila, W.; Lepille, D.; Luporsi, É.; Sasso, Giuseppe; Varette, C.; Azria, D.

doi:10.1016/j.ijrobp.2010.02.006

Cited by 33 publications

(32 citation statements)

References 28 publications

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“…On the contrary, the oropharynx has been demonstrated to be more resistant to C. albicans colonization than the lower GI tract and vagina following antibiotic depletion of resident bacteria (40). Moreover, reports indicating an emergence of oral Candida infections after antibiotic treatment are rare and commonly associated with pharmacologically in- duced immunosuppression (25). The main determinant of oropharyngeal candidiasis seems to be the lack of a protective immune response, as evidenced by increased oral candidiasis in asthmatic patients using locally immunosuppressive corticosteroid inhalers, or during the early stages of AIDS, situations in which oral bacterial load is thought to remain for the most part unaltered (22,24).…”

Section: Discussionmentioning

confidence: 99%

Synergistic Interaction between Candida albicans and Commensal Oral Streptococci in a Novel In Vitro Mucosal Model

et al. 2012

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Candida albicans is a commensal colonizer of the gastrointestinal tract of humans, where it coexists with highly diverse bacterial communities. It is not clear whether this interaction limits or promotes the potential of C. albicans to become an opportunistic pathogen. Here we investigate the interaction between C. albicans and three species of streptococci from the viridans group, which are ubiquitous and abundant oral commensal bacteria. The ability of C. albicans to form biofilms with Streptococcus oralis, Streptococcus sanguinis, or Streptococcus gordonii was investigated using flow cell devices that allow abiotic biofilm formation under salivary flow. In addition, we designed a novel flow cell system that allows mucosal biofilm formation under conditions that mimic the environment in the oral and esophageal mucosae. It was observed that C. albicans and streptococci formed a synergistic partnership where C. albicans promoted the ability of streptococci to form biofilms on abiotic surfaces or on the surface of an oral mucosa analogue. The increased ability of streptococci to form biofilms in the presence of C. albicans could not be explained by a growth-stimulatory effect since the streptococci were unaffected in their growth in planktonic coculture with C. albicans. Conversely, the presence of streptococci increased the ability of C. albicans to invade organotypic models of the oral and esophageal mucosae under conditions of salivary flow. Moreover, characterization of mucosal invasion by the biofilm microorganisms suggested that the esophageal mucosa is more permissive to invasion than the oral mucosa. In summary, C. albicans and commensal oral streptococci display a synergistic interaction with implications for the pathogenic potential of C. albicans in the upper gastrointestinal tract.

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Section: Discussionmentioning

confidence: 99%

Synergistic Interaction between Candida albicans and Commensal Oral Streptococci in a Novel In Vitro Mucosal Model

et al. 2012

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“…Yeast carriage rates of 66% to 86% with OPC rates of 10% to 40% have ben reported. [1][2][3][4][5][6] Candida albicans is the main yeast of the digestive tract and genital area followed by C. glabrata, C. parapsilosis, and C. tropicalis. [7][8][9] OPC has primarily been associated with C. albicans, but recent studies have documented the shift to nonalbicans species such as C. dubliniensis and C. glabrata.…”

Section: Introductionmentioning

confidence: 99%

Oropharyngeal Candidiasis in Palliative Care Patients in Denmark

Astvad

Johansen

Høiby

et al. 2015

Journal of Palliative Medicine

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“…Dans cette étude, il est mis en évidence que parmi les 195 patients présentant une COP, sur les 2 027 patients répertoriés dans le registre, 25 % Tableau 1. Facteurs favorisants de la COP [15,19] avaient un cancer du sein ; cela est dû à la prévalence élevée du cancer du sein [4].…”

Section: Fréquence Globale Et Selon Les Localisationsunclassified

“…La COP est une pathologie fré-quente en cancérologie [4], mais très probablement sous-estimée. Si elle engage rarement le pronostic vital, excepté lorsqu'elle est associée à une candidose systémique, elle modifie fortement la qualité de vie des patients traités en entraînant notamment un cortège de symptômes pouvant altérer le goût, la sensibilité et retentir sur l'alimentation.…”

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